在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POU2AF1 Antibody

  • 中文名稱:
    POU2AF1兔多克隆抗體
  • 貨號:
    CSB-PA620973LA01HU
  • 規格:
    ¥440
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POU2AF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    POU2AF1
  • 別名:
    B cell Oct binding protein 1 antibody; B cell specific coactivator OBF 1 antibody; B cell specific coactivator OBF1 antibody; B-cell-specific coactivator OBF-1 antibody; BOB 1 antibody; BOB-1 antibody; OBF 1 antibody; OBF1 antibody; OBF1_HUMAN antibody; OCA B antibody; OCA-B antibody; OCAB antibody; OCT binding factor 1 antibody; OCT-binding factor 1 antibody; POU class 2 associating factor 1 antibody; POU domain class 2 associating factor 1 antibody; POU domain class 2-associating factor 1 antibody; Pou2af1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human POU domain class 2-associating factor 1 protein (1-256AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,POU2AF1 Antibody (CSB-PA620973LA01HU),的標記方式是Non-conjugated。對于POU2AF1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA620973LB01HU POU2AF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA620973LC01HU POU2AF1 Antibody, FITC conjugated
    Biotin CSB-PA620973LD01HU POU2AF1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator.
  • 基因功能參考文獻:
    1. The number of follicular B2 lymphocytes and expression of the B-cell-specific transcriptional coactivator OcaB increase with age in spleen and in intra-abdominal epididymal white adipose tissue (eWAT), concomitantly with higher circulating levels of IgG and impaired glucose homeostasis. PMID: 29496744
    2. These findings demonstrate for the first time that functional polymorphism in the 3'-UTR of POU2AF1 is associated with susceptibility, and that single-nucleotide polymorphisms interaction with hsa-miR-633 affects gene expression and increases the risk of lymphoma. PMID: 28345816
    3. Oct2 and Bob1 are very reliable in determining B cell lineage in the absence of expression of other pan-B cell markers PMID: 27319306
    4. these findings suggest a novel function of POU2AF1 as a potential regulator of host defense genes in the human airway epithelium. PMID: 26927796
    5. It has been identified as a new disease susceptibility gene among Japanese. Though different from Europeans, it is indicated that a B lymphocyte differentiation route shares a common disease developing process. [Review] PMID: 24005100
    6. Two significant susceptibility loci, TNFSF15 (rs4979462) and POU2AF1 (rs4938534) (combined odds ratio [OR] = 1.56, p = 2.84 x 10(-14) for rs4979462. PMID: 23000144
    7. genetic polymorphism is associated with common variable immunodeficiency PMID: 21905497
    8. Data show that Igh 3' enhancer-bound OCA-B and promoter-bound TFII-I mediate promoter-enhancer interactions, in both cis and trans, that are important for Igh transcription. PMID: 21549311
    9. On multivariate analysis, co-expression of OCT-2/BOB.1 remained predictive for achievement of complete remission and increased risk of relapse. PMID: 20141429
    10. BOB.1 may be helpful marker in the differential diagnosis of classical Hodgkin's lymphoma and primary mediastinal B-cell lymphoma PMID: 20102401
    11. The expression of the octamer cofactor gene OBF-1 (Bob1/OCA-B) is sufficient to override the silencing effects of the B29 silencer, indicating that OBF-1 plays a critical role in B cell-specific B29 promoter expression. PMID: 11907094
    12. enhances transcriptional potential of Oct1 PMID: 12727885
    13. OCA-B sustains expression of the immunoglobulin-secreting program when T lymphoma and plasmacytoma lines are fused, requiring Oct-2 coregulator for its function. PMID: 14662861
    14. POU2AF1 was observed to be differentially expressed in the cells of patients with chronic lymphocytic leukemia. PMID: 15672409
    15. Alteration of the BOB1 locus does not correlate with its suppressed expression in Hodgkin lymphoma. PMID: 15796964
    16. Novel germ cell markers BOB1 were significantly upregulated in seminoma specimens, compared to normal testes. PMID: 17785371
    17. Oct-2 and its cofactor Bob-1 have an important function in mediating the IgH enhancer-bcl-2 promoter region interactions PMID: 18695675

    顯示更多

    收起更多

  • 相關疾?。?/div>
    A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    POU2AF1 family
  • 組織特異性:
    B-cell specific. Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine.
  • 數據庫鏈接:

    HGNC: 9211

    OMIM: 601206

    KEGG: hsa:5450

    STRING: 9606.ENSP00000376786

    UniGene: Hs.654525



主站蜘蛛池模板: 成人无码午夜在线观看| 国产真实野战在线视频| 成人亚洲欧美久久久久| 久久久久久好爽爽久久| 成人精品一区日本无码网| 欧美亚洲国产成人一区二区三区 | 天天狠天天透天干天干| 日本熟妇hdsex视频| 亚洲欧美第一成人网站7777| 国产人妻一区二区三区久| 久久免费午夜福利院| 蜜臀av色欲a片无码一区| av片在线播放| 好湿好紧太硬了我太爽了视频| 亚洲欧洲日产国码韩国| 国内精品自在自线视频| 毛片内射久久久一区| 成人欧美一区二区三区在线观看| 18禁真人抽搐一进一出在线| 黄页网站视频免费大全| 亚州av综合色区无码一区| 精品国产一区二区三区色欲| 国产午夜亚洲精品理论片不卡| 把女邻居弄到潮喷的性经历| 99久久婷婷国产综合精品电影| 激情偷乱人伦小说视频| 狠狠综合久久久久尤物| 国产 | 久你欧洲野花视频欧洲1| 亚洲中文无码a∨在线观看| 丰满人妻被黑人中出849| 亚洲一区av无码专区在线观看| 国产一区二区三区四区五区加勒比| 日韩人妻无码一区二区三区综合| 一边吃奶一边添p好爽高清视频| 胸大美女又黄的网站| 色综合天天综合网中文| 精品成人毛片一区二区| 国产在线无码一区二区三区视频 | 久久午夜无码鲁丝片秋霞| 国产美女视频免费观看网址| 久久久久高潮综合影院|