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  4. PLA2G1B Antibody

PLA2G1B Antibody

  • 中文名稱：
    PLA2G1B兔多克隆抗體
  • 貨號：
    CSB-PA018090ESR2HU
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PLA2G1B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Group IB phospholipase A2 antibody; Group IB secretory phospholipase A2 antibody; MGC119834 antibody; MGC119835 antibody; PA21B_HUMAN antibody; Phosphatidylcholine 2 acylhydrolase antibody; Phosphatidylcholine 2-acylhydrolase 1B antibody; Phospholipase A2 antibody; Phospholipase A2 group IB (pancreas) antibody; Phospholipase A2 group IB antibody; PLA 2 antibody; PLA2 antibody; PLA2A antibody; PLA2G1B antibody; PPLA 2 antibody; PPLA2 antibody; sPLA2IB antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Phospholipase A2 protein (23-148AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines. May act in an autocrine and paracrine manner. Upon binding to the PLA2R1 receptor can regulate podocyte survival and glomerular homeostasis. Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity.
  • 基因功能參考文獻：
    1. sPLA2-IB was correlated with the level of proteinuria in membranous nephropathy patients suggesting to be a potential biomarker for monitoring disease severity and therapeutic effects of both primary membranous nephropathy and secondary membranous nephropathy. PMID: 29649452
    2. The sPLA2 IB-PLA2R interaction stimulated podocyte apoptosis through activating ERK1/2 and cPLA2alpha and through increasing the podocyte AA content PMID: 25335547
    3. TNF-alpha-induced cPLA2 expression and PGE2 release were mediated through a Jak2/PDGFR/PI3K/Akt/p42/p44 MAPK/Elk-1 pathway in human lung epithelial cells. PMID: 24441870
    4. Exogenously added sPLA(2)-IB decreases phagocytosis of photoreceptor outer segments regardless of enzymatic activity. PMID: 22680611
    5. stimulation of three isoforms of PLA2 by thapsigargin liberates free AA that, in turn, induces capacitative calcium influx in human T-cells PMID: 12423354
    6. results indicate a selective sorting of a cell-derived cPLA2 during human cytomegalovirus maturation, which is further required for infectivity PMID: 15220446
    7. Group IB phospholipase A2 (PLA2G1B) stimulates leukotriene B4 (LTB4) production in the absence of cytochalasin B in human neutrophils. PMID: 16005851
    8. Here, we report sPLA2-IB in rat and human brain as well as in neurons in primary culture. The distribution of sPLA2-IB seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus. PMID: 16392040
    9. a critical regulatory role of arachidonate reacylation that limits leukotriene biosynthesis in concert with 5-lipoxygenase and cytosolic phospholipase A(2)alpha activation PMID: 16495221
    10. Results describe the structural basis for bile salt inhibition of pancreatic phospholipase A2. PMID: 17434532
    11. MMP-2/9 production is regulated by sPLA2-IB acting as a receptor ligand to activate cPLA2 PMID: 17981679
    12. pro-hG1B forms a trimer and PROP occupies the catalytic cavity and can be self-cleaved at 37 degrees C; A new membrane-bound surface and activation mechanism are proposed based on the trimeric model of pro-hG1B PMID: 19297324

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  • 亞細胞定位：
    Secreted. Note=Secreted from pancreatic acinar cells in its inactive form.
  • 蛋白家族：
    Phospholipase A2 family
  • 組織特異性：
    Selectively expressed in pancreas, lung, liver and kidney. Also detected at lower levels in ovary and testis.
  • 數據庫鏈接：

    HGNC: 9030

    OMIM: 172410

    KEGG: hsa:5319

    STRING: 9606.ENSP00000312286

    UniGene: Hs.992



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