在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PPOX Antibody

  • 中文名稱:
    PPOX兔多克隆抗體
  • 貨號:
    CSB-PA121495
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA121495(PPOX Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA121495(PPOX Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, 293T cells, Primary antibody: CSB-PA121495(PPOX Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PPOX
  • 別名:
    MGC8485 antibody; PPO antibody; PPOX antibody; PPOX_HUMAN antibody; Protoporphyrinogen oxidase antibody; V290M antibody; Variegate porphyria antibody; VP antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human PPOX
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
  • 基因功能參考文獻:
    1. the regulation of PPOX gene expression can also occur through a post-transcriptional modulation of the amount of gene product and this modulation can be mediated by 5' untranslated exon 1. PMID: 27667166
    2. GAPDH and protoporphyrinogen oxidase were shown to have higher expression in faster growing cell lines and primary tumors. Pharmacologic inhibition of GAPDH or PPOX reduced the growth of colon cancer cells in vitro PMID: 25944804
    3. Variegate porphyria is the result of decreased protoporphyrinogen oxidase activity. Diet supplementation with vitamins E and C restores PPOX gene expression in lymphocytes of variegate porphyria patients. PMID: 23601071
    4. in the hepatic cancer tissue of two acute porphyria patients, somatic second-hit mutations result in nearly complete inactivation of PPOX and HMBS PMID: 25445397
    5. The c.851G>T and the c.1013C>G of PPOX gene were found in two and four unrelated families respectively. 1 experienced only photosensitivity, 1 only neurological symptoms and the 2 both clinical manifestations. PMID: 19656455
    6. The mutation 1082-1083insC(1 base pair insertion at position 1082) in exon 10 of the PPOX gene was prevalent in the Swiss population. PMID: 19656457
    7. findings emphasize the usefulness of MLPA analysis as a complement to PPOX gene sequencing analysis for comprehensive genetic diagnostics in patients with variegate prophyria PMID: 23324528
    8. VP-causing mutation affect the catalytic activity of hPPO by affecting the ability of hPPO to sample the privileged conformations PMID: 23467411
    9. sequenced 27 members of a family with variegate porphyria with a T>A transversion at the intron 6 consensus splicing site in 8 patients and 4 SNPs: c.-414A>C; IVS2+121G>C; c.1188G>A and IVS12+34C>T PMID: 19229653
    10. data deliver further confirmation that the South African and Dutch variegate porphyria families carrying mutation p.R59W shared a common ancestor. PMID: 21910705
    11. Forty-seven variegate porphyria-causing mutations were purified by chromatography and kinetically characterized in vitro. PMID: 21048046
    12. Two previously undescribed mutations were identified: PPOX1423-1426-delATCT and PPOX2272insG. PMID: 12017191
    13. This enzyme in its regular and mutagenized forms is targeted to mitochondria when transfected. PMID: 12556518
    14. Information required for targeting to the mitochondria is contained within the first 250 amino acid residues of human PPOX. PMID: 14535846
    15. Modulation of penetrance by the wild-type allele in dominantly inherited erythrohepatic and acute hepatic porphyrias was studied using PPOX. PMID: 14669009
    16. Protoporphyrinogen oxidase targeting mechanism to the mitochondrion. PMID: 16621625
    17. Mutation in protoporphyrinogen oxidase is associated with variegate porphyria PMID: 16947091
    18. GATA-1 binding sites in exon 1 constitute key regulatory elements in differential expression of PPOX in erythroid and non-erythroid cells. PMID: 18191920

    顯示更多

    收起更多

  • 相關疾病:
    Variegate porphyria (VP)
  • 亞細胞定位:
    Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
  • 蛋白家族:
    Protoporphyrinogen oxidase family
  • 組織特異性:
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 9280

    OMIM: 176200

    KEGG: hsa:5498

    STRING: 9606.ENSP00000343943

    UniGene: Hs.517373



主站蜘蛛池模板: 国产成人一区二区三区app| 国产一区二区内射最近更新| 亚洲精品久久久久久久蜜桃| 婷婷四房综合激情五月| 在线人人车操人人看视频| 欧美人与动牲交zooz男人| 亚洲a综合一区二区三区| 精品少妇无码一区二区三批 | 亚洲一区二区三区乱码在线欧洲 | 无码中文字幕av免费放dvd| 欧美xxxxx精品| 久激情内射婷内射蜜桃| 国产伦子系列沙发午睡| 狼友av永久网站免费观看孕交| 亚洲高清国产拍精品26u| 特黄三级又爽又粗又大| 免费又黄又硬又爽大片| 国产成人人人97超碰超爽8| 在线不卡日本v二区到六区| 动漫精品专区一区二区三区| 午夜无码国产理论在线| 久久精品蜜芽亚洲国产av| 成人性做爰aaa片免费看| 无套内谢少妇毛片aaaa片免费| 天下第一社区视频www日本| 亚洲欧美日韩一区二区| 久久精品国产精品亚洲| 久久久久欧美国产高潮| 国产l精品国产亚洲区| 男女18禁啪啪无遮挡激烈网站| 欧美成人精品三级网站| 女人张开腿让男人桶爽| 国产一区二区三区四区精华| 亚洲hdmi高清线| 性色av无码一区二区三区人妻| 少妇人妻精品一区二区| 国产制服丝袜亚洲高清| 中文精品久久久久鬼色| 久久99亚洲精品久久99果 | 国产男女猛烈无遮挡免费网站| 色天天天综合色天天|