在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PNKD Antibody, FITC conjugated

  • 中文名稱:
    PNKD兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA843154LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PNKD Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PNKD
  • 別名:
    2210013N15Rik antibody; 2810403H05Rik antibody; AI854243 antibody; BRAIN PROTEIN 17 antibody; BRP17 antibody; DYT8 antibody; FKSG19 antibody; FPD1 antibody; KIAA1184 antibody; KIPP1184 antibody; MNCb-5687 antibody; MR-1 antibody; MR1 antibody; Myofibrillogenesis regulator 1 antibody; Paroxysmal nonkinesiogenic dyskinesia protein antibody; PDC antibody; PKND1 antibody; Pnkd antibody; PNKD_HUMAN antibody; Probable hydrolase PNKD antibody; TAHCCP2 antibody; Trans-activated by hepatitis C virus core protein 2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Probable hydrolase PNKD protein (78-243AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway.
  • 基因功能參考文獻:
    1. The short isoform of the myofibrillogenesis regulator 1 (MR-1S) as a new COX assembly factor, which works with the highly conserved PET100 and PET117 chaperones to assist COX biogenesis in higher eukaryotes. PMID: 28199844
    2. The combined analysis identified a new risk association for colorectal cancer (CRC) at 2q35 marked by rs992157 which is intronic to PNKD and TMBIM1.Intriguingly this susceptibility single-nucleotide polymorphism (SNP) is in strong linkage disequilibrium (r(2) = 0.90, D' = 0.96) with the previously discovered GWAS SNP rs2382817 for inflammatory bowel disease (IBD). PMID: 27005424
    3. study highlights the frequency, novel mutations and clinical and molecular spectrum of PRRT2, SLC2A1 and PNKD mutations as well as the phenotype-genotype overlap among these paroxysmal movement disorders. PMID: 26598494
    4. This study present the pedigree is the first PNKD family from Chinese Mainland, which is also the largest PNKD family among those reported across the globe. It included 5 generations and 26 patients. PMID: 25107857
    5. MR-1 functions as a tumor promoter in MCF7 cells by activating the MEK/ERK signaling PMID: 25066297
    6. MR-1 overexpression was tightly associated with more aggressive tumor behavior and a poor prognosis in pancreatic ductal adenocarcinoma. PMID: 23696030
    7. MR-1 was up-regulated in gastric cancer tissues. High expression of MR-1 in gastric cancer was significantly correlated with clinical stage. Postoperative survival of the MR-1 positive group tended to be poorer than that of the MR-1 negative group. PMID: 23082061
    8. A Taiwanese family with paroxysmal nonkinesigenic dyskinesia has a heterozygous c.20 C>T (p.Ala7Val) mutation which was clearly segregated in the five affected patients. PMID: 22967746
    9. MR-1S is highly expressed in ovarian cancer cells and tissues. PMID: 22780969
    10. In this report we present two families with paroxysmal non-kinesigenic dyskinesia of Southern European origin carrying a PNKD protein recurrent mutation. PMID: 21962874
    11. Mutations in PNKD causing paroxysmal dyskinesia alters protein cleavage and stability. PMID: 21487022
    12. The pnkd mutation alters such a response, suggesting that a less flexible AC region may be more effective in coupling Ca(2+) binding to channel opening. PMID: 20620873
    13. MR-1 is a novel myofibrillogenesis regulator in human muscle PMID: 15188056
    14. Different missense mutations in exon 1 of MR1 that cosegregate with PNKD were identified in each multiplex family. These single-nucleotide mutations predicted substitution of valine for alanine in residue 7 in one family and residue 9 in the other. PMID: 15824259
    15. autosomal dominant paroxysmal nonkinesigenic dyskinesia seems to be a homogenous disorder, for which the MR-1 gene is the major disease gene. PMID: 16632198
    16. The Serbian family further demonstrates that recurrent MR-1 mutations are associated with paroxysmal nonkinesigenic dyskinesia. PMID: 16972263
    17. Following down-regulation of MR-1, the phosphorylations of MLC2, focal adhesion kinase (FAK), and Akt were dramatically decreased PMID: 18948272
    18. Our family was 1 of 8 families originally reported in which a mutation in the myofibrillogenesis regulator 1 (MR-1) gene caused the paroxysmal non-kinesigenic dyskinesia phenotype PMID: 18948699

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Dystonia 8 (DYT8)
  • 亞細胞定位:
    [Isoform 1]: Membrane; Peripheral membrane protein.; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Mitochondrion.
  • 蛋白家族:
    Metallo-beta-lactamase superfamily, Glyoxalase II family
  • 組織特異性:
    Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only.
  • 數據庫鏈接:

    HGNC: 9153

    OMIM: 118800

    KEGG: hsa:25953

    STRING: 9606.ENSP00000273077

    UniGene: Hs.98475



主站蜘蛛池模板: 无码中文字幕色专区| 欧美性受xxxx狂喷水| 欧美国产一区二区三区激情无套| 国产三级久久久精品麻豆三级| 久久精品日日躁夜夜躁欧美| 无码人妻丝袜视频在线播免费 | 日韩免费无码专区精品观看| 欧美顶级少妇作爱| 人妻在客厅被c的呻吟| 日本午夜看x费免| 吃奶呻吟打开双腿做受视频| 夜夜躁日日躁狠狠久久av| 无码专区3d动漫精品免费| 国产亚洲精品福利视频在线观看| 欧美40老熟妇色xxxxx| 大地资源中文第三页| 成 人 在 线 免费观看| 久久天天躁夜夜躁狠狠综合| 久久精品第九区免费观看| 久久精品aⅴ无码中文字字幕重口| 国内精品伊人久久久久av| 亚洲国产av无码一区二区三区| 国产亚洲精品久久久久久老妇小说| 精品日本一区二区三区在线观看| 久久久久久亚洲精品成人| 护士av无码在线观看| 夜先锋av资源网站| 色综合久久久久综合体桃花网| 久久人妻国产精品| 337p日本欧洲亚洲大胆69影院| 国产亚洲精品久久久久久青梅| 精品久久久久久无码人妻蜜桃 | 狼色精品人妻在线视频免费| 爆乳一区二区三区无码| 欧美xxxxx精品| 欧美日韩精品一区二区视频| 国产亚洲tv在线观看| 国产精品乱码高清在线观看| 99这里只有精品| 久久国产精品99久久久久久口爆| 色99久久久久高潮综合影院|