在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PLA2G1B Antibody

PLA2G1B Antibody

  • 中文名稱：
    PLA2G1B兔多克隆抗體
  • 貨號：
    CSB-PA018090ESR2HU
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PLA2G1B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Group IB phospholipase A2 antibody; Group IB secretory phospholipase A2 antibody; MGC119834 antibody; MGC119835 antibody; PA21B_HUMAN antibody; Phosphatidylcholine 2 acylhydrolase antibody; Phosphatidylcholine 2-acylhydrolase 1B antibody; Phospholipase A2 antibody; Phospholipase A2 group IB (pancreas) antibody; Phospholipase A2 group IB antibody; PLA 2 antibody; PLA2 antibody; PLA2A antibody; PLA2G1B antibody; PPLA 2 antibody; PPLA2 antibody; sPLA2IB antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Phospholipase A2 protein (23-148AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner. Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis. Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity.
  • 基因功能參考文獻：
    1. sPLA2-IB was correlated with the level of proteinuria in membranous nephropathy patients suggesting to be a potential biomarker for monitoring disease severity and therapeutic effects of both primary membranous nephropathy and secondary membranous nephropathy. PMID: 29649452
    2. The sPLA2 IB-PLA2R interaction stimulated podocyte apoptosis through activating ERK1/2 and cPLA2alpha and through increasing the podocyte AA content PMID: 25335547
    3. TNF-alpha-induced cPLA2 expression and PGE2 release were mediated through a Jak2/PDGFR/PI3K/Akt/p42/p44 MAPK/Elk-1 pathway in human lung epithelial cells. PMID: 24441870
    4. Exogenously added sPLA(2)-IB decreases phagocytosis of photoreceptor outer segments regardless of enzymatic activity. PMID: 22680611
    5. stimulation of three isoforms of PLA2 by thapsigargin liberates free AA that, in turn, induces capacitative calcium influx in human T-cells PMID: 12423354
    6. results indicate a selective sorting of a cell-derived cPLA2 during human cytomegalovirus maturation, which is further required for infectivity PMID: 15220446
    7. Group IB phospholipase A2 (PLA2G1B) stimulates leukotriene B4 (LTB4) production in the absence of cytochalasin B in human neutrophils. PMID: 16005851
    8. Here, we report sPLA2-IB in rat and human brain as well as in neurons in primary culture. The distribution of sPLA2-IB seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus. PMID: 16392040
    9. a critical regulatory role of arachidonate reacylation that limits leukotriene biosynthesis in concert with 5-lipoxygenase and cytosolic phospholipase A(2)alpha activation PMID: 16495221
    10. Results describe the structural basis for bile salt inhibition of pancreatic phospholipase A2. PMID: 17434532
    11. MMP-2/9 production is regulated by sPLA2-IB acting as a receptor ligand to activate cPLA2 PMID: 17981679
    12. pro-hG1B forms a trimer and PROP occupies the catalytic cavity and can be self-cleaved at 37 degrees C; A new membrane-bound surface and activation mechanism are proposed based on the trimeric model of pro-hG1B PMID: 19297324

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Note=Secreted from pancreatic acinar cells in its inactive form.
  • 蛋白家族：
    Phospholipase A2 family
  • 組織特異性：
    Selectively expressed in pancreas, lung, liver and kidney. Also detected at lower levels in ovary and testis.
  • 數據庫鏈接：

    HGNC: 9030

    OMIM: 172410

    KEGG: hsa:5319

    STRING: 9606.ENSP00000312286

    UniGene: Hs.992



主站蜘蛛池模板： 人妻熟女 视频二区 视频一区| 亚洲春色在线视频| 玩弄少妇人妻| 色婷婷综合久久久中文字幕| 一本之道高清无码视频| 久久se精品一区精品二区 | 狠狠躁天天躁无码中文字幕| 狠狠躁天天躁夜夜躁婷婷| 在线 | 一区二区三区| 熟睡中被义子侵犯在线播放| 国产成人片无码免费视频软件| 2020久热爱精品视频在线观看 | 精品无码综合一区二区三区| 国产精品aⅴ视频在线播放| 99久久精品国产第一页| 亚洲国产aⅴ成人精品无吗| 久青草国产97香蕉在线影院| 久久免费精品国产72精品九九| 在线精品视频一区二区三区| 天天天欲色欲色www免费| 8x福利精品第一导航| 亚洲国产欧美中文丝袜日韩| 国产精品午夜无码av体验区| 又粗又黄又硬又爽的免费视频| 亚洲日韩日本中文在线| 亚洲综合色88综合天堂| 久久精品国产99精品国产亚洲性色 | 国产成人a视频高清在线观看| 欧美乱码精品一区二区三区| 国产成人亚洲日韩欧美| √天堂资源在线中文8在线最新版| 人妻少妇精品中文字幕av | 女人被爽到高潮视频免费国产| 色噜噜狠狠狠狠色综合久| 国产农村乱对白刺激视频| 国产精品亚洲专区无码影院| 国产亚洲曝欧美曝妖精品| 亚洲欭美日韩颜射在线二| 亚洲一区二区三区香蕉| 天天爽亚洲中文字幕| 在线中文字幕亚洲日韩2020|