在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNN Antibody

  • 中文名稱:
    PNN兔多克隆抗體
  • 貨號:
    CSB-PA018276GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PNN
  • 別名:
    140 kDa nuclear and cell adhesion-related phosphoprotein antibody; Desmosome-associated protein antibody; Domain-rich serine protein antibody; DRS antibody; DRS protein antibody; DRSP antibody; Melanoma metastasis clone A protein antibody; MEMA antibody; Nuclear protein SDK3 antibody; Pinin antibody; PININ_HUMAN antibody; PNN antibody; SR like protein antibody; SR-like protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PNN
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
  • 基因功能參考文獻:
    1. Data suggest that SNRPA1, SNRPD1, and PNN are key players in the regulation of pluripotency-specific spliceosome assembly and the acquisition and maintenance of pluripotency. PMID: 28595116
    2. Pinin contributes to hepatocellular carcinoma progression and resistance to glucose deprivation-induced apoptosis via maintaining ERK1/2 activation PMID: 27175589
    3. Our findings suggested that PNN, as a valuable marker of prognosis, has important influence on the progression of colorectal cancer PMID: 27107420
    4. Pinin and CtBP are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells. PMID: 26871283
    5. These data suggest that lowering of PNN levels in epithelial cells results in dramatic transformation in the number and composition of splicing variants and that PNN plays a crucial role in the selection of which RNA isoforms differentiating cells produce. PMID: 26900324
    6. PNN has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium. PMID: 25489234
    7. ESRP1 and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics. PMID: 23299472
    8. Urinary desmosine level is an important biologoical marker, in patients treated with bilateral knee replacement and hydrocortison therapy. PMID: 23097096
    9. Pinin functions as a splicing regulator which participates itself directly in splicing reaction or indirectly via other components of splicing machinery PMID: 12051732
    10. Pnn may participate, via its interaction with RNPS1, in mRNA metabolism in the nucleus, including mRNA splicing and export PMID: 14517304
    11. the interaction of Pnn with the corepressor CtBP1 may modulate repression of E-cadherin transcription by CtBP1 PMID: 15542832
    12. Pnn may play a general role in the control of the cellular amount of family SR proteins through down-regulation of its own expression PMID: 16430868
    13. Corepressor CtBP and PNN/DRS differentially modulate transcription and splicing of the E-cadherin gene. PMID: 18086895

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
  • 蛋白家族:
    Pinin family
  • 組織特異性:
    Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primar
  • 數據庫鏈接:

    HGNC: 9162

    OMIM: 603154

    STRING: 9606.ENSP00000216832

    UniGene: Hs.409965



主站蜘蛛池模板: 天堂网在线www资源| 精品无码专区亚洲| 国产v在线最新观看视频| 玩两个丰满老熟女久久网| 中国女人高潮hd| 女人大荫蒂毛茸茸视频| 午夜精品久久久久久久久 | 国产精品人妻久久毛片| 精品日本免费一区二区三区| 免费又黄又爽又猛的毛片| 人妻少妇乱子伦精品无码专区电影| 亚洲aⅴ男人的天堂在线观看| 欧美性videos高清精品| 无遮挡呻吟娇喘视频免费播放| 中国人妻被两个老外三p | 亚洲成av人在线观看网站| 一道久久爱综合久久爱| 少妇邻居内射在线| 内射巨臀欧美在线视频| 日本久久综合久久鬼色| 亚洲精品乱码久久久久久按摩 | 97精品久久天干天天| 又色又爽又黄的视频女女| 欧美xxxx黑人又粗又长| 国产精品三级在线观看无码| 高清欧美性猛交xxxx黑人猛交| 亚洲精品久久久久久久观小说 | 久久精品无码免费不卡| 亚洲人成电影免费观看在线看| 综合亚洲桃色第一影院| 日韩人妻无码一区二区三区| 国产精品日日做人人爱| 中文字幕乱人伦高清视频| 欧美日韩国产中文高清视频| 日本va在线视频播放| 美女裸体无遮挡免费视频网站| 99久久精品无码一区二区毛片| 18禁无遮挡羞羞污污污污免费| 亚洲欧美黑人深喉猛交群| 精品国产乱码久久久久久1区2区| 亚洲2021av天堂手机版|