在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNRC2 Antibody

  • 中文名稱:
    PNRC2兔多克隆抗體
  • 貨號:
    CSB-PA018290GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PNRC2
  • 別名:
    0610011E17Rik antibody; D4Bwg0593e antibody; FLJ20312 antibody; MGC11707 antibody; MGC93828 antibody; MGC99541 antibody; OTTMUSP00000010360 antibody; OTTMUSP00000010366 antibody; pnrc2 antibody; PNRC2_HUMAN antibody; Proline rich nuclear receptor coactivator 2 antibody; Proline-rich nuclear receptor coactivator 2 antibody; RP11-4M23.5 antibody; RP23-161N17.3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Human PNRC2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.
  • 基因功能參考文獻:
    1. UPF1 interacts with PNRC2 and that it triggers 5'-3' exonucleolytic decay of reporter transcripts in tethering assays. PNRC2 is probably an important mRNA decapping factor but that it does not appear to be required for nonsense-mediated mRNA decay. PMID: 29348139
    2. GR and PNRC2 interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation PMID: 25775514
    3. PNRC2 acts in synergy with Dcp1a to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a and Dcp2. PMID: 23085078
    4. Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis. PMID: 14651967
    5. PNRC2 plays an essential role in mammalian Nonsense-mediated mRNA decay (NMD), mediating the interaction between the NMD machinery and the decapping complex. PMID: 19150429

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, P-body.
  • 蛋白家族:
    PNRC family, PNRC2 subfamily
  • 組織特異性:
    Expressed in heart, lung, muscle and brain.
  • 數據庫鏈接:

    HGNC: 23158

    OMIM: 611882

    KEGG: hsa:55629

    STRING: 9606.ENSP00000383587

    UniGene: Hs.512636



主站蜘蛛池模板: 男人添女人下部高潮全视频| 亚洲人成网线在线播放| 国产日韩欧美亚欧在线观看| 亚洲精品无码国产| 97免费人妻在线视频| 免费吃奶摸下激烈视频| 色综合视频一区二区三区| 成人免费无遮挡在线播放| 久久天天躁狠狠躁夜夜2o2o| 精品久久久无码中文字幕| 妺妺窝人体色www在线小说| 午夜片无码区在线观看视频| 久久精品国产亚洲不av麻豆| 又色又爽又黄18禁美女裸身无遮挡| 久久精品无码一区二区三区| 热99re久久精品天堂| 亚洲精品久久久av无码专区| 国产色a在线观看| 日本成aⅴ人片日本伦| 国内裸体无遮挡免费视频| 亚洲国产精品无码专区成人| 国产乱理伦片在线观看| 欧美日韩国产精品自在自线| 久热在线这里只有精品国产| 欧美伊人色综合久久天天| 四虎免费大片aⅴ入口| 日韩av在线观看免费| 又爽又黄又无遮挡网站| 女人扒开屁股爽桶30分钟| 精品免费久久久久久久| 色一情一伦一区二区三| 国产成人av在线一区二区三区 | 国产精品亚韩精品无码a在线 | 国产日韩一区二区三免费高清| 久久久久香蕉国产线看观看伊| 国产女人天天春夜夜春| 国产偷窥熟女高潮精品视频| 欧美丰满熟妇xxxxx| 欧美亚洲日本国产黑白配| 人妻体验按摩到忍不住哀求继续| 卡一卡二卡三免费视频 |