在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PLD6 Antibody, Biotin conjugated

  • 中文名稱:
    PLD6兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA836649LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PLD6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PLD6
  • 別名:
    Choline phosphatase 6 antibody; Mitochondrial cardiolipin hydrolase antibody; Mitochondrial phospholipase antibody; MitoPLD antibody; Phosphatidylcholine hydrolyzing phospholipase D6 antibody; Phosphatidylcholine-hydrolyzing phospholipase D6 antibody; Phospholipase D family member 6 antibody; Phospholipase D6 antibody; PLD 6 antibody; pld6 antibody; PLD6_HUMAN antibody; Protein zucchini homolog antibody; ZUC antibody; Zucchini, Drosophila, homolog of antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Mitochondrial cardiolipin hydrolase protein (1-252AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger signaling lipid. Production of PA facilitates Mitofusin-mediated fusion, whereas the cleavage of PA by the Lipin family of phosphatases produces diacylgycerol (DAG) which promotes mitochondrial fission. Both Lipin and DAG regulate mitochondrial dynamics and membrane fusion/fission, important processes for adapting mitochondrial metabolism to changes in cell physiology. Mitochondrial fusion enables cells to cope with the increased nucleotide demand during DNA synthesis. Mitochondrial function and dynamics are closely associated with biological processes such as cell growth, proliferation, and differentiation. Mediator of MYC activity, promotes mitochondrial fusion and activates AMPK which in turn inhibits YAP/TAZ, thereby inducing cell growth and proliferation. The endonuclease activity plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. Implicated in spermatogenesis and sperm fertility in testicular germ cells, its single strand-specific nuclease activity is critical for the biogenesis/maturation of PIWI-interacting RNA (piRNA). MOV10L1 selectively binds to piRNA precursors and funnels them to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. Cleaves either DNA or RNA substrates with similar affinity, producing a 5' phosphate end, in this way it participates in the processing of primary piRNA transcripts. piRNAs provide essential protection against the activity of mobile genetic elements. piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation. PA may act as signaling molecule in the recognition/transport of the precursor RNAs of primary piRNAs. Interacts with tesmin in testes, suggesting a role in spermatogenesis via association with its interacting partner.
  • 基因功能參考文獻(xiàn):
    1. Propose that MIGA proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD. PMID: 26711011
    2. MitoPLD performs a critical function in a pathway that creates a specialized form of RNAi required by developing spermatocytes to suppress transposon mobilization during meiosis. PMID: 22281006
    3. Data suggest that mitochondrial-surface phosphatidic acid generated by MitoPLD/Zuc recruits or activates nuage components critical for piRNA production. PMID: 21397848
    4. PLD6, aka MitoPLD, encodes an N-terminal mitochondrial localization sequence, localizes to the outer mitochondrial surface, generates phosphatidic acid, a signaling lipid, and triggers trans-mitochondrial association; involved in mitochondrial fusion. PMID: 17028579
  • 亞細(xì)胞定位:
    Mitochondrion outer membrane; Single-pass membrane protein. Golgi apparatus.
  • 蛋白家族:
    Phospholipase D family, MitoPLD/Zucchini subfamily
  • 組織特異性:
    Predominantly expressed in testis and ovary, but not limited to gonads (at protein level). It is also found in brain, heart, pituitary gland, prostate, pancreas, thyroid, bone marrow, lung and muscle.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 30447

    OMIM: 614960

    KEGG: hsa:201164

    STRING: 9606.ENSP00000317177

    UniGene: Hs.729079



主站蜘蛛池模板: 欧洲国产伦久久久久久久| 乱妇乱女熟妇熟女网站| 成人国产精品一区二区网站公司 | 精品女同一区二区三区免费站| 亚洲欧美日韩中文无线码| 亚洲狠狠色成人综合网| 国产欧美二区综合| 亚洲性夜夜综合久久7777| 综合精品欧美日韩国产在线| 欧美 日韩 国产 另类 图片区| 国产在线精品一区在线观看| 国产成人无码a区精油按摩| 免费国精产品—品二品| 真人性生交免费视频| 性欧美俄罗斯极品| 亚洲线精品一区二区三八戒| 无码午夜福利片| 亚洲欧美国产精品久久| 天堂在线中文网www| 亚洲国产成人爱av在线播放| 国产亚洲日韩av在线播放不卡 | 久久丫精品忘忧草西安产品| 免费超爽大片黄| 国产偷伦视频片免费视频| 少妇被粗大的猛进出69影院| 性色欲情网站iwww九文堂| 久久久久久亚洲精品不卡| 亚洲性无码av在线欣赏网| 老湿机国产福利视频| 亚洲综合久久一本伊一区| 熟妇高潮喷沈阳45熟妇高潮喷| 夜夜爽妓女8888视频免费观看| 四虎影视国产精品久久| 久欠精品国国产99国产精2021| 8x国产精品视频| 未满小14洗澡无码视频网站| 337p日本欧洲亚洲大胆色噜噜| 日本人又黄又爽又色的视频| 真人啪啪高潮喷水呻吟无遮挡 | 国产真人作爱免费视频道歉| 亚洲欧美成人一区二区三区|