在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POLI Antibody, Biotin conjugated

  • 中文名稱:
    POLI兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA892157LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POLI Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DNA polymerase iota antibody; Eta 2 antibody; Eta2 antibody; POLI antibody; POLI_HUMAN antibody; Polymerase (DNA directed) iota antibody; RAD 30B antibody; RAD30 homolog B antibody; RAD30, S. cerevisiae, homolog of antibody; RAD30B antibody; RAD3OB antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DNA polymerase iota protein (458-711AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
  • 基因功能參考文獻:
    1. Findings indicate that DNA polymerase iota (poli) plays a positive role in lung cancer progression via promoting the migration and invasion of lung cancer cells. PMID: 30060029
    2. Findings indicate the function of tumor suppressor protein p53 (p53) and DNA polymerase iota (POLiota) in the DNA damage response to endogenous or exogenous replication stress. PMID: 27407148
    3. DNA polymerase iota increased the expression of MMP-2/9 to promote invasion and metastasis of esophageal squamous cell carcinoma. PMID: 27057634
    4. The predominant isoform of DNA poliota in human cells is the shorter 715 amino acid protein and that if, or when, expressed, the longer 740 amino acid isoform has identical properties to the considerably more abundant shorter isoform. PMID: 28865289
    5. Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota. PMID: 27555320
    6. Mass spectrometry analysis of monoubiquitinated poliota revealed that it is ubiquitinated at over 27 unique sites. Many of these sites are localized in different functional domains of the protein. PMID: 26370087
    7. Germline genetic variations in human POLI gene may either hinder or promote the translesion synthesis (TLS) capability of pol iota with various DNA lesions in vitro, emphasizing the potential translational importance of these pol iota genetic variations, e.g., individual differences in TLS, mutation, and cancer susceptibility to genotoxic carcinogens. PMID: 25162224
    8. a single residue in pol iota is able to discriminate between NTPs and dNTPs during DNA synthesis. PMID: 24532793
    9. Dysregulation of pol iota by JNK/c-Jun is involved in carcinogenesis and offer a novel understanding of the role of pol iota or c-Jun in mutagenesis. PMID: 23922701
    10. Human Pol iota and yeast Pol zeta complex could function efficiently in the insertion and extension steps, respectively, of ranslesion synthesis and human Pol kappa and Pol eta could also extend past these lesions, albeit much less efficiently. PMID: 23965998
    11. POLI and MC4R nearby single nucleotide polymorphisms in human chromosome 18 are associated with a moderate risk of type 2 diabetes. PMID: 23727064
    12. Results show that the physical and functional interaction between pols eta and iota occurs between ubiquitinated forms of either polymerase via their respective ubiquitin-binding domains. PMID: 23248005
    13. this review briefly discusses the main structural features and possible functional mechanisms of the active center of Pol iota. [review] PMID: 22817454
    14. in mammalian cells, both polymerases kappa and iota are necessary for the error-free bypass of N(2)-CEdG and N(2)-CMdG. PMID: 21454642
    15. structural mechanism of high-fidelity 8-oxo-G replication by a human DNA polymerase PMID: 21300901
    16. Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota. PMID: 20961860
    17. In the presence of Mn2+, the Pol iota activity in carcinoma was 2.5-fold higher than the control cells. PMID: 20673215
    18. The solution structures of the C-terminal UBM of human pol iota and its complex with ubiquitin are reported. PMID: 20159559
    19. Variants in POLI is associated with predisposition for TMPRSS2-ERG fusion in prostate cancer. PMID: 19861517
    20. DNA polymerase iota's versatility implies that this enzyme can adjust to local structural conditions in order to bypass bulky lesions by strategies that utilize Watson-Crick, Hoogsteen and perhaps other base pairing possibilities. PMID: 19767609
    21. By performing gene inactivation in a Burkitt's lymphoma cell line inducible for hypermutation, we show here that somatic hypermutation is dependent on DNA polymerase iota PMID: 12410315
    22. DNA polymerase iota associates with the replication machinery & accumulates at stalled replication forks following DNA-damaging treatment. Its the C-terminal 224 AAs are sufficient for both the interaction with poleta & accumulation in replication foci. PMID: 12426396
    23. Translesion replication of benzo[a]pyrene and benzo[c]phenanthrene diol epoxide adducts of deoxyadenosine and deoxyguanosine by DNA polymerase iota. PMID: 12466554
    24. pol iota can complement the in vitro single-nucleotide BER deficiency of a DNA polymerase beta null cell extract PMID: 12777390
    25. propose that the incipient base pair is accommodated differently in the active site of Poliota dependent upon the template base and that when T is the templating base, Poliota accommodates the wobble base pair better than the Watson-Crick base pair PMID: 14701763
    26. crystal structure bound to a template primer and an incoming nucleotide; structure reveals a polymerase that is 'specialized' for Hoogsteen base-pairing, whereby the templating base is driven to the syn conformation PMID: 15254543
    27. Data strongly suggest that pol iota may be involved in the generation of both increased spontaneous and translesion mutations during DNA replication in breast cancer cells, thereby contributing to the accumulation of genetic damage. PMID: 15313897
    28. Data show that an interaction between human DNA polymerase iota (poliota) and the proliferating cell nuclear antigen (PCNA) stimulates the processivity of poliota in a template-dependent manner in vitro. PMID: 15342632
    29. Poliota interacts with PCNA via only one of its conserved PCNA binding motifs, regardless of whether PCNA is bound to DNA or not. PMID: 15657443
    30. DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA PMID: 16166652
    31. The sequential action of Poliota and Polkappa promotes efficient and error-free synthesis through the HNE-dG adducts. PMID: 16354708
    32. identification of two previously unknown ubiquitin-binding domains in the Y-family translesion synthesis polymerases that enable them to interact with monoubiquitinated targets and undergo monoubiquitination in vivo PMID: 16357261
    33. results show that Pol iota has no significant role in UV lesion bypass and mutagenesis in vivo and provides some initial data suggesting that this polymerase may be involved in replication of extrachromosomal DNA PMID: 16472831
    34. polymerization by pol iota is severely inhibited by a bulky group at G N2 despite an advantageous mode of Hoogsteen base pairing PMID: 16527824
    35. DNA polymerases iota and eta interact noncovalently with free polyUb chains, as well as mono-ubiquitinated proliferating cell nuclear antigen (Ub-PCNA). PMID: 16763556
    36. For proficient T incorporation opposite template A, only the N7 hydrogen bonding is required, but for proficient C incorporation opposite template G, hydrogen bonding at both the N7 and O(6) is an imperative. PMID: 16914729
    37. These results suggest that HIF-1-mediated pol iota gene expression may be involved in the generation of translesion mutations during DNA replication after hypoxia followed by reoxygenation. PMID: 17056006
    38. the cation utilized by pol iota in vivo may actually be Mn(2+) rather than Mg(2+), as tacitly assumed PMID: 17609217
    39. Data suggest that DNA polymerases eta and iota transiently probe DNA/chromatin; when DNA is exposed at replication forks, the polymerase residence times increase, and this is further facilitated by the ubiquitination of PCNA. PMID: 18799611
    40. These data reveal a novel role of human DNA pol iota in protecting cells from oxidative damage. PMID: 18923427
    41. Lesion bypass of N2-ethylguanine by human DNA polymerase iota. PMID: 18984581
    42. enzyme plays important functions in protecting humans from the deleterious consequences of exposure to both oxidative- and ultraviolet light-induced DNA damage PMID: 19162565
    43. DNA synthesis across an absaic lesion by human POLI is reported. PMID: 19368886
    44. Structural and domain-swapping experiments indicate that the finger domain is responsible for DNA polymerase iota's high error rates on pyrimidines and determines the incorporation specificity. PMID: 19440206
    45. Replication across template T/U by human DNA POLI is reported. PMID: 19604477

