在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PIR Antibody

  • 中文名稱:
    PIR兔多克隆抗體
  • 貨號:
    CSB-PA018032GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PIR
  • 別名:
    3-dioxygenase PIR antibody; Iron binding nuclear protein antibody; Pir antibody; PIR_HUMAN antibody; Pirin antibody; Probable quercetin 2 antibody; probable quercetin 2,3-dioxygenase PIR antibody; Probable quercetinase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human PIR
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
  • 基因功能參考文獻:
    1. Data suggest that only the Fe(III) form of pirin [not the Fe(II) form] enhances affinity of binding between p65 and DNA in the pirin-p65-DNA supramolecular complex. (pirin = quercetin 2,3-dioxygenase; p65 = RELA proto-oncogene NF-kappaB subunit) PMID: 28825294
    2. Pirin regulates E-cadherin independently of Bcl3-Slug signaling. PMID: 25680527
    3. The NRF2 transcription factor binds to this element in vivo and drives the basal PIR expression. PMID: 24390086
    4. Pirin is a newly identified binding partner of EAF2/U19 capable of down-regulating EAF2/U19 protein and alleviating its inhibition of prostate cancer cell survival/proliferation. PMID: 24272884
    5. Data indicate that the R-shaped area composes the interface for pirin-NF-kappaB binding that is responsible for modulation of NF-kappaB's DNA-binding properties. PMID: 23716661
    6. pirin may have a relevant role in melanoma progression. PMID: 21514450
    7. knockdown of pirin or treatment with the small molecule inhibited melanoma cell migration PMID: 20711196
    8. This study aimed to examine genetic variations in the PIR gene by a comprehensive tagging method and its sex-specific effects on bone mineral density and osteoporotic risk. PMID: 19766747
    9. An abnormal pattern of PIR sub-cellular localization is a characteristic feature of a subset of melanomas, and suggest it may represent a marker associated with disease progression. PMID: 20089166
    10. Pirin downregulation is a feature of acute myeloid leukemia and leads to impairment of terminal myeloid differentiation. PMID: 20010624
    11. x-ray crystallography of of human pirin shows that it is an iron-binding nuclear protein and transcription cofactor PMID: 14573596
    12. First report of enzymatic activity for any member of the Pirin family which may be an important connection to their roles in transcriptional regulation. PMID: 15951572

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    Pirin family
  • 組織特異性:
    Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
  • 數據庫鏈接:

    HGNC: 30048

    OMIM: 300931

    KEGG: hsa:8544

    STRING: 9606.ENSP00000369785

    UniGene: Hs.495728



主站蜘蛛池模板: 一区二区伊人久久大杳蕉| 国产免费午夜a无码v视频| 人妻无码中文字幕免费视频蜜桃 | 国产清纯美女爆白浆视频| 亚洲熟妇无码乱子av电影| 亚洲欧美综合在线天堂| 亚洲中文字幕a∨在线| 永久免费的啪啪网站免费观看| 在线播放国产一区二区三区 | 欧美最猛性xxxxx大叫| 女人被黑人躁得好爽视频| 国产成人精品视频一区二区不卡| 热久久视久久精品18| 日韩 高清 无码 人妻| 亚洲一卡2卡三卡4卡国色天香| 狠狠cao2020高清视频| 亚州少妇无套内射激情视频| 欧美日韩国产精品自在自线| 狠狠躁天天躁夜夜躁婷婷| 亚洲人成网站在小说| 鲁鲁网亚洲站内射污| 国产乱子伦精品免费视频| 狠狠色噜噜狠狠狠狠色综合久av| 日本丰满妇人成熟免费中文字幕| 99久久综合狠狠综合久久止| 国产美女牲交视频| 国产美女牲交视频| 欧美激情a∨在线视频播放| 中文字字幕在线成人av电影| 少妇人妻偷人精品无码视频新浪| 无码精品一区二区三区免费视频| 综合久久—本道中文字幕| 白嫩无码人妻丰满熟妇啪啪区百度| 中文字幕一区二区三区精华液 | 久久精品噜噜噜成人av| 久久久无码精品亚洲日韩按摩| а天堂中文在线官网在线| 粉嫩大学生无套内射无码卡视频| 天堂网www天堂资源网| 国内精品乱码卡一卡2卡麻豆| 天天做天天欢摸夜夜摸狠狠摸|