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  4. PNRC2 Antibody

PNRC2 Antibody

  • 中文名稱：
    PNRC2兔多克隆抗體
  • 貨號：
    CSB-PA018290GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PNRC2
  • 別名：
    0610011E17Rik antibody; D4Bwg0593e antibody; FLJ20312 antibody; MGC11707 antibody; MGC93828 antibody; MGC99541 antibody; OTTMUSP00000010360 antibody; OTTMUSP00000010366 antibody; pnrc2 antibody; PNRC2_HUMAN antibody; Proline rich nuclear receptor coactivator 2 antibody; Proline-rich nuclear receptor coactivator 2 antibody; RP11-4M23.5 antibody; RP23-161N17.3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Human PNRC2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.
  • 基因功能參考文獻：
    1. UPF1 interacts with PNRC2 and that it triggers 5'-3' exonucleolytic decay of reporter transcripts in tethering assays. PNRC2 is probably an important mRNA decapping factor but that it does not appear to be required for nonsense-mediated mRNA decay. PMID: 29348139
    2. GR and PNRC2 interact in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation PMID: 25775514
    3. PNRC2 acts in synergy with Dcp1a to stimulate the decapping activity of Dcp2 by bridging the interaction between Dcp1a and Dcp2. PMID: 23085078
    4. Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis. PMID: 14651967
    5. PNRC2 plays an essential role in mammalian Nonsense-mediated mRNA decay (NMD), mediating the interaction between the NMD machinery and the decapping complex. PMID: 19150429

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  • 亞細胞定位：
    Nucleus. Cytoplasm, P-body.
  • 蛋白家族：
    PNRC family, PNRC2 subfamily
  • 組織特異性：
    Expressed in heart, lung, muscle and brain.
  • 數據庫鏈接：

    HGNC: 23158

    OMIM: 611882

    KEGG: hsa:55629

    STRING: 9606.ENSP00000383587

    UniGene: Hs.512636



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