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    DNA polymerase type-Y family
  • 組織特異性:
    Ubiquitous. Highly expressed in testis.
  • 數據庫鏈接:

    HGNC: 9182

    OMIM: 605252

    KEGG: hsa:11201

    STRING: 9606.ENSP00000462664

    UniGene: Hs.438533



主站蜘蛛池模板: 狠狠cao日日穞夜夜穞av| 少妇与黑人一二三区无码| 日韩精品乱码av一区二区| 亚洲国产欧美一区点击进入| 亚洲va天堂va欧美片a在线| 久久精品亚洲乱码伦伦中文 | 国产成人无码精品久久涩吧| 亚洲精品无码鲁网中文电影| 国产精品视频一区二区噜噜| 少妇高潮喷水久久久影院| 国产精品久久久久久久久久久久午衣片 | 欧美国产日韩亚洲中文| 久久久久国色av免费观看| 亚洲成av人片在www色猫咪| 久久国产色av免费看| 国内大量揄拍人妻在线视频| 国产亚洲熟妇综合视频| 99久久精品费精品国产| 一日本道a高清免费播放| 亚洲午夜精品一区二区| 国产蜜芽尤物在线一区| 无码午夜人妻一区二区不卡视频| 天天狠天天透天天伊人| 看曰本女人大战黑人视频| 亚洲精品卡2卡3卡4卡5卡区| 本道久久综合无码中文字幕| 把女邻居弄到潮喷的性经历| 亚洲日韩乱码一区二区三区四区| 在线视频精品免费观看10| 国内精品久久久久影院优| 国产性色αv视频免费| 欧美老人巨大xxxx做受视频| 无码国产欧美一区二区三区不卡 | 欧美亚洲国产一区二区三区 | 天干夜啦天干天干国产免费| 2019亚洲午夜无码天堂| 小嫩妇好紧好爽18禁视频| 欧美精品高清在线观看| 少妇挑战黑人高潮惨叫| 亚洲а∨天堂久久精品| 成人性做爰aaa片免费|