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  4. PLCL1 Antibody

PLCL1 Antibody

  • 中文名稱：
    PLCL1兔多克隆抗體
  • 貨號：
    CSB-PA624015LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA624015LA01HU diluted at 1:300 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA624015LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA624015LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PLCL1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PLCL1
  • 別名：
    Inactive phospholipase C-like protein 1 antibody; Inactive protein 1 antibody; Phospholipase C deleted in lung carcinoma antibody; Phospholipase C epsilon antibody; Phospholipase C like 1 antibody; Phospholipase C related but catalytically inactive protein antibody; Phospholipase C related, but catalytically inactive protein antibody; Phospholipase C-deleted in lung carcinoma antibody; Phospholipase C-related but catalytically inactive protein antibody; Phospholipase C-related catalytically antibody; PLC-L1 antibody; PLCE antibody; PLCL antibody; PLCL1 antibody; PLCL1_HUMAN antibody; PLDL1 antibody; PRIP antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Inactive phospholipase C-like protein 1 protein (1-108AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，PLCL1 Antibody (CSB-PA624015LA01HU)，的標記方式是Non-conjugated。對于PLCL1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA624015LB01HU PLCL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA624015LC01HU PLCL1 Antibody, FITC conjugated
    Biotin CSB-PA624015LD01HU PLCL1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
  • 基因功能參考文獻：
    1. susceptibility gene for dermatomyositis in Chinese patients with idiopathic inflammatory myopathies PMID: 26603167
    2. PRIP interacts with the catalytic subunits of PP1 and PP2A and the interactions are regulated by phosphorylation. [review] PMID: 23911386
    3. effect of DZP on PRIP-1 knockout mice was reduced PMID: 22128345
    4. In postmenopausal women, our results suggest that the PLCL1 rs7595412 polymorphism has no obvious effect on hip bone size and bone mineral density but may be associated with increased proportion of vertebral fracture and increased levels of osteocalcin PMID: 20030815
    5. PRIP-1 plays an important role in type A receptor signaling for gamma-aminobutyric acid in the brain PMID: 16952428
    6. PLCL1 is a novel gene associated with variation in hip bone size, which has a role in the pathogenesis of hip fractures PMID: 18776929

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  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.
  • 數據庫鏈接：

    HGNC: 9063

    OMIM: 600597

    KEGG: hsa:5334

    STRING: 9606.ENSP00000402861

    UniGene: Hs.153322



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