在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POLRMT Antibody

  • 中文名稱:
    POLRMT兔多克隆抗體
  • 貨號:
    CSB-PA018353LA01HU
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA018353LA01HU diluted at 1:400 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POLRMT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    POLRMT
  • 別名:
    APOLMT antibody; DNA-directed RNA polymerase antibody; DNA-directed RNA polymerase mitochondrial antibody; h-mtRPOL antibody; mitochondrial antibody; MTRNAP antibody; MtRPOL antibody; POLRMT antibody; polymerase (RNA) mitochondrial (DNA directed) antibody; polymerase, RNA, mitochondrial antibody; RPOM antibody; RPOM_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DNA-directed RNA polymerase, mitochondrial protein (282-405AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,POLRMT Antibody (CSB-PA018353LA01HU),的標記方式是Non-conjugated。對于POLRMT Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA018353LB01HU POLRMT Antibody, HRP conjugated ELISA
    FITC CSB-PA018353LC01HU POLRMT Antibody, FITC conjugated
    Biotin CSB-PA018353LD01HU POLRMT Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand.
  • 基因功能參考文獻:
    1. the frequency of variation in sequence identity and length at conserved sequence block 2 amongst human mitochondrial genomes and used in vitro transcription to assess the effects of this length heterogeneity on the activity of the mitochondrial RNA polymerase, POLRMT, was examined. PMID: 27436287
    2. Suggest targeting POLRMT as strategy for treating acute myeloid leukemia. PMID: 26484416
    3. knock-down of MRPL12 by RNA interference results in instability of POLRMT. PMID: 26586915
    4. Results show that polymorphisms at POLG2 and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes. PMID: 26403317
    5. The results reveal the organization of TFAM, POLRMT and TFB2M around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex. PMID: 24413562
    6. The results demonstrate that human TFAM binds to the N-terminal domain of mtRNAP, which results in bending of the promoter DNA around mtRNAP. PMID: 24393772
    7. Newly synthesized RNA exits toward the pentatricopeptide repeat (PPR) domain, a unique feature of mtRNAP with conserved RNA-recognition motifs. PMID: 24096365
    8. Authors propose that POLRMT interacts directly with h-mtTFB1 in 28S mitochondrial ribosomes to augment its 12S rRNA methyltransferase activity. PMID: 23303773
    9. X-ray structure of human mtRNAP at 2.5 A resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain resembling the T7 promoter-binding domain, a novel pentatricopeptide repeat domain, and flexible N-terminal extension PMID: 21947009
    10. muscle actin genes are transcribed by nuclear isoform of mitochondrial RNA polymerase (spRNAP-IV) whereas the non-muscle actin genes are transcribed by the conventional RNA polymerase II (PolII) PMID: 21799907
    11. Human mitochondrial RNA polymerase: evaluation of the single-nucleotide-addition cycle on synthetic RNA/DNA scaffolds PMID: 21548588
    12. POLRMT can function as an origin-specific primase in mammalian mitochondria. PMID: 20129056
    13. human mitochondrial DNA polymerase has a role in autosomal dominant progressive external ophthalmoplegia PMID: 15258572
    14. POLRMT recognizes promoter elements in a sequence specific manner; TFAM induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition PMID: 15526033
    15. transcription of some mRNAs in humans and rodents is mediated by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV), expressed from an alternative transcript of the mitochondrial RNA polymerase gene POLRMT PMID: 16079853
    16. the MRPL12 interaction with POLRMT is likely part of a novel regulatory mechanism that coordinates mitochondrial transcription with translation PMID: 17337445
    17. Promoter-independent DNA conformation-dependent transcription required TFB2M and was suppressed by TFAM, while promoter-dependent transcription was inhibited to a lesser extent BY TFAM. PMID: 19624753

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    Phage and mitochondrial RNA polymerase family
  • 數據庫鏈接:

    HGNC: 9200

    OMIM: 601778

    KEGG: hsa:5442

    STRING: 9606.ENSP00000215591

    UniGene: Hs.254113



主站蜘蛛池模板: 新婚少妇无套内谢国语播放| 人妻出差精油按摩被中出| 国产午夜无码片在线观看网站| 在线亚洲中文精品第1页| 国产在线精品一区二区中文| 午夜精品久久久久久中宇| 精品久久久久久综合日本| 久久影院九九被窝爽爽| 国产成人综合在线女婷五月99播放 | 国产精品自在在线午夜| 久久久久久亚洲精品成人| 日韩人妻无码精品专区综合网| 夜夜躁狠狠躁日日躁视频| 国产激情艳情在线看视频 | 一区二区三区国产亚洲网站| 精品日产卡一卡二卡麻豆| 2020久久超碰国产精品最新| 亚洲精品毛片一区二区三区| 一本一道波多野结衣av黑人| 国产精品成人嫩草影院| 成年站免费网站看v片在线| 色香欲综合成人免费视频| 日本不卡高字幕在线2019| 青青草无码免费一二三区| 国产精品日本亚洲777| 伊人久久综合色| 国产一区二区三区四区五区加勒比| 国产国产久热这里只有精品| 国精产品蘑菇一区一区有限| 国产sm重味一区二区三区| 女人被狂躁c到高潮| 亚洲国产欧美一区二区好看电影| 国产亚洲日韩av在线播放不卡 | 亚洲热妇无码av在线播放| 午夜影视免费| 成人免费视频一区二区| 热久久99这里有精品综合久久| 2021久久国自产拍精品| 精品人妻中文无码av在线| 成年片色大黄全免费软件到| 亚洲自偷自拍另类12p|