在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PORCN Antibody, Biotin conjugated

  • 中文名稱:
    PORCN兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA887958LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PORCN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DHOF antibody; FODH antibody; MG61 antibody; MGC29687 antibody; por antibody; PORC antibody; PORCN antibody; PORCN_HUMAN antibody; PPN antibody; Probable protein-cysteine N-palmitoyltransferase porcupine antibody; Protein MG61 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein-serine O-palmitoleoyltransferase porcupine protein (269-332AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors.
  • 基因功能參考文獻:
    1. Case Report: mosaicism for PORCN mutations in focal dermal hypoplasia (Goltz Syndrome). PMID: 28293688
    2. Data suggest that PORCN exhibits substrate specificity that includes a Wnt3a peptide fragment (residues 199-219, with disulfide bonds); recombinant PORCN containing a point mutation (R228C) associated with focal dermal hypoplasia exhibits impaired acylation activity toward Wnt3a peptide fragment. (PORCN = porcupine O-acyltransferase; Wnt3a = Wnt family member 3A) PMID: 28655768
    3. Inhibition of Wnt signaling by PORCN inhibition holds promise as differentiation therapy in genetically defined human cancers PMID: 26257057
    4. porcupine-mediated production of Wnts is context dependent and is not required for all Wnts production, suggesting that alternative mechanisms exist for Wnts production. PMID: 24647048
    5. We describe the first case of non-mosaic males affected with syndromic microphthalmia because of a non-synonymous variant in the PORCN gene. PMID: 25026905
    6. the Wnt amino acid residues required for recognition and palmitoylation by PORCN PMID: 25451226
    7. We describe the ophthalmologic findings in an 18-month-old boy with mosaicism of a novel mutation in PORCN. PMID: 24698628
    8. a novel variant in the PORCN gene (c.1250T>C:p.F417S) in the focal dermal hypoplasia with spinal anomaly PMID: 23696273
    9. We report a typical focal dermal hypoplasia (FDH) patient with a recurrent PORCN mutation, which was previously identified, and a second female, with an almost unilateral FDH and a novel postzygotic PORCN mutation. PMID: 23399492
    10. To the best of our knowledge, this is the second case report that reveals a mutation of the PORCN gene in a patient with almost unilateral focal dermal hypoplasia. PMID: 22735390
    11. PORCN protein thus appears to moonlight in a novel signaling pathway that is rate-limiting for cancer cell growth and tumorigenesis independent of its enzymatic function in Wnt biosynthesis and secretion PMID: 22509316
    12. review of the published mutations in the PORCN gene and report on 7 new mutations identified in Goltz-Gorlin syndrome patients PMID: 21472892
    13. 12 novel PORCN mutations and 6 previously reported mutations were found in 53 unrelated focal dermal hypoplasia patients. PMID: 20854095
    14. Porcupine might contribute to non-small cell lung carcinoma development by ranscriptional activation of cancer-related genes such as s100P. PMID: 20198348
    15. Three de novo mutations were identified in PORCN gene in patients with focal dermal hypoplasia. PMID: 19863546
    16. Sequence deletions and point mutations cause focal dermal hypoplasia. PMID: 17546030
    17. PORCN, encoding a putative O-acyltransferase potentially crucial for cellular export of Wnt signaling proteins, is the gene mutated in focal dermal hypoplasia. PMID: 17546031
    18. Overexpression of PORCN is associated with lung cancer PMID: 18193088
    19. 3 novel mutations in PORCN, c.373+1G>A, c.737_738insA & c.1094G>A (p.R365Q), were identified in focal dermal hypoplasia patients(FDH); study shows PORCN is gene responsible for FDH in different populations & extends number of confirmed mutations to 26 PMID: 18325042
    20. defective PORCN does not lead to selective growth disadvantage PMID: 19277062
    21. Molecular characterization of 24 unrelated patients from different ethnic backgrounds revealed 23 different mutations of the PORCN gene in Xp11.23. PMID: 19309688
    22. Mutations within the PORCN gene are associated with Goltz-Gorlin syndrome. PMID: 19586929
    23. Focal dermal hypoplasia illustrates the phenotypic consequences of defective modulation of Wnt signaling in utero and highlights the important roles of PORCN and Wnt signaling pathways in embryogenesis. PMID: 19681149

    顯示更多

    收起更多

  • 相關疾病:
    Focal dermal hypoplasia (FODH)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Membrane-bound acyltransferase family, Porcupine subfamily
  • 組織特異性:
    Isoform 1 is expressed in fetal brain, brain, amygdala, caudate nucleus, cerebellum, hippocampus, pituitary, thalamus, heart, skeletal muscle and testis. Isoform 4 is expressed in amygdala, corpus callosum, hippocampus, spinal cord, kidney, liver, lung, s
  • 數據庫鏈接:

    HGNC: 17652

    OMIM: 300651

    KEGG: hsa:64840

    STRING: 9606.ENSP00000322304

    UniGene: Hs.386453



主站蜘蛛池模板: 久久精品99国产国产精| 国产又大又粗又爽的毛片| 久久精品噜噜噜成人| 无码午夜成人1000部免费视频| 久青草影院在线观看国产| 久久精品国产国产精品四凭| 手机国产乱子伦精品视频| 亚洲精品一区二区久久| 天堂av男人在线播放| 一二三四视频在线观看日本| 日日碰狠狠添天天爽五月婷| 少妇高潮喷水惨叫久久久久电影| 国产精品v片在线观看不卡| 亚洲精品天堂成人片av在线播放 | 蜜臀av性久久久久蜜臀aⅴ| 欧美一区二区三区成人久久片| 日韩精品无码一区二区中文字幕| 亚洲国产欧美在线人成人| 在线看片免费人成视频在线影院| 亚洲中文字幕日产无码2020 | 中文字幕乱码熟女人妻水蜜桃| 脱了美女内裤猛烈进入gif| 波多野结衣中文字幕久久| 中文文字幕文字幕亚洲色| 国产乱人伦av在线a最新| 国产成人一区二区不卡免费视频| 国产色视频一区二区三区qq号| 色偷一区国产精品| 亚洲精品一区二区三区麻豆| 天堂亚洲国产中文在线| 亚洲 国产 韩国 欧美 在线| 亚洲永久精品ww47| 麻花传媒剧国产mv高清播放| 加勒比中文无码久久综合色| 国产xxxx99真实实拍| аⅴ天堂中文在线网官网| 精品亚洲成a人在线观看青青| 一区二区三区在线 | 日| 日本熟妇浓毛hdsex| 永久免费精品精品永久-夜色| 精品国内自产拍在线观看|