在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

POLD2 Antibody, FITC conjugated

  • 中文名稱:
    POLD2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA018304LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) POLD2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DNA polymerase delta subunit 2 antibody; DNA polymerase delta subunit p50 antibody; DNA polymerase subunit delta 2 antibody; DNA polymerase subunit delta p50 antibody; DPOD2_HUMAN antibody; POLD 2 antibody; pold2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human DNA polymerase delta subunit 2 protein (245-430AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7.
  • 基因功能參考文獻:
    1. The results show that the FF483-484 amino acids in the human Poleta (designated F1 motif) are necessary for the interaction of this polymerase with POLD2, the B subunit of the replicative DNA polymerase delta, both in vitro and in vivo. PMID: 25662213
    2. DNA polymerase delta catalytic subunit p125 induced by mutant type p53 is associated with hepatocellular carcinoma invasion. PMID: 21372597
    3. Results suggest that POLD2 and KSP37 might be potential prognostic biomarkers. PMID: 21079801
    4. The association of PDIP38 with pol delta was shown to occur in calf thymus tissue and mammalian cell extracts by GST-PDIP38 pull-down and coimmunoprecipitation experiments. PMID: 12522211
    5. As a first step towards understanding the functional importance of their regulatory subunit interactions, the three-dimensional structure of the p50-p66 heterodimer of human Pol delta has been solved using X-ray crystallography. PMID: 18765914
    6. the crystal structure of p50*p66(N) complex featuring oligonucleotide binding and phosphodiesterase domains in p50 PMID: 18818516

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    DNA polymerase delta/II small subunit family
  • 數據庫鏈接:

    HGNC: 9176

    OMIM: 600815

    KEGG: hsa:5425

    STRING: 9606.ENSP00000386105

    UniGene: Hs.306791



主站蜘蛛池模板: 国产日产精品久久快鸭的功能介绍| 国产∨亚洲v天堂无码久久久| 国产精品国产三级在线...| 亚洲欧美日韩另类精品一区| 亚洲国产日韩欧美综合a| 无码国内精品久久人妻 | 色哟哟最新在线观看入口| 中文字幕一区二区三区乱码| 性视频播放免费视频| 少妇愉情理伦片高潮日本| 欧美毛多水多黑寡妇| 国产又粗又黄又爽的大片| 国产精品亚洲аv久久| 日本japanese丰满少妇| 欧美三级欧美成人高清| 国产精品久久久久久免费软件| 色哟哟免费视频播放网站| 色综合伊人丁香五月桃花婷婷| 国产精品欧美亚洲韩国日本久久| 国产精品96久久久久久| 亚洲一区二区三区在线观看网站| 日本久久夜夜一本婷婷| 久久久精品一区aaa片| 老熟妇仑乱视频一区二区| 成人爱做日本视频免费| 国产精成a品人v在线播放 | 国产成人精品永久免费视频| 无码纯肉动漫在线观看| 欧洲成人午夜精品无码区久久| 国产高清成人免费视频在线观看| 久久久中文字幕日本无吗| 日本免费更新一二三区不卡| av天堂午夜精品蜜臀av| 97久久精品人妻人人搡人人玩| 艳妇臀荡乳欲伦69调教视频| 国产情侣草莓视频在线| 国内精品久久久久久影院8f| 亚洲国产成人久久综合| 国产精品亚洲专区无码不卡| 无码吃奶揉捏奶头高潮视频| 亚洲男人的天堂成人www|