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  4. PMPCB Antibody

PMPCB Antibody

  • 中文名稱：
    PMPCB兔多克隆抗體
  • 貨號：
    CSB-PA018243ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: PMPCB antibody at 2.3µg/ml + HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 55 kDa
      Observed band size: 55 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA018243ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PMPCB Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Beta MPP antibody; Beta-MPP antibody; BetaMPP antibody; Mitochondrial processing peptidase subunit beta antibody; Mitochondrial-processing peptidase subunit beta antibody; MPP11 antibody; MPPB antibody; MPPB_HUMAN antibody; MPPP52 antibody; P 52 antibody; P-52 antibody; P52 antibody; Peptidase mitichondrial processing beta antibody; PMPCB antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mitochondrial-processing peptidase subunit beta protein (110-380AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis.
  • 基因功能參考文獻：
    1. biallelic mutations in PMPCB cause defects in MPP proteolytic activity leading to dysregulation of iron-sulfur cluster biogenesis and triggering a complex neurological phenotype of neurodegeneration in early childhood. PMID: 29576218
    2. OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase. PMID: 24903103
    3. These results highlight a new role for MPP in PINK1 import and mitochondrial quality control via the PINK1-Parkin pathway. PMID: 22354088
    4. maintained expression and even up-regulation of some (PNPT1, PMPCB, HMMR/RHAMM, BSG and ERCC1) tumor associated antigens in CD40-activated leukemic cells. PMID: 19580345
  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Peptidase M16 family
  • 數據庫鏈接：

    HGNC: 9119

    OMIM: 603131

    KEGG: hsa:9512

    STRING: 9606.ENSP00000249269

    UniGene: Hs.184211



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