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PPIE Antibody, FITC conjugated

  • 中文名稱:
    PPIE兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA890944LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PPIE Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PPIE
  • 別名:
    Ab1-210 antibody; Cyclophilin 33 antibody; Cyclophilin E antibody; Cyclophilin-33 antibody; CYP 33 antibody; CYP33 antibody; EC 5.2.1.8 antibody; Peptidyl prolyl cis trans isomerase E antibody; Peptidyl-prolyl cis-trans isomerase E antibody; Peptidylprolyl isomerase E (cyclophilin E) antibody; Peptidylprolyl isomerase E antibody; PPIase E antibody; PPIE antibody; PPIE_HUMAN antibody; Rotamase E antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Peptidyl-prolyl cis-trans isomerase E protein (86-141AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity.
  • 基因功能參考文獻:
    1. CypE is a host restriction factor that inhibits the functions of nucleoprotein, as well as viral replication and transcription, by impairing the formation of the viral ribonucleoprotein complex. PMID: 21887220
    2. binding of H3K4me3 to PHD3 domain of MLL and binding of the CYP33 RRM domain to PHD3 are mutually inhibitory, implying that PHD3 is a molecular switch for the transition between activation and repression of target genes PMID: 20677832
    3. PPIase domain of CyP33 regulates the conformation of MLL1 through proline isomerization within the PHD3-Bromo linker, thereby disrupting the PHD3-Bromo interface and facilitating binding of the MLL1-PHD3 domain to the CyP33-RRM domain. PMID: 20541251
    4. Data provide insight into the multiple functions of Cyp33 RRM and suggest a Cyp33-dependent mechanism for regulating the transcriptional activity of MLL. PMID: 20460131
    5. The results show that hCyP33 binds specifically to mRNA, namely poly(A)(+)RNA, and that binding stimulates the PPIase activity of hCyP33. PMID: 18258190

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  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Cyclophilin-type PPIase family, PPIase E subfamily
  • 組織特異性:
    Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 9258

    OMIM: 602435

    KEGG: hsa:10450

    UniGene: Hs.524690



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