在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PLEKHO1 Antibody

PLEKHO1 Antibody

  • 中文名稱：
    PLEKHO1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA105837
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA105837(PLEKHO1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PLEKHO1
  • 別名：
    C-Jun-binding protein antibody; Casein kinase 2-interacting protein 1 antibody; CK2 interacting protein 1 antibody; CK2 interacting protein 1 HQ0024c protein antibody; CK2-interacting protein 1 antibody; CKIP 1 antibody; CKIP-1 antibody; CKIP1 antibody; JBP antibody; OC120 antibody; Osteoclast maturation associated gene 120 protein antibody; Osteoclast maturation-associated gene 120 protein antibody; PH domain-containing family O member 1 antibody; PKHO1_HUMAN antibody; Pleckstrin homology domain containing family O member 1 antibody; Pleckstrin homology domain-containing family O member 1 antibody; PLEKHO1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human PLEKHO1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
  • 基因功能參考文獻(xiàn)：
    1. we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations. PMID: 28402261
    2. we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation. PMID: 28404913
    3. these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization. PMID: 28212865
    4. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging. PMID: 28083909
    5. High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis. PMID: 25966172
    6. New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL. PMID: 27840970
    7. There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 for neoplastic prostate cells transformation. PMID: 26160174
    8. CKIP-1 interacts with CARMA1 and has an inhibitory effect on PKCtheta;-CBM-NF-kappaB signaling. PMID: 24465689
    9. CKIP-1 controlled Smurf1 expression in colon cancer PMID: 23995790
    10. overexpression triggers classical monocyte activation and transactivation of the TNF promoter PMID: 23583459
    11. CKIP-1, through its leucine zipper, interacts with the Rpt6 and mediates the Smurf1-Rpt6 interaction. PMID: 23032291
    12. CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation--REVIEW PMID: 22878216
    13. The N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its subcellular localization and the nucleus-plasma membrane shuttling. PMID: 20171213
    14. examination of CK2alpha for a region that mediates interactions with CKIP-1 revealed a putative HIKE domain; this motif by itself may not be sufficient to mediate interactions. PMID: 15254037
    15. CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein. PMID: 15831458
    16. Data provide evidence that ATM, a predominantly nuclear kinase, could be relocalized to the plasma membrane by CKIP-1. PMID: 16325375
    17. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
    18. The results provide a novel role of CKIP-1 in cytokine signaling response and the biochemical mechanism, by which two previously identified modulators IFP35 and Nmi are involved via interactions. PMID: 17197158
    19. Results indicate that CKIP-1, a novel Akt PH domain-interacting protein, would be a candidate of tumor suppressor with an Akt inhibitory function. PMID: 17942896
    20. CKIP-1 is cleaved by caspase-3 during apoptosis. C-terminal fragments translocate to the cytoplasm and nucleus and inhibit AP-1 activity via direct interaction with c-Jun and JunD. CKIP-1 also forms a feedback with caspase-3 and enhances apoptosis. PMID: 15706351
    21. CKIP-1 could interact with ATM and recruits nuclear ATM proteins partially to the plasma membrane. The results provide the first evidence that ATM, a predominantly nuclear kinase, could be re-localized to the plasma membrane. PMID: 16325375

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm.
  • 組織特異性：
    Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 24310

    OMIM: 608335

    KEGG: hsa:51177

    STRING: 9606.ENSP00000358120

    UniGene: Hs.438824



主站蜘蛛池模板： 日日噜噜大屁股熟妇| 国产熟妇勾子乱视频| 亚洲国产欧美一区点击进入| 成年黄页网站大全免费无码| 久久99热久久99精品| 久久无码人妻精品一区二区三区| 免费无码av片在线观看动漫| 国产欧美日韩亚洲精品专区| 久久久国产精品黄毛片| 香蕉影院在线观看| 天堂aⅴ无码一区二区三区| 欧美老肥熟妇多毛xxxxx| 五十路熟女一区二区三区| 午夜成人亚洲理伦片在线观看| 337p人体 欧洲人体 亚洲| 国产肉丝袜在线观看| 亚洲美女又黄又爽在线观看| 久久精品欧美日韩精品| 亚洲人成77777在线播放网站| 涩欲国产一区二区三区四区| 特黄特色大片免费播放| 久久午夜夜伦鲁鲁片免费无码影视| 奇米777四色成人影视| 精品亚洲成a人无码成a在线观看| 中文字幕av无码不卡| 国产又黄又潮娇喘视频在线观看| 欧美精品人人做人人爱视频| 国产精品十八禁在线观看| 亚洲精品一区二区玖玖爱| 高潮好爽视频在线观看| 最新高清无码专区| 日韩精品乱码av一区二区| 亚洲国产一区二区精品无码| 377人体粉嫩噜噜噜| 真人做人试看60分钟免费| 亚洲中文字幕久久精品蜜桃| 无码国模国产在线观看| 起碰免费公开97在线视频| 人人妻一区二区三区| 欧美大胆作爱视频欣赏人体| 欧洲美女粗暴牲交免费观看|