在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. POU3F2 Antibody

POU3F2 Antibody

  • 中文名稱：
    POU3F2兔多克隆抗體
  • 貨號：
    CSB-PA018397GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    POU3F2
  • 別名：
    Brain 2 antibody; Brain specific homeobox/POU domain protein 2 antibody; Brain-2 antibody; Brain-specific homeobox/POU domain protein 2 antibody; BRN 2 antibody; Brn-2 antibody; BRN2 antibody; N Oct 3 antibody; N OCT 3 Gene antibody; N Oct3 antibody; Nervous system specific octamer binding transcription factor antibody; Nervous system-specific octamer-binding transcription factor N-Oct-3 antibody; OCT 7 antibody; Oct-7 antibody; OCT7 antibody; Octamer Binding Transcription Factor 7 antibody; Octamer-binding protein 7 antibody; Octamer-binding transcription factor 7 antibody; OTF 7 antibody; OTF-7 antibody; OTF7 antibody; PO3F2_HUMAN antibody; POU class 3 homeobox 2, antibody; POU domain class 3 transcription factor 2 antibody; POU domain, class 3, transcription factor 2 antibody; Pou3f2 antibody; POUF 3 antibody; POUF3 antibody; Protein Brn 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human POU3F2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes.
  • 基因功能參考文獻：
    1. Re4sults show that BRN2 is: directly transcriptionally repressed by AR, required for the expression of terminal neuroendocrine markers and aggressive growth of castration-resistant prostate cancer (CRPC), and is highly expressed in human neuroendocrine prostate cancer and metastatic CRPC with low circulating PSA. PMID: 27784708
    2. These findings not only shed light on the molecular mechanism of the anticancer properties of capsaicin, but also the transcription regulation of tNOX expression that may potentially explain how POU3F2 is associated with tumorigenesis. PMID: 27271588
    3. We show that POU3F2 lies downstreamof SIM1 and controls oxytocin expression in the hypothalamic neuroendocrine preoptic area. We show that this finding is consistent with the expression patterns of POU3F2 and related genes in the human brain. PMID: 26833329
    4. TTF1 expression in small-cell lung cancer is a cell lineage-specific phenomenon that involves the developing neural cell-specific homeoprotein BRN2. PMID: 23358112
    5. The present study investigated transcriptional regulation of CDH13 in melanoma. Found an inverse correlation between BRN2 and T-cadherin protein and transcript expression in melanoma. PMID: 23069940
    6. links BRN2 as an activator and MITF as a repressor of the NOTCH pathway in melanoma cells. Loss of the BRN2-MITF axis in antisense-ablated cell lines decreased the melanoma sphere-forming capability and cell adhesion PMID: 21358674
    7. a model for the apparent non-overlapping expression levels of BRN2 and MITF in melanoma, mediated by miR-211 expression. PMID: 21435193
    8. POU3F2 may regulate the properties of melanoma cells via autocrine KIT ligand signalling. PMID: 20337985
    9. The results suggest that the high levels of Brn-2 expression observed in melanomas link BRAF signaling to increased proliferation. PMID: 15024080
    10. Rb induces a proliferative arrest and regulates Brn-2 expression in retinoblastoma cells PMID: 17163992
    11. Brn-2 regulates invasiveness and directly represses Mitf expression. PMID: 18829533
    12. SOX9 and SOX10 but not BRN2 seem to be required for nestin expression in human melanoma. PMID: 18923447
    13. Expression and purification of full-length BRN2, a transcription factor involved in melanoma growth, are reported. PMID: 18996486

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    POU transcription factor family, Class-3 subfamily
  • 組織特異性：
    Expressed specifically in the neuroectodermal cell lineage.
  • 數據庫鏈接：

    HGNC: 9215

    OMIM: 600494

    KEGG: hsa:5454

    STRING: 9606.ENSP00000329170

    UniGene: Hs.182505



主站蜘蛛池模板： 精品视频国产狼友视频| 国产成人精品三上悠亚| 乱人伦xxxx国语对白| 亚洲精品无码成人片| 国产69精品久久久久乱码韩国| 手机真实国产乱子伦对白视频| 人人妻人人澡人人爽人人精品电影 | 特黄熟妇丰满人妻无码| 亚洲熟妇国产熟妇肥婆| 伊人久久大香线蕉av波多野结衣| 日日摸日日碰夜夜爽无码| 国产亚洲精品欧洲在线观看| 久久综合给合久久狠狠狠97色| …日韩人妻无码精品一专区| 亚洲a片国产av一区无码| 亚洲狠狠色丁香婷婷综合| 在线观看国产精品av| 国产精品久久无码一区| 真人抽搐一进一出gif| 精品国产一区二区三区av孞弋 | 国产裸拍裸体视频在线观看| 中文字幕av无码不卡| 国产美女a做受大片观看| 国产亚洲精品a片久久久| 国模小黎自慰gogo人体| 女人被狂躁c到高潮视频| 国产成人乱色伦区| 亚洲中文无码线在线观看| 国产一区二区三区小说| 自拍偷在线精品自拍偷99| 国产成人欧美日韩在线电影| av无码一区二区大桥未久| 人妻少妇中文字幕久久| 亚洲高清无在码在线电影不卡 | 中文字幕高清免费日韩视频在线| 欧美精品中文字幕亚洲专区| 动漫av纯肉无码av电影网| 韩国精品视频一区二区在线播放 | 国产在线精品一区二区| 欧美精品九九久久久久久久久| 日韩人妻无码一区二区三区俄罗斯|