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  4. POGZ Antibody, HRP conjugated

POGZ Antibody, HRP conjugated

  • 中文名稱：
    POGZ兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA018299LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) POGZ Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    POGZ
  • 別名：
    KIAA0461 antibody; MGC71543 antibody; Pogo transposable element with ZNF domain antibody; POGZ antibody; POGZ_HUMAN antibody; putative protein product of Nbla00003 antibody; SUHW5 antibody; suppressor of hairy wing homolog antibody; Suppressor of hairy wing homolog 5 antibody; Zinc finger protein 280E antibody; Zinc finger protein 635 antibody; ZNF280E antibody; ZNF635 antibody; ZNF635M antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Pogo transposable element with ZNF domain protein (1-300AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms.
  • 基因功能參考文獻：
    1. In silico analysis and western blotting revealed this frameshift mutation generating truncated protein in peripheral blood lymphocytes, and this may disrupt several important domains of POGZ gene. Our finding broadens the spectrum of POGZ mutations and may help to understand the molecular basis of Intellectual disability (ID) and aid genetic counseling. PMID: 26763879
    2. Data suggest that loss of function variants in POGZ lead to an identifiable syndrome of neurodevelopmental disorders with specific phenotypic traits including intellectual disability. PMID: 26739615
    3. We find that POGZ is constitutively expressed across most tissues and has significantly higher levels of expression in the cerebellum and the pituitary gland. Disruption of POGZ is associated with intellectual disability and autism spectrum disorders PMID: 26942287
    4. The results reveal POGZ as an essential protein that links HP1alpha dissociation with Aurora B kinase activation during mitosis. PMID: 20562864
  • 相關疾病：
    White-Sutton syndrome (WHSUS)
  • 亞細胞定位：
    Nucleus. Chromosome. Cytoplasm.
  • 數據庫鏈接：

    HGNC: 18801

    OMIM: 614787

    KEGG: hsa:23126

    STRING: 9606.ENSP00000271715

    UniGene: Hs.489873



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