在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PITX3 Antibody

  • 中文名稱:
    PITX3兔多克隆抗體
  • 貨號:
    CSB-PA685328
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA685328(PITX3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain cancer tissue using CSB-PA685328(PITX3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 231 cell, mouse brain tissue and A549 cell, Primary antibody: CSB-PA685328(PITX3 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PITX3
  • 別名:
    Homeobox protein PITX 3 antibody; Homeobox protein PITX3 antibody; MGC12766 antibody; Paired like homeodomain transcription factor 3 antibody; Paired-like homeodomain transcription factor 3 antibody; Pituitary homeobox 3 antibody; PITX 3 antibody; Pitx3 antibody; PITX3_HUMAN antibody; PTX 3 antibody; PTX3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human PITX3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle.
  • 基因功能參考文獻:
    1. Results show that a common polymorphism in the PITX3 gene affects the risk of developing Parkinson's disease (PD) dementia and visuospatial dysfunction in idiopathic PD. If validated, these findings can provide new insights into the neurobiology and genetics of non-motor symptoms in PD. PMID: 28991698
    2. Study showed that PITX3 methylation was significantly methylated in head and neck squamous cell carcinoma (HNSCC) tumor compared to normal adjacent tissue and correlated with lymph node status. These results provide evidence that PITX3 DNA methylation is an independent prognostic biomarker for overall survival in patients with HNSCC and might aid in the process of risk stratification for individualized treatment. PMID: 28174607
    3. These findings suggest that p.A203fs in PITX3 is the cause of cataracts in the recruited family. PMID: 28249924
    4. PITX3 variants rs3758549 and rs4919621 are not associated with ET in Chinese Han population. PMID: 27145793
    5. novel PITX3 mutation c.573del, p.(Ser192Alafs*117), was identified in heterozygous state in a Belgo-Romanian family with a similar phenotype PMID: 24555714
    6. Meta-analysis suggests that rs3758549, rs2281983, and rs4919621 single nucleotide polymorphisms are not major determinants of the risk for Parkinson's disease PMID: 24525476
    7. the SNP rs3758549 might contribute to the occurrence of Parkinson disease (PD) in the Asian population, especially early onset PD in the Asian population. PMID: 24394914
    8. Meta-analysis and HuGE review of genotype prevalence and gene-disease association. (HuGE Navigator) PMID: 11994226
    9. Mutations in PITX3 are not a common cause or a risk factor for multisystem atrophy and progressive supranuclear palsy in the Polish population. PMID: 23694789
    10. Presence of the rs4919621 allele A in PITX3 significantly increases the risk of Parkinson's disease (PD) patients in a Caucasian population, while rs2281983 allele C and rs4919621 allele A were both risk factors in early onset PD. PMID: 22429667
    11. novel synonymous SNP in PITX3 gene may contribute to PD risk in the Chinese population. PMID: 22411443
    12. Deletion of PITX3 is associated with aggressive neurobehavioral phenotype in Smith-Magenis Syndrome. PMID: 22223473
    13. Data show that BFSP2 and PITX3, hitherto known to cause eye defects only in a dominant fashion, can also present recessively. PMID: 21836522
    14. The results of this study suggested that these PITX3 SNPs do not contribute to the risk of developing PD in EOPD or LOPD in Chinese. PMID: 22037506
    15. The single nucleotide polymorphism rs3758549 (C >T substitution) in the Pitx3 gene is a potential risk for sporadic Parkinson disease (PD), especially early-onset PD in Chinese Han population. PMID: 21138504
    16. This study found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early-onset Parkinson's disease and familial Parkinson's disease. PMID: 21469209
    17. Allele & genotype frequencies did not differ between patients & controls for rs2281983, rs4919621, & rs3758549. These SNP sites do not contribute to the risk of developing PD in late-onset sporadic PD in this Chinese population. PMID: 21565251
    18. The 542delC is a novel mutation in PITX3 causing an isolated posterior polar cataract. PMID: 21633712
    19. This study suggested that the PITX3 gene rs3758549 polymorphism may increase the susceptibility of Parkinson's disease in chinese. PMID: 21524731
    20. PITX3 may play a role in the pathogenesis of Parkinson disease. PMID: 19394114
    21. The result of this study found a strong association between the PITX3 promoter rs3758549 polymorphism and Parkinson's disease. PMID: 19345444
    22. Genetic variation in PITX3 may increase the risk of developing schizophrenia. PMID: 20570600
    23. The A-allele of a HapMap tagging SNP (rs4919621) that was genotyped in a population of Parkinson's disease (PD) patients, was significantly more common in PD patients with an early age of onset. PMID: 18420308
    24. The absence of PITX3 mutations in a family presenting congenital cataract and mental retardation, is reported. PMID: 20376326
    25. A family with posterior polar cataract with a novel deletion mutation in PITX3. PMID: 15286169
    26. we mapped dominant congenital posterior polar cataracts to chromosome 10q24. On sequencing the coding region of PITX3, we found a 17-base-pair duplication in exon 4. PMID: 16272057
    27. This is the first report of homozygous PITX3 mutations in humans. The phenotype in these individuals highlights the role of PITX3 in ocular and central nervous system (CNS) development. PMID: 16565358
    28. The 657ins17bp duplication of the PITX3 gene is the cause of the cataract phenotype in the large pedigree. PMID: 16636655
    29. we discuss the role of Pitx3 in molecular mechanisms involved in the regional specification, neuronal specification and differentiation of mDA neurons--REVIEW PMID: 17017509
    30. The G219fs mutation was found in multiple families affected with congenital cataracts along with anterior segment malformations. The S13N mutant showed only minor alteration and may represent a rare polymorphism in the PITX3 gene. PMID: 17888164
    31. We provide evidence for a novel, strong and reproducible association of the PITX3 promoter SNP rs3758549: C>T (p=0.004) with Parkinson Disease. PMID: 17905480
    32. Duplication of a segment of PITX3 can result in severe symptoms leading to functional blindness while in other individuals in the same family or in other families, the same duplication leads to treatable cataract with minimal visual impairment. PMID: 18989383

