在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PLPP3 Antibody

PLPP3 Antibody

  • 中文名稱：
    PLPP3兔多克隆抗體
  • 貨號：
    CSB-PA018415LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA018415LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA018415LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PLPP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PLPP3; LPP3; PPAP2B; Phospholipid phosphatase 3; Lipid phosphate phosphohydrolase 3; PAP2-beta; Phosphatidate phosphohydrolase type 2b; Phosphatidic acid phosphatase 2b; PAP-2b; PAP2b; Vascular endothelial growth factor and type I collagen-inducible protein; VCIP
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Phospholipid phosphatase 3 protein (144-193AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PLPP3 Antibody (CSB-PA018415LA01HU)，的標記方式是Non-conjugated。對于PLPP3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA018415LB01HU PLPP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA018415LC01HU PLPP3 Antibody, FITC conjugated
    Biotin CSB-PA018415LD01HU PLPP3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines. By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function. Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers.; Independently of this phosphatase activity may also function in the Wnt signaling pathway and the stabilization of beta-catenin/CTNNB1, thereby regulating cell proliferation, migration and differentiation in angiogenesis or yet in tumor growth. Also plays a role in integrin-mediated cell-cell adhesion in angiogenesis.
  • 基因功能參考文獻：
    1. LPP3 is the key enzyme in the breakdown of LPA by melanoma cells. PMID: 28871044
    2. LPP3 is a negative regulator of inflammatory cytokines, leucocyte adhesion, cell survival, and migration in HAECs, suggesting a protective role of LPP3 against endothelial dysfunction. PMID: 27694435
    3. Data show gender-related differences in the association between phosphatidic acid phosphatase type 2B (PPAP2B) gene single nucleotide polymorphisms (SNPs) and coronary heart disease (CHD) susceptibility in the Chinese Han population. PMID: 28061459
    4. Mechanosensitive PPAP2B plays a critical role in promoting anti-inflammatory phenotype and maintaining vascular integrity of endothelial monolayer under atheroprotective flow. PMID: 26034042
    5. study concludes polymorphisms of TGM5, PPAP2B and PSMA4 are not major contributors tonon-small cell lung cancer susceptibility in never-smoking hinese population, this primarily can be attributed to the significantly distinct genetic background of Asian populations from western populations PMID: 24518713
    6. PPAP2B gene rearrangement is associated with lipomas. PMID: 23508853
    7. expression of LPP3 in human colon tumor (SW480) cells potentiated tumor growth via increased beta-catenin stability and CYCLIN-D1 synthesis PMID: 21569306
    8. Results identify a key role for LPP3 in orchestrating PTEN-mediated beta-catenin/LEF-1 signaling in EC migration, cell-cell adhesion, and formation of branching point structures. PMID: 20123964
    9. there are marked differences in biochemical activity between fly Wun and mammalian lipid phosphate phosphatase (LPPs), with Wun having a narrower activity range than has been reported for the mammalian LPPs PMID: 12856002
    10. LPP3 acted as an ecto-phosphatase on FTY720-P. PMID: 17555747

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein.
  • 蛋白家族：
    PA-phosphatase related phosphoesterase family
  • 組織特異性：
    Ubiquitously expressed. Highly expressed in heart and placenta.
  • 數據庫鏈接：

    HGNC: 9229

    OMIM: 607125

    KEGG: hsa:8613

    STRING: 9606.ENSP00000360296

    UniGene: Hs.405156



主站蜘蛛池模板： 久久激情五月丁香伊人| 亚洲另类激情综合偷自拍图片| 丁香五月开心婷婷激情综合| 国产亚洲香蕉线播放αv38| 亚洲色爱免费观看视频| 免费观看全黄做爰大片国产| 国产欠欠欠18一区二区| 国产免费一区二区三区免费视频| 午夜av亚洲一码二中文字幕青青| 大胸美女污污污www网站| 国产成人啪精品午夜网站a片免费 国产精品人妻久久久久 | 无遮挡激情视频国产在线观看| 俄罗斯少妇性xxxx另类| 一本一道久久a久久精品综合| 国产精品白浆一区二小说| 久久er热在这里只有精品66| 性av盈盈无码天堂| 最近日本免费观看高清视频| 久久国产精品99国产精| 狠狠久久噜噜熟女| 日本一卡2卡3卡4卡5卡精品视频 | 无码播放一区二区三区| 亚洲精品国产精品国自产| 国产在线一卡2卡三卡4卡免费| 亚洲中文字幕久久精品蜜桃| 美女露出粉嫩小奶头在视频18禁| 国产av熟女一区二区三区| 亚洲国产精品成人一区二区在线 | 欧美性猛交xxxxx按摩欧美| 欧美丰满老妇性猛交| 久久天天躁狠狠躁夜夜av| 久久av无码aⅴ高潮av喷吹| 天堂久久久久va久久久久| 久久av高清无码| 久久精品国产一区二区三区 | 蜜桃av久久久一区二区三区麻豆| 亚洲精品久久久久中文字幕一福利| 一区一区三区产品乱码| 富婆如狼似虎找黑人老外| 日日橹狠狠爱欧美视频| 99国精品午夜福利视频不卡|