在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POU2F2 Antibody

  • 中文名稱:
    POU2F2兔多克隆抗體
  • 貨號:
    CSB-PA575296
  • 規格:
    ¥2024
  • 圖片:
    • Immunofluorescence analysis of COS7 cells, using OCT2 antibody.
    • Western blot analysis of extracts from COS7 cells, using OCT2 antibody.
    • Western blot analysis of extracts from JK cells (Lane 2), using OCT2 antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POU2F2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    POU2F2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from Human OCT2 antibody.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates IL6 expression in B cells with POU2AF1. Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR.; Activates the U2 small nuclear RNA (snRNA) promoter.
  • 基因功能參考文獻:
    1. Identification of novel prostate cancer drivers, ERF, CREB3L1, and POU2F2, using RegNetDriver, a framework for integration of genetic and epigenetic alterations with tissue-specific regulatory network. PMID: 28750683
    2. POU2F2 regulated ROBO1 transcription, thus functionally contributing to Gastric cancer metastasis. PMID: 26019213
    3. findings show that cellular factors OCT2 and HCF1 bind OriP in association with Epstein-Barr virus nuclear antigen 1 to maintain elevated histone H3K4me3 and transcriptional enhancer function PMID: 27009953
    4. B-cell specific transcription factor, Oct-2, inhibits the function of the viral immediate-early protein, BZLF1, and prevents lytic viral reactivation. Oct-2 potentiates establishment of EBV latency in B cells. PMID: 22346751
    5. Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma. PMID: 24435047
    6. Half of the cases displayed Oct-2 expression (15/30 cases) of systemic anaplastic large-cell lymphoma measured by tissue microarray immunohistochemistry. PMID: 22158496
    7. OCT-2 may act as a cell survival factor in acute myeloid leukemia by mediating expression of downstream targets, such as BCL-2. PMID: 20141429
    8. Gefitinib may exert an inhibitory effect on the intracellular accumulation of drugs transported by hOCT1 and hOCT2. PMID: 20363215
    9. The function of human Oct-2 in immunoglobulin(Ig)-secreting cells requires plasmacytoma-specific coativator OCA-B working synergistically to sustain the gene expression profile of the Ig-secreting cell. PMID: 14662861
    10. DNase I-hypersensitive site 4 (hs4) enhancer activity in mature Burkitt's lymphoma B cells is regulated by synergistic involvement of both Oct-2 and NF-kappa B family members; Oct-2 is required for hs4 enhancer activity. PMID: 14707079
    11. Alteration of the OCT2 locus does not correlate with its suppressed expression in Hodgkin lymphoma. PMID: 15796964
    12. Oct-2, therefore, acts as a cell survival factor in t(14;18) lymphoma cells by directly activating the antiapoptotic gene bcl-2. PMID: 16186795
    13. Oct-2, was studied in detail and found to be a bifunctional regulator: It can either repress or induce neuronal differentiation, depending on the particular isoform PMID: 19270158
    14. Data suggest that OCT2 and/or OCT3 might be involved in the initial component of histamine uptake, whereas the later component of histamine uptake is likely to be mediated by another, as yet undefined uptake system(s). PMID: 19271143
    15. Renal OCT2 expression is no important in the renal excretion of metformin PMID: 19536068

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    POU transcription factor family, Class-2 subfamily
  • 組織特異性:
    Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147.
  • 數據庫鏈接:

    HGNC: 9213

    OMIM: 164176

    KEGG: hsa:5452

    STRING: 9606.ENSP00000431603

    UniGene: Hs.147381



主站蜘蛛池模板: 亚洲精品久久午夜无码一区二区| 久久精品人妻无码一区二区三区| 久久国产成人精品国产成人亚洲| 黑人上司粗大拔不出来电影| 亚洲第一天堂无码专区| 玩弄少妇人妻中文字幕| 18禁男女爽爽爽午夜网站免费| 久久99国产只有精品| 亚洲国产成人久久一区久久| 国产精品毛多多水多| 国产av成人一区二区三区| 无修无码h里番在线播放网站| 成人a毛片视频免费看| 国产偷国产偷亚洲高清app| 四虎国产精品永久在线| 国产精品亚洲综合久久系列| 野花社区www视频最新资源| 99精品久久精品一区二区| 欧美精品18videosex性欧美| 久久精品网站免费观看| 麻花传媒mv国产免费观看视频 | 精品国产一区二区av麻豆不卡| 欧美老妇疯狂xxxxbbbb| 野花社区视频www官网| 欧美金妇欧美乱妇xxxx| 西西人体大胆瓣开下部毛茸茸 | 性生交大片免费看女人按摩| 国产精品亚洲综合一区在线观看| 亚洲乱码日产精品bd在线| 少妇被躁爽到高潮无码文| 国产成人精品白浆久久69| 伊人久久大香线蕉av综合| 久久精品亚洲中文字幕无码麻豆| 男男啪啪激烈高潮cc漫画免费| 在线亚洲视频网站www色| 国产成人精品999视频| 久久精品国产精品亚洲艾草网| 无遮挡aaaaa大片免费看| 亚洲国产日韩一区三区| 国产精品无码v在线观看| 免费无遮挡无码视频网站|