在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PNN Antibody

PNN Antibody

  • 中文名稱：
    PNN兔多克隆抗體
  • 貨號：
    CSB-PA018276GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PNN
  • 別名：
    140 kDa nuclear and cell adhesion-related phosphoprotein antibody; Desmosome-associated protein antibody; Domain-rich serine protein antibody; DRS antibody; DRS protein antibody; DRSP antibody; Melanoma metastasis clone A protein antibody; MEMA antibody; Nuclear protein SDK3 antibody; Pinin antibody; PININ_HUMAN antibody; PNN antibody; SR like protein antibody; SR-like protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PNN
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
  • 基因功能參考文獻：
    1. Data suggest that SNRPA1, SNRPD1, and PNN are key players in the regulation of pluripotency-specific spliceosome assembly and the acquisition and maintenance of pluripotency. PMID: 28595116
    2. Pinin contributes to hepatocellular carcinoma progression and resistance to glucose deprivation-induced apoptosis via maintaining ERK1/2 activation PMID: 27175589
    3. Our findings suggested that PNN, as a valuable marker of prognosis, has important influence on the progression of colorectal cancer PMID: 27107420
    4. Pinin and CtBP are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells. PMID: 26871283
    5. These data suggest that lowering of PNN levels in epithelial cells results in dramatic transformation in the number and composition of splicing variants and that PNN plays a crucial role in the selection of which RNA isoforms differentiating cells produce. PMID: 26900324
    6. PNN has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium. PMID: 25489234
    7. ESRP1 and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics. PMID: 23299472
    8. Urinary desmosine level is an important biologoical marker, in patients treated with bilateral knee replacement and hydrocortison therapy. PMID: 23097096
    9. Pinin functions as a splicing regulator which participates itself directly in splicing reaction or indirectly via other components of splicing machinery PMID: 12051732
    10. Pnn may participate, via its interaction with RNPS1, in mRNA metabolism in the nucleus, including mRNA splicing and export PMID: 14517304
    11. the interaction of Pnn with the corepressor CtBP1 may modulate repression of E-cadherin transcription by CtBP1 PMID: 15542832
    12. Pnn may play a general role in the control of the cellular amount of family SR proteins through down-regulation of its own expression PMID: 16430868
    13. Corepressor CtBP and PNN/DRS differentially modulate transcription and splicing of the E-cadherin gene. PMID: 18086895

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.
  • 蛋白家族：
    Pinin family
  • 組織特異性：
    Expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain and smooth and skeletal muscle. Expressed strongly in melanoma metastasis lesions and advanced primar
  • 數據庫鏈接：

    HGNC: 9162

    OMIM: 603154

    STRING: 9606.ENSP00000216832

    UniGene: Hs.409965



主站蜘蛛池模板： 亚洲国产精品久久久久久| 国产sm重味一区二区三区| 亚洲一区精品二人人爽久久| 欧美高清性色生活片免费观看 | 尤物国精品午夜福利视频| 国产成人精品久久一区二区| 亚洲综合激情七月婷婷| 啦啦啦www在线观看免费视频| 少妇下蹲露大唇无遮挡| 色综合久久久久综合99| 茄子在线看片免费人成视频| 国产高清在线精品一区下载| 欧美性猛交ⅹxxx乱大交妖精| 日韩人妻中文无码一区二区七区 | 欧美片内射欧美美美妇| 亚洲欧美综合精品二区| 亚洲人成无码网站| 香蕉久久久久久久av网站 | 天天做天天爱夜夜爽| 无码精品久久一区二区三区 | 国色天香成人一区二区| 中文天堂网www新版资源在线| 国产成人精品无码片区在线观看| 国产在线精品一区二区夜色| 国产精品欧美成人| 午夜成人鲁丝片午夜精品| 强奷乱码中文字幕熟女导航| 成 人色 网 站 欧美大片在线观看| 亚洲国产av无码一区二区三区 | 7777奇米四色成人眼影| 大又大粗又爽又黄少妇毛片| 国产精品1区2区3区在线观看| 丁香五月激情综合国产| 久爱无码免费视频在线| 亚洲爆乳大丰满无码专区| 2022久久国产精品免费热麻豆| 岛国在线无码高清视频| 久久丫精品系列| 一线二线三线天堂| 欧美日韩精品suv| 人妻熟妇乱又伦精品视频无广告 |