在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PKP3 Antibody

  • 中文名稱:
    PKP3兔多克隆抗體
  • 貨號:
    CSB-PA018082GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    PKP 3 antibody; PKP3 antibody; PKP3_HUMAN antibody; Plakophilin 3b antibody; Plakophilin-3 antibody; Plakophilin3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PKP3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role in junctional plaques.
  • 基因功能參考文獻:
    1. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins. PMID: 29146182
    2. Children with low 25-hydroxyvitamin D and TMEM16J rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death. PMID: 26872154
    3. Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 participates in desmosome formation in absence of desmoglein 2 (DSG2). PMID: 25972099
    4. The results suggest that MMP7 over-expression may be one of the mechanisms by which PKP3 loss leads to increased cell invasion and tumor formation. PMID: 25875355
    5. reactive oxygen species (ROS) trigger the c-Src kinase-mediated tyrosine (Tyr)-195 phosphorylation of PKP3. PMID: 25501895
    6. These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1. PMID: 25208567
    7. cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression. PMID: 25225333
    8. Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3. PMID: 24328683
    9. The study describes a new protein variant of the human PKP3 gene, namely PKP3b, which differs from the published PKP3a only at the amino-terminus by the splicing in of the newly identified exon 1b. PMID: 24178805
    10. stratifin plays a role in regulating plakophilin-3 incorporation into the desmosomal plaque by forming a plakophilin-3 stratifin complex in the cytosol and thereby affecting desmosome dynamics in squamous epithelial cells. PMID: 24124604
    11. In breast cancer, compared with normal tissue, PKP1 and PKP2 expressions were indifferent (P > 0.05), but PKP3 expression was significantly increased PMID: 21947748
    12. Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis. PMID: 22701666
    13. These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts. PMID: 22223854
    14. plakoglobin and E-cadherin recruit plakophilin3 to the cell border to initiate desmosome formation PMID: 20859650
    15. loss of PKP3 expression during gastric adenocarcinoma progression may indicate an invasive phenotype. PMID: 21194493
    16. both loss of PKP1 and up-regulation of PKP3 expression are biologically important events in prostate cancer and are associated with a more aggressive phenotype PMID: 20348237
    17. PKP3 mRNA can be used as a marker of subclinical disease in gastrointestinal cancer and thus holds potential clinical relevance as a predictor for disease outcome PMID: 20501752
    18. PKP3, whose desmosomal expression and protein interactions are broader than those of PKP1 and -2, is a unique multiprotein binding element in many epithelial desmosomes. PMID: 12707304
    19. Cytoplasmic PKP3 is constitutively associated with RNA-binding proteins and indicate an involvement in processes of translation and RNA metabolism. PMID: 16407409
    20. The transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition. PMID: 17391671
    21. plakophilin3 loss leads to a decrease in cell-cell adhesion leading to the stimulation of neoplastic progression and metastasis PMID: 18729189

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.
  • 蛋白家族:
    Beta-catenin family
  • 組織特異性:
    Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing t
  • 數據庫鏈接:

    HGNC: 9025

    OMIM: 605561

    KEGG: hsa:11187

    STRING: 9606.ENSP00000331678

    UniGene: Hs.534395



主站蜘蛛池模板: 亚洲熟妇av乱码在线观看| 久久99精品久久久久婷婷暖| 日本不卡一区二区三区在线| 9re热国产这里只有精品| 久久久久久人妻毛片a片| 国产午夜不卡片免费视频| 成人一区二区免费视频| 亚洲春色在线视频| 日本高清在线一区二区三区| 国产精品久久久久久久久岛| 亚洲国产欧美在线人成人| 97se亚洲国产综合自在线| 无码加勒比一区二区三区四区| 少妇的肉体在线观看| 狼色精品人妻在线视频| 狠狠色噜噜狼狼狼色综合久| 精品系列无码一区二区三区| 九九久久精品国产免费看小说 | 亚洲欧美日韩国产综合点击进入| 中文国产成人精品久久久| 国产成人国产在线观看| 热re99久久精品国99热| 无码一区二区三区中文字幕| 亚洲曰本av在线天堂| 亚洲一区精品无码色成人| 国产精品久久欧美久久一区| 国产v亚洲v天堂a无码| 又黄又爽又色的视频| 无码东京热一区二区三区| 动漫精品视频一区二区三区| 粗大的内捧猛烈进出在线视频| 女人高潮流白浆视频| 午夜福利麻豆国产精品| 一区一区三区产品乱码亚洲| 欧美日韩国产精品| 日韩av激情在线观看| 国产高潮抽搐喷水高清| 欧美肥臀大屁股magnet| 国产后入又长又硬| b站永久免费看片大全| 大学生被内谢粉嫩无套|