在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNP Antibody

  • 中文名稱:
    PNP兔多克隆抗體
  • 貨號:
    CSB-PA015965GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    PNP
  • 別名:
    FLJ94043 antibody; FLJ97288 antibody; FLJ97312 antibody; Inosine phosphorylase antibody; Inosine-guanosine phosphorylase antibody; MGC117396 antibody; MGC125915 antibody; MGC125916 antibody; NP antibody; Np1 antibody; Nucleoside phosphorylase antibody; PNP antibody; Pnp1 antibody; PNPH_HUMAN antibody; PRO1837 antibody; PUNP antibody; Purine nucleoside orthophosphate ribosyltransferase antibody; Purine nucleoside phosphorylase 5a antibody; Purine nucleoside phosphorylase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NP
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine.
  • 基因功能參考文獻:
    1. The study suggests that mass-constrained femtosecond motions at the catalytic site of PNP can improve transition state barrier crossing by more frequent sampling of essential catalytic site contacts. PMID: 29915028
    2. The PNP rs1049564 T allele is a loss-of-function variant that induces S-phase block and IFN pathway activation in lymphocytes. The S-phase block could be rescued in our in vitro experiments, suggesting the potential for personalized treatment. PMID: 28859258
    3. Data show that the mutations in purine nucleoside phosphorylase (PNP) alters the enthalpy-entropy balance with little effect on the catalytic rates. PMID: 27976868
    4. Data (including data from empirical valence bond/molecular dynamic simulations) suggest that PNP substrate specificity for inosine and guanosine is a direct result of electrostatic preorganization energy along the reaction coordinate. PMID: 26985580
    5. the binding mechanism of a transition state analogue (DADMe-immucillin-H) to the purine nucleoside phosphorylase (PNP) enzyme, is reported. PMID: 25625196
    6. Data show that [15N, 2H]His8-purine nucleoside phosphorylase (PNP) had reduced catalytic site chemistry larger than proportional to the enzymatic mass difference. PMID: 26305965
    7. Study of genetic heterogeneity in systemic lupus erythematosus, the top associations in European ancestry were protein kinase, cyclic GMP-dependent, type I (PRKG1) rs7897633 (P(Meta) = 2.75 x 10(-8)) and purine nucleoside phosphorylase (PNP) rs1049564 (P(Meta) = 1.24 x 10(-7)). PMID: 25338677
    8. Human small intestine is a key site for ribavirin phosphorolysis and that PNP is primarily involved in the metabolism. PMID: 24107682
    9. insufficient data to evaluated impact of genetic polymorphisms on disease susceptibility PMID: 24792412
    10. Complete lack of PNP triggers accumulation of deoxyguanosine, thereby disrupting B-cell development, the consequence of which is more profound with time, as was found in the older sister. PMID: 22578971
    11. Biochemical and genetic data on a cohort of seven patients from six families identified as PNPase deficient, is reported. PMID: 22132981
    12. This study for the first time describes elevated levels of alpha synuclein in pancreatic adenocarcinoma as well as highlights the potential of evaluating NP protein expression. PMID: 21448452
    13. investigation of catalytic mechanisms involved in catalysis by PNP: transition states in arsenolysis and phosphorolysis PMID: 21348499
    14. Results show that some regions, responsible for entrance and exit of substrate, present a conformational variability, which is dissected by dynamics simulation analysis. PMID: 19932753
    15. PNP operating at maximum catalytic potential permits more rapid peptide amide deuterium exchange and greater conformational flexibility of water-peptide bond exchange rate than in either of the complexes with transition state analogues. PMID: 20108972
    16. The optimum pH for PNP from human erythrocytes with xanthosine and xanthine is in the range 5-6, whereas those with guanosine, guanine, inosine & hypoxanthine are in the range 7-8. Possible PNP binding modes of Xan and Xao by mammalian PNPs are proposed. PMID: 12180982
    17. Crystal structure of human purine nucleoside phosphorylase. PMID: 12914785
    18. These data provide a framework in which to conduct genetic association studies of these two genes in relevant populations, thereby allowing hNP and hGSTO1-1 to be evaluated as potential susceptibility genes in human arsenicism. PMID: 12928150
    19. investigation of the quaternary structure of recombinant human purine nucleoside phosphorylase PMID: 13679062
    20. crystal structures in complex with inosine and 2',3'-dideoxyinosine, refined to 2.8A resolution using synchrotron radiation. The structures provide explanation for ligand binding, refine the purine-binding site and can be used for future inhibitor design. PMID: 14706628
    21. several recurring mutations were found in PNP in patients with purine nucleoside phosphorylase deficiency by DNA sequence analysis PMID: 15571269
    22. crystal structure of human PNP in complex with hypoxanthine, refined to 2.6A resoluti PMID: 15582582
    23. findings suggest that the G51S PNP polymorphism is associated with a faster rate of cognitive decline in Alzheimer's disease patients, highlighting the important role of purine metabolism in the progression of this neurodegenerative disorder PMID: 17221831
    24. Role of ionization of the phosphate cosubstrate on phosphorolysis by purine nucleoside phosphorylase PMID: 17639373
    25. Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase. PMID: 18281956
    26. New interactions caused by the mutations increase the catalytic efficiency of the enzyme for formation of a late transition state with increased participation of the phosphate nucleophile. PMID: 18281957
    27. Structural studies on NP are reported with a view towards a new specific scoring function. PMID: 18790691
    28. Protein dynamics on the femtosecond to picosecond timescale are linked to enzymatic function. PMID: 18946041
    29. Comparative analysis of the model of BfPNP and the structure of HsPNP allowed identification of structural features responsible for differences in the computationally determined ligand affinities PMID: 19172318
    30. Results describe a tryptophan-free mutant of purine nucleoside phosphorylase and its dynamic activity. PMID: 19191546
    31. Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase PMID: 19425594

