在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PKD2L1 Antibody

PKD2L1 Antibody

  • 中文名稱：
    PKD2L1兔多克隆抗體
  • 貨號：
    CSB-PA214505
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA214505(PKD2L1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PKD2L1
  • 別名：
    B830002B15 antibody; BC046386 antibody; PCL antibody; PK2L1 antibody; PK2L1_HUMAN antibody; PKD2L antibody; PKD2L1 antibody; PKDL antibody; Polycystic kidney disease 2 like 1 antibody; Polycystic kidney disease 2 like 1 protein antibody; Polycystic kidney disease 2-like 1 protein antibody; Polycystin L antibody; Polycystin-2 homolog antibody; Polycystin-2L1 antibody; Polycystin-L antibody; Polycystin-L1 antibody; Transient receptor potential cation channel subfamily P member 3 antibody; TRPP3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human PKD2L1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration. The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription. Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells. The heteromeric channel formed by PKD1L2 and PKD1L3 is activated by low pH, but opens only when the extracellular pH rises again. May play a role in the perception of carbonation taste. May play a role in the sensory perception of water, via a mechanism that activates the channel in response to dilution of salivary bicarbonate and changes in salivary pH.
  • 基因功能參考文獻：
    1. The pore helix and transmembrane segment 6 of PKD2L1 are involved in upper and lower-gate opening, adopt an open conformation. PMID: 29567962
    2. PKD2 and PKD1 genes are mutated in autosomal dominant polycystic kidney disease. PKD2 can form either a homomeric cation channel or a heteromeric complex with the PKD1 receptor, presumed to respond to ligand(s) and/or mechanical stimuli. Here, we identify a two-residue hydrophobic gate in PKD2L1, and a single-residue hydrophobic gate in PKD2. PMID: 29899465
    3. palmitoylation at Cys-38 and phosphorylation at Thr-39 independently regulated TRPP3 channel function PMID: 27754867
    4. our study identified C1 as the first PKD2L1 domain essential for both PKD2L1 trimerization and channel function, and suggest that PKD2L1 and PKD2L1/PKD1L3 channels share the PKD2L1 trimerization process. PMID: 25820328
    5. Trimerization may be important for both homo- and possibly heteromeric assemblies of PKD2L1. PMID: 22193359
    6. This study demonistrated that human PKD2L play the role of food preference behavior. PMID: 22794107
    7. Pkd2L1 is a novel target channel whose function is regulated by the versatile scaffolding protein RACK1. PMID: 22174419
    8. Despite the moderate sequence identity between C-terminal regulatory domains (CRDs) of PKD2 and PKD2L1, they both form trimers, implying that trimeric organization of CRDs may be true of all polycystin channels. PMID: 20408813
    9. the PKD2L1-PKD1L3 complex is involved in acid sensing in vivo PMID: 20406802
    10. The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. PMID: 11959145
    11. Taken together, alpha-actinin not only attaches TRPP3 to the cytoskeleton but also up-regulates TRPP3 channel function. PMID: 17944866

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle.
  • 蛋白家族：
    Polycystin family
  • 組織特異性：
    Detected in taste bud cells in fungiform papillae (at protein level). Ubiquitous. Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. Isoform 4 appears to be expressed only in transformed lymphoblasts.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9011

    OMIM: 604532

    KEGG: hsa:9033

    STRING: 9606.ENSP00000325296

    UniGene: Hs.159241



主站蜘蛛池模板： 亚洲乱码一卡二卡卡3卡4卡 | 国产色婷婷五月精品综合在线| 欧洲精品欧美精品| 国内精品乱码卡一卡2卡麻豆| 亚洲嫩模喷白浆在线观看| 国产福利视频在线观看 | 欧美精品中文字幕在线视| 国产精品久久欧美久久一区| 少女韩国电视剧在线观看完整| 成人亚洲欧美在线观看| 色欲天天天天天综合网| 乱精品一区字幕二区| 最近2019中文字幕大全第二页| 国产精品色情国产三级在| 亚洲精品无码精品mv在线观看 | 亚洲欧洲自拍拍偷午夜色| 久久亚洲精品无码播放| 成人污污污www网站免费| 久久无码高潮喷水| 女人与拘性猛交视频| 狠狠精品久久久无码中文字幕 | 少妇厨房愉情理9仑片视频| 日韩av片无码一区二区三区| 国产啪精品视频网站免费尤物| 亚洲综合天堂av网站在线观看| 亚洲第一网站男人都懂| 国产与黑人在线播放| 夜夜高潮夜夜爽夜夜爱爱| 亚洲成a人片77777kkkk| 人妻中文字幕无码系列| 玩弄人妻少妇老师美妇厨房| 青青久在线视频免费观看| 国产av人人夜夜澡人人爽 | 超清av在线播放不卡无码| 亚洲欧洲av无码专区| 人人爽人人澡人人人妻、百度| 人妻饥渴偷公乱中文字幕| 亚洲精品一区国产| 乱子伦国产对白在线播放| 国产精品99精品久久免费| 狠狠亚洲婷婷综合色香五月排名|