    顯示更多

    收起更多

  • 相關疾病:
    Anterior segment dysgenesis 1 (ASGD1); Cataract 11, multiple types (CTRCT11)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Paired homeobox family, Bicoid subfamily
  • 組織特異性:
    Highly expressed in developing eye lens.
  • 數據庫鏈接:

    HGNC: 9006

    OMIM: 107250

    KEGG: hsa:5309

    STRING: 9606.ENSP00000359019

    UniGene: Hs.137568



主站蜘蛛池模板: 欧洲一卡2卡3卡4卡乱码视频 | 国产无遮挡a片无码免费| 欧美3p两根一起进高清免费视频| 久久国产精品无码hdav| 国产精品久久久久久免费软件| 国产萌白酱喷水视频在线播放| 产后漂亮奶水人妻无码| 亚洲线精品一区二区三区影音先锋 | 国产欧美日韩综合精品二区 | 亚洲欧美国产精品专区久久| 少妇粉嫩小泬喷水视频| 免费观看啪啪黄的网站| 综合精品欧美日韩国产在线| 国产乱子伦一区二区三区=| 日日摸日日碰人妻无码| 人人妻人人澡人人爽国产一区| 久久亚洲精品国产精品婷婷| 欧美伊人色综合久久天天| 亚洲精品高清无码视频| 成人网站免费大全日韩国产| 高清av熟女一区| 天天综合色天天综合色hd| 成人试看120秒体验区| 日本大片免a费观看视频三区| 婷婷丁香五月六月综合激情啪| 69久久精品无码一区二区无码 | 香港经典a毛片免费观看hd| 国产成+人+综合+亚洲欧美| 中文字幕一区在线观看视频| 人妻久久久一区二区三区| 欧洲美熟女乱又伦免费视频| 爆乳喷奶水无码正在播放| 插b内射18免费视频| 国产无遮挡无码视频免费软件| 免费国产在线一区二区| 日本老熟妇乱子伦视频| 久久久久麻豆v国产精华液好用吗| 精品乱码一区二区三四区视频| 国产日产精品久久快鸭的功能介绍| 国产男生夜间福利免费网站| 国产熟妇按摩3p高潮大叫|