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PPM1H Antibody, Biotin conjugated

  • 中文名稱:
    PPM1H兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA892345LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PPM1H Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PPM1H
  • 別名:
    PPM1H antibody; ARHCL1 antibody; KIAA1157 antibody; URCC2 antibody; Protein phosphatase 1H antibody; EC 3.1.3.16 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein phosphatase 1H protein (73-289AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation.
  • 基因功能參考文獻:
    1. PPM1H may be a new tumor-suppressor factor for pancreatic cancer and provides new insight into molecular targets for gene therapy of pancreatic cancer PMID: 27599670
    2. PPM1H acts as a gatekeeper to prevent excessive BMP signaling through dephosphorylation and subsequent nuclear exclusion of P-Smad1/5/8 proteins. PMID: 24732009
    3. Knockdown of the serine/threonine phosphatase PPM1H confers trastuzumab resistance via reduction in protein levels of the tumor suppressor p27. PMID: 22586611
    4. PPM1H, overexpressed in colon adenocarcinoma, is associated with CSE1L protein. PMID: 18059182
  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    PP2C family
  • 數據庫鏈接:

    HGNC: 18583

    OMIM: 616016

    KEGG: hsa:57460

    UniGene: Hs.435479



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