在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. POU2F2 Antibody

POU2F2 Antibody

  • 中文名稱：
    POU2F2兔多克隆抗體
  • 貨號：
    CSB-PA280193
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA280193(POU2F2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human renal cancer tissue using CSB-PA280193(POU2F2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: CSB-PA280193(POU2F2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 hour
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    POU2F2
  • 別名：
    class 2 antibody; Lymphoid restricted immunoglobulin octamer binding protein antibody; Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2 antibody; NF A2 antibody; Oct 2 antibody; Oct-2 antibody; Octamer binding transcription factor 2 antibody; Octamer-binding protein 2 antibody; Octamer-binding transcription factor 2 antibody; OTF-2 antibody; OTF2 antibody; PO2F2_HUMAN antibody; POU domain antibody; POU domain class 2 transcription factor 2 antibody; POU2F2 antibody; transcription factor 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human POU2F2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates IL6 expression in B cells with POU2AF1. Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.; Activates the U2 small nuclear RNA (snRNA) promoter.
  • 基因功能參考文獻(xiàn)：
    1. Identification of novel prostate cancer drivers, ERF, CREB3L1, and POU2F2, using RegNetDriver, a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network. PMID: 28750683
    2. POU2F2 regulated ROBO1 transcription, thus functionally contributing to Gastric cancer metastasis. PMID: 26019213
    3. findings show that cellular factors OCT2 and HCF1 bind OriP in association with Epstein-Barr virus nuclear antigen 1 to maintain elevated histone H3K4me3 and transcriptional enhancer function PMID: 27009953
    4. B-cell specific transcription factor, Oct-2, inhibits the function of the viral immediate-early protein, BZLF1, and prevents lytic viral reactivation. Oct-2 potentiates establishment of EBV latency in B cells. PMID: 22346751
    5. Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma. PMID: 24435047
    6. Half of the cases displayed Oct-2 expression (15/30 cases) of systemic anaplastic large-cell lymphoma measured by tissue microarray immunohistochemistry. PMID: 22158496
    7. OCT-2 may act as a cell survival factor in acute myeloid leukemia by mediating expression of downstream targets, such as BCL-2. PMID: 20141429
    8. Gefitinib may exert an inhibitory effect on the intracellular accumulation of drugs transported by hOCT1 and hOCT2. PMID: 20363215
    9. The function of human Oct-2 in immunoglobulin(Ig)-secreting cells requires plasmacytoma-specific coativator OCA-B working synergistically to sustain the gene expression profile of the Ig-secreting cell. PMID: 14662861
    10. DNase I-hypersensitive site 4 (hs4) enhancer activity in mature Burkitt's lymphoma B cells is regulated by synergistic involvement of both Oct-2 and NF-kappa B family members; Oct-2 is required for hs4 enhancer activity. PMID: 14707079
    11. Alteration of the OCT2 locus does not correlate with its suppressed expression in Hodgkin lymphoma. PMID: 15796964
    12. Oct-2, therefore, acts as a cell survival factor in t(14;18) lymphoma cells by directly activating the antiapoptotic gene bcl-2. PMID: 16186795
    13. Oct-2, was studied in detail and found to be a bifunctional regulator: It can either repress or induce neuronal differentiation, depending on the particular isoform PMID: 19270158
    14. Data suggest that OCT2 and/or OCT3 might be involved in the initial component of histamine uptake, whereas the later component of histamine uptake is likely to be mediated by another, as yet undefined uptake system(s). PMID: 19271143
    15. Renal OCT2 expression is no important in the renal excretion of metformin PMID: 19536068

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    POU transcription factor family, Class-2 subfamily
  • 組織特異性：
    Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9213

    OMIM: 164176

    KEGG: hsa:5452

    STRING: 9606.ENSP00000431603

    UniGene: Hs.147381



主站蜘蛛池模板： 国産精品久久久久久久| 久久精品一区二区av999| 中文字幕日韩人妻在线视频| 亚洲精品中文字幕无码蜜桃| 美女黄18以下禁止观看| 国产精品无码av片在线观看播 | 无码任你躁久久久久久老妇| 欧美videos另类极品| 国产做a爰片久久毛片a片美国| 国产成人免费永久在线平台| 日本丰满少妇裸体自慰| 亚洲一线二线三线写真| 无遮挡午夜男女xx00动态| 小12箩利洗澡无码视频网站| 精品1卡二卡三卡四卡老狼| 亚洲乱码中文字幕在线| 欧美乱码伦视频免费| 国产剧情无码播放在线观看| 国产偷人爽久久久久久老妇app| 四虎国产成人永久精品免费| 久久精品国产精品国产一区| 亚洲国产成人久久精品99| 久久久久久a亚洲欧洲av冫| 国产精品欧美一区二区三区| 久久大蕉香蕉免费| 亚洲国产精品无码中文字2022| 国产精品免费精品自在线观看| 在线高清亚洲精品二区| 国产精品va在线观看h| 狠狠人妻久久久久久综合蜜桃| 51久久成人国产精品麻豆| 免费能直接看黄的视频| 亚洲欧洲精品成人久久曰影片| 精品久久久久久中文字幕| 国产精品成人片在线观看| 欧美阿v高清资源在线| 欧美丰满熟妇xxxx性大屁股| 国内高清久久久久久| 国产性夜夜春夜夜爽免费下载 | 丰满女人又爽又紧又丰满| 亚洲色大成网站www永久一区|