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  4. POLR2E Antibody

POLR2E Antibody

  • 中文名稱：
    POLR2E兔多克隆抗體
  • 貨號：
    CSB-PA030118
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    POLR2E
  • 別名：
    and III subunit ABC1 antibody; and III subunit RPABC1 antibody; DNA directed RNA polymerase II 23 kda polypeptide antibody; DNA directed RNA polymerase II 23 kDa polypeptide antibody; DNA directed RNA polymerase II polypeptide E antibody; DNA directed RNA polymerase II subunit E antibody; DNA directed RNA polymerases I II and III subunit RPABC1 antibody; DNA-directed RNA polymerase II 23 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit E antibody; DNA-directed RNA polymerases I antibody; hRPB25 antibody; hsRPB5 antibody; II antibody; Polr2e antibody; Polymerase (RNA) II (DNA directed) polypeptide E (25kD) antibody; Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa antibody; RNA polymerases I antibody; RNA polymerases I, II, and III subunit ABC1 antibody; RPAB1_HUMAN antibody; RPABC1 antibody; RPB5 antibody; RPB5 homolog antibody; XAP4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human POLR2E.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.
  • 基因功能參考文獻：
    1. POLR2E rs3787016T allele was associated with an increased cancer risk in Chinese population PMID: 29724531
    2. POLR2E rs3787016 C/T and HULC rs7763881 were associated with a significantly decreased risk for ESCC 0.005). ANRIL rs2151280 T/C SNP was not associated with risk of ESCC. PMID: 25874495
    3. ELL has an early and essential role during rapid high-amplitude gene expression that is required for both Pol II pause site entry and release PMID: 22252557
    4. crystal of RPB5 diffracted to 2.8 A resolution and belonged to space group P4(3)2(1)2. PMID: 22102239
    5. RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells. PMID: 21310960
    6. Results pinpoint critical residues for RNA polymerase II subunit 5 binding to RAP30 and/or to HBx, and identify these residues in both mammalian cells and in an in vitro binding assay. PMID: 16169872

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9192

    OMIM: 180664

    KEGG: hsa:5434

    STRING: 9606.ENSP00000215587

    UniGene: Hs.24301



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