在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. POLR3B Antibody

POLR3B Antibody

  • 中文名稱：
    POLR3B兔多克隆抗體
  • 貨號：
    CSB-PA592018
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from LOVO cells, using RPC2 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) POLR3B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    POLR3B
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human RPC2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
  • 基因功能參考文獻：
    1. Novel compound heterozygous variations in POLR3B were identified in a patient with cerebellar hypoplasia with endosteal sclerosis. PMID: 28589944
    2. The spectrum of phenotypes resulting from POLR3B mutations is wider than previously believed. PMID: 27512013
    3. Findings suggest that AP-1 factors are regulators of RNA polymerase III (Pol III)-driven 5S rRNA and U6 snRNA expression with a potential role in cell proliferation. PMID: 28488757
    4. Multicenter retrospective study to collect neuroradiologic, clinical, and molecular data of patients with mutations in POLR3A and POLR3B without the classic MRI phenotype: diffuse hypomyelination is not an obligatory feature of POLR3-related disorders; two distinct patterns, selective involvement of the corticospinal tracts and cerebellar atrophy, are added to the MRI presentation of POLR3-related disorders PMID: 27029625
    5. first reports of long deletions causing POLR3-related leukodystrophy, suggesting that deletions and duplications in POLR3A or POLR3B should be investigated in patients with a compatible phenotype PMID: 26045207
    6. Mutations in POLR3A or POLR3B are rare in patients with unclassified hypomyelination. PMID: 26011300
    7. INMAP as a model regulator of CENP-B PMID: 24633075
    8. These results suggest that INMAP might function through p53/p21 pathways. PMID: 25635878
    9. Most patients with 4H leukodystrophy carried the common c.1568T>A POLR3B mutation on one allele. PMID: 25339210
    10. MRI in patients with POLR3B mutations revealed smaller cerebellar structures, especially vermis, than those in POLR3A mutations. MRI also showed milder hypomyelination in patients with POLR3B mutations than those with POLR3A mutations PMID: 23643445
    11. Investigated POLR3A and POLR3B mutations in patients with genetically unexplained hypomyelinating leukodystrophies with features of Pol III-related leukodystrophies. Recessive mutations in POLR3A or POLR3B were uncovered in all 14 patients. PMID: 23355746
    12. study reports INMAP is a truncated version of POLR3B, and is up-regulated in several human cancer cell lines; results suggest that INMAP may function through the p53 and AP-1 pathways, providing a possible link of its activity with tumourigenesis PMID: 23124897
    13. Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy PMID: 22036171
    14. Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy PMID: 22036172
    15. Results suggest that INMAP is a novel protein that plays essential role in spindle formation and cell-cycle progression. PMID: 19331820
    16. Data describe the purification and identification of RNA polymerase III subunits RPC2 and RPC5. PMID: 12391170

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism (HLD8)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    RNA polymerase beta chain family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30348

    OMIM: 614366

    KEGG: hsa:55703

    STRING: 9606.ENSP00000228347

    UniGene: Hs.610795



主站蜘蛛池模板： 国产男女猛烈无遮挡免费网站| 久久久久久夜精品精品免费啦 | 99精品国产兔费观看久久99| 人妻熟女一区二区aⅴ图片| 国产强伦姧在线观看无码| 亚洲国产另类久久久精品| 中文字幕乱码人妻一区二区三区| 在线观看免费视频污网站| 欧美日韩精品成人网站二区| 草的我好爽视频| 中文在线а天堂中文在线新版| 国产精品一区二区香蕉| 中文日产幕无线码6区收藏| 国产成人片无码视频在线观看| 久久久久噜噜噜亚洲熟女综合| 免费国产乱理伦片在线观看| 欧美丰满熟妇xxxx性ppx人| 日日噜噜噜噜夜夜爽亚洲精品 | 免费毛片在线看片免费丝瓜视频| 国产一在线精品一区在线观看| 初尝人妻少妇中文字幕| av一区二区三区人妻少妇| 欧洲美熟女乱又伦av| 免费三级网站| 人人鲁人人莫人人爱精品| 国产99久久久国产无需播放器 | 男女真人国产牲交a做片野外 | 女人下边被添全过视频的网址| 精品av国产一二三四区| 人妻无码一区二区三区tv| 欧美国产亚洲日韩在线二区| 性做久久久久久久久| 国产97在线 | 日韩| 2019亚洲午夜无码天堂| 性xxxx欧美老妇506070| 国产69精品久久久久久久| 亚洲日本一区二区三区在线播放| 潮喷大喷水系列无码| 色一情一乱一伦一区二区三区日本| 天天综合亚洲色在线精品| 午夜国产亚洲精品一区|