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  4. PLAA Antibody

PLAA Antibody

  • 中文名稱：
    PLAA兔多克隆抗體
  • 貨號：
    CSB-PA018107ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA018107ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA018107ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PLAA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ11281 antibody; FLJ12699 antibody; Glycerophosphatase antibody; OTTHUMP00000045176 antibody; Phospholipase A 2 activating protein antibody; Phospholipase A-2-activating protein antibody; Phospholipase A2 activating protein antibody; PLA2P antibody; Plaa antibody; PLAP antibody; PLAP_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Phospholipase A-2-activating protein (536-795AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
  • 基因功能參考文獻：
    1. In both human and mouse, hypomorphic mutations in the ubiquitin adaptor protein PLAA cause an infantile-lethal neurodysfunction syndrome with seizures. PMID: 28413018
    2. This study presented that Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. PMID: 28007986
    3. This review provides evidence that 1,25-dihydroxy vitamin D3 stimulates PLA2 via PLAA and CaMKII, a process initiated by Pdia3/PLAA interaction, which further triggers CaMKII-dependent PLA2 activation. [review] PMID: 25448737
    4. Function assignment to conserved residues in mammalian alkaline phosphatases. PMID: 11937510
    5. PLAP inhibits sPLA2-triggered release of fatty acids from erythrocyte membranes PMID: 14499668
    6. identified one stimulatory element, with Sp1 binding sites, and one inhibitory element, in exon 1 of the plaa gene PMID: 18291623
    7. Structural basis for ubiquitin recognition by a novel domain from the human phospholipase A2-activating protein PMID: 19423704

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  • 相關疾病：
    Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)
  • 亞細胞定位：
    Nucleus. Cytoplasm. Cell junction, synapse.
  • 蛋白家族：
    WD repeat PLAP family
  • 數據庫鏈接：

    HGNC: 9043

    OMIM: 603873

    KEGG: hsa:9373

    STRING: 9606.ENSP00000380460

    UniGene: Hs.27182



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