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  4. PLXNA2 Antibody

PLXNA2 Antibody

  • 中文名稱：
    PLXNA2兔多克隆抗體
  • 貨號：
    CSB-PA221959
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA221959(PLXNA2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA221959(PLXNA2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PLXNA2
  • 別名：
    Plexin-A2 antibody; PlexinA2 antibody; PLXA2 antibody; PLXA2_HUMAN antibody; PLXNA2 antibody; Semaphorin receptor OCT antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human PLXNA2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
  • 基因功能參考文獻：
    1. although plexin-A4 overexpression restored Sema3A signaling in plexin-A1-silenced cells, it failed to restore Sema3B signaling in plexin-A2-silenced cells. PMID: 25335892
    2. PLXNA2 upregulation contributes to TMPRSS2:ERG-mediated enhancements of PC3c cell migration and invasion. PMID: 23708657
    3. PLXNA2 has been identified as a new rare copy number variations gene for tetralogy of Fallot. PMID: 22912587
    4. results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 signaling PMID: 22095611
    5. PLXNA2 polymorphisms show association with ankylosing spondylitis. PMID: 22011406
    6. in vitro analysis of PLXNA2 revealed that the gene has higher expression in more aggressive breast cancer cell types. PMID: 21925246
    7. An association is identified between variants in the PLXNA2 gene and schizophrenia in two collections of schizophrenia cases and controls. High-density SNP mapping showed that the region of association spans approximately 60 kb of the PLXNA2 gene. PMID: 16402134
    8. results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample PMID: 17346868
    9. PLXNA2 confers a varying genetic risk for schizophrenia among different populations. PMID: 18065206
    10. Analysis of 3 SNPs at the PLXN A2 locus; we failed to replicate previously reported association of this locus and schizophrenia. PMID: 18096369
    11. mutations in GATA6 are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C-plexin A2 signaling PMID: 19666519

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Plexin family
  • 組織特異性：
    Detected in fetal brain.
  • 數據庫鏈接：

    HGNC: 9100

    OMIM: 601054

    KEGG: hsa:5362

    STRING: 9606.ENSP00000356000

    UniGene: Hs.497626



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