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Purine nucleoside phosphorylase deficiency (PNPD)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    PNP/MTAP phosphorylase family
  • 組織特異性:
    Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7892

    OMIM: 164050

    KEGG: hsa:4860

    STRING: 9606.ENSP00000354532

    UniGene: Hs.75514



主站蜘蛛池模板: 免费看国产成年无码av| 亚洲夜夜性无码| 漂亮人妻去按摩被按中出| 亚洲国产成人精品一区刚刚| 国产成人无码av在线播放不卡| 伊人99综合精品视频| 亚洲日韩一区精品射精| 隔壁人妻偷人bd中字| 亚洲在线国产日韩欧美| 果冻传媒mv免费播放在线观看| 亚洲伊人久久成人综合网| 天堂在线中文| 国产成人精品2021| 亚洲综合小说专区图片| 亚洲成av人片在www鸭子| 九九精品无码专区免费| 男阳茎进女阳道视频大全 | 国内自拍久久久久影院| 国产精品久久无码一区| 99精品国产兔费观看久久99| 毛片免费观看天天干天天爽| 亚洲精品中文字幕一区二区三区 | 国产精品一品二区三区的使用体验| 国产精品爆乳在线播放第一人称| 日本理论片午午伦夜理片2021| 国产又色又爽又黄的在线观看| 国产佗精品一区二区三区| 欧美国产成人精品一区二区三区| 中文 在线 日韩 亚洲 欧美| 激情av无码后入| 国色天香中文字幕在线视频| 欧美人与动牲交a欧美| 秋霞在线观看片无码免费不卡| 国产乱了伦视频大全亚琴影院| 无码人妻精品一区二区| 欧美黑人粗大xxxxbbbb| 日本少妇内射视频播放舔| 国产高清自产拍av在线| 久久国产精品免费一区二区三区| 亚洲狠狠色成人综合网| 久久综合九色综合欧洲98|