在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PPM1B Antibody

PPM1B Antibody

  • 中文名稱：
    PPM1B兔多克隆抗體
  • 貨號：
    CSB-PA018490GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    MGC21657 antibody; OTTHUMP00000158953 antibody; OTTHUMP00000158954 antibody; OTTHUMP00000158955 antibody; OTTHUMP00000202394 antibody; OTTHUMP00000202395 antibody; OTTHUMP00000202399 antibody; PP2C beta antibody; PP2C beta X antibody; PP2C-beta antibody; PP2CB antibody; PP2Cbeta antibody; PPC2BETAX antibody; PPM 1B antibody; Ppm1b antibody; PPM1B_HUMAN antibody; Protein phosphatase 1B (formerly 2C) magnesium dependent beta isoform antibody; Protein phosphatase 1B antibody; Protein phosphatase 1B magnesium dependent beta isoform antibody; Protein phosphatase 2C beta isoform antibody; Protein phosphatase 2C isoform beta antibody; Protein phosphatase 2C like protein antibody; Protein phosphatase, Mg2+/Mn2+ dependent, 1B antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PPM1B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
  • 基因功能參考文獻：
    1. Results indicate that protein phosphatase 1B (PPM1B) negatively regulates cancer cell motility and invasiveness through dephosphorylating Rho guanine nucleotide dissociation inhibitor 1 (RhoGDI1). PMID: 29307615
    2. PPM1B plays a negative role in the activation of the p38-RB1-E2F1 pathway and that targeting PPM1B could be useful in certain types of cancer by stimulating chemotherapy-induced cell death. PMID: 29654756
    3. This study has identified PPM1B and miR-186 as potential diagnostic markers in bladder cancer. Promotion of PPM1B and suppression of miR-186 may offer effective therapeutic strategies in the treatment of bladder cancer. PMID: 26494000
    4. PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing. PMID: 25631048
    5. Results identify PPM1B as a critical regulator of both p38 MAPK-dependent and independent senescence pathways during normal cellular aging process. PMID: 24674756
    6. Cadmium reversed PPM1A-induced cell cycle arrest and cadmium insensitive PPM1A mutant rescued cadmium induced cell death. PMID: 23903585
    7. Protein kinase A activates NF-kappaB-mediated transcription by destabilization of PP2Cbeta. PMID: 23756813
    8. PPM1B functions as a TBK1 phosphatase dephosphorylates TBK1 at serine 172 and terminates TBK1-mediated IRF3 activation and IFNbeta gene expression. PMID: 22750291
    9. Studies show that Ppm1b plays a multilayered role in regulating the availability and optimal activity of the EKLF protein in erythroid cells. PMID: 22393050
    10. results implicate a novel and important role for PP2Cbetal in regulating hPXR activity and CYP3A4 expression by inhibiting or desensitizing signaling pathways that negatively regulate the function of pregnane X receptor in liver cells PMID: 20538721
    11. PP2Cbeta down-regulates cytokine-induced NF-kappaB activation by altering IKK activity. PMID: 14585847
    12. Protein phosphatase 1B is mediated dephosphorylation and inactivation of I-kappa B kinase as well as the termination of the Tumor Necrosis Factor-alpha-induced NF-kappaappaB activation. PMID: 18930133

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Membrane; Lipid-anchor.
  • 蛋白家族：
    PP2C family
  • 組織特異性：
    Highly expressed in heart and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9276

    OMIM: 603770

    KEGG: hsa:5495

    STRING: 9606.ENSP00000282412

    UniGene: Hs.416769



主站蜘蛛池模板： 亚洲中文字幕无码久久精品1| 亚洲日韩中文字幕在线不卡最新 | 久久人人97超碰国产公开| 国产在线精品视频免费观看| 午夜精品久久久久久久爽 | 亚洲超清无码制服丝袜无广告| 无码中文av波多野结衣一区| 中文字幕av无码一区二区三区| 欧美3p两根一起进高清免费视频| 国内无遮挡18禁无码网站免费| 国产 日韩 中文字幕 制服| 性史性农村dvd毛片| 欧性猛交ⅹxxx乱大交| 久久精品成人免费国产片小草| 狠狠色丁香久久婷婷综合蜜芽五月 | 久久国产人妻一区二区| 好吊色欧美一区二区三区视频 | 东京无码熟妇人妻av在线网址| 成年轻人电影www无码| 国产美女午夜福利视频| 国产乱子伦60女人的皮视频| 国产a在亚洲线播放| 欧美亚洲综合成人a∨在线| 日产精品一卡2卡三卡4乱码| 欧美婷婷六月丁香综合色 | 色偷偷色噜噜狠狠网站久久 | 波多野结衣不打码视频| 无码人妻丰满熟妇精品区| 亚洲中文字幕久久精品蜜桃| 欧美野性肉体狂欢大派对| 日日躁夜夜躁狠狠躁超碰97| 亚洲综合av色婷婷五月蜜臀| 中文字幕av无码免费久久| 日韩毛片免费无码无毒视频观看| 国产特级毛片aaaaaa| 少妇性荡欲视频| 中文字幕人妻无码一夲道| 亚洲欧美日韩国产手机在线| 亚洲中文字幕无码中文| 国产福利一区二区三区在线视频| 躁躁躁日日躁|