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  4. POLR1C Antibody

POLR1C Antibody

  • 中文名稱：
    POLR1C兔多克隆抗體
  • 貨號：
    CSB-PA080019
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    POLR1C
  • 別名：
    40kDa antibody; AA409007 antibody; AA959927 antibody; Ac2-127 antibody; AC40 antibody; AL024089 antibody; DNA directed RNA polymerase I subunit C antibody; DNA directed RNA polymerases I and III 40 kDa polypeptide antibody; DNA directed RNA polymerases I and III subunit RPAC1 antibody; DNA-directed RNA polymerase I subunit C antibody; DNA-directed RNA polymerases I and III 40 kDa polypeptide antibody; DNA-directed RNA polymerases I and III subunit RPAC1 antibody; MGC105583 antibody; MGC161175 antibody; POLR1C antibody; POLR1E antibody; Polymerase (RNA) I polypeptide C, 30kDa antibody; RNA polymerase 1 1 antibody; RNA polymerase I subunit C antibody; RNA polymerases I and III subunit AC1 antibody; RP3-337H4.4 antibody; RPA39 antibody; RPA40 antibody; RPA5 antibody; RPAC1 antibody; RPAC1_HUMAN antibody; RPC40 antibody; Rpo1 1 antibody; TCS3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human RPA40.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
  • 基因功能參考文獻：
    1. Treacher Collins syndrome 3-associated mutation leads to the localization of POLR1C into the lysosome and inhibits chondrogenic differentiation, possibly explaining a portion of the pathological molecular basis underlying Treacher Collins syndrome. PMID: 29567474
    2. This study is the first to show that distinct mutations in a gene coding for a shared subunit of two RNA polymerases lead to selective modification of the enzymes' availability leading to two different clinical conditions. PMID: 26151409
    3. Mutations in TCOF1, POLR1C and POLR1D have all been implicated in causing TCS PMID: 24690222
    4. mutations in both alleles of POLR1C in three individuals with Treacher Collins syndrome. PMID: 21131976
    5. analyzed the kinetics of assembly and elongation of the RNA polymerase I complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy PMID: 12446911

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  • 相關疾病：
    Treacher Collins syndrome 3 (TCS3); Leukodystrophy, hypomyelinating, 11 (HLD11)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family
  • 數據庫鏈接：

    HGNC: 20194

    OMIM: 248390

    KEGG: hsa:9533

    STRING: 9606.ENSP00000361465

    UniGene: Hs.743509



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