在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PIM3 Antibody

  • 中文名稱:
    PIM3兔多克隆抗體
  • 貨號:
    CSB-PA968784
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA968784(PIM3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA968784(PIM3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse skeletal muscle tissue, Primary antibody: CSB-PA968784(PIM3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PIM3
  • 別名:
    Kid 1 antibody; Kid1 antibody; Kinase induced by depolarization antibody; ONCOGENE PIM3 antibody; PIM 3 antibody; Pim 3 oncogene antibody; Pim-3 proto-oncogene; serine/threonine kinase antibody; PIM3 antibody; Pim3 oncogene antibody; PIM3_HUMAN antibody; Protein kinase Kid 1 antibody; Protein kinase Kid1 antibody; Serine/threonine kinase Pim 3 antibody; Serine/threonine kinase Pim3 antibody; Serine/threonine protein kinase Pim 3 antibody; Serine/threonine protein kinase Pim3 antibody; Serine/threonine-protein kinase Pim-3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human PIM3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
  • 基因功能參考文獻:
    1. show that PIM1 contributes to melanoma cell proliferation and tumor growth in vivo; however, the presence of PIM2 and PIM3 could also influence the outcome. PMID: 27448973
    2. These results demonstrate the involvement of PIM kinases in LIF-induced regulation in different trophoblastic cell lines which may indicate similar functions in primary cells. PMID: 28729093
    3. PIM kinases in classical Hodgkin lymphoma exhibit pleiotropic effects, orchestrating tumor immune escape and supporting Reed-Sternberg cell survival. PMID: 28698206
    4. Our study suggests that up-regulation of Pim-3 successfully accelerated Chronic Obstructive Pulmonary Disease development, and aggravated lung damage PMID: 28214201
    5. High PIM3 expression is associated with osteosarcoma. PMID: 27826617
    6. The expression status of Pim-3 mRNA was significantly associated with pathological parameters such as pre-surgery prostate specific antigen, Gleason score, pathological stage, and lymphoid metastasis. PMID: 27826135
    7. Pim-3 expression was inversely correlated with that of miR-377. PMID: 27638830
    8. SSRP1/Ets-1/Pim-3 signalling is tightly associated with the proliferation, apoptosis, autophagy, invasion and clonogenicity of nasopharyngeal carcinoma cells, and blockage of this signalling facilitates chemosensitivity of the cells to docetaxel. PMID: 27525970
    9. Pim-3 expression showed a positive correlation with tumor cell differentiation. PMID: 26768612
    10. Pim-3 has a role in human pancreatic cancer cell survival against radiation PMID: 27016481
    11. A high percentage of urothelial carcinomas express Pim kinases. Pim expression differs in NILG, NIHG, and IHG lesions. PMID: 26551340
    12. MicroRNA506 participates in pancreatic cancer pathogenesis by targeting PIM3 PMID: 26238203
    13. Pim-3 kinase enhances growth and metastatic properties of prostate cancer xenografts. PC-3 prostate cancer cells overexpressing either Pim-1 or Pim-3 kinases form larger xenograft tumors than the parental PC-3 cells. PMID: 26075720
    14. Knockdown of Pim-3 by specific shRNA slowed decreased proliferation, induced cell cycle arrest in the G0/G1 phase, and increased apoptosis in glioblastoma cells. PMID: 25817345
    15. PIM3 expression is higher in ovarian cancer than in normal ovarian tissue. Upregulation of PIM3 promotes proliferation and migration of ovarian cancer cells. PMID: 25921139
    16. Data demonstrate the role of PIM kinases in driving myeloid leukemia, and as candidate molecules for therapy against human malignancies. PMID: 25238262
    17. we constructed a dual-function small hairpin RNA (shRNA) vector containing an shRNA targeting Pim-3 and a TLR7-stimulating ssRNA. PMID: 24723452
    18. Blocking the activities of PIM kinases(PIM1, PIM2 and PIM3) could prevent pancreatic cancer development. PIM kinases(PIM1, PIM2 and PIM3) may be a novel target for cancer therapy PMID: 24799066
    19. cancer development and in promoting tumor neovascularization and subsequent tumor growth. Targeting Pim-3 may play a dual role in halting tumor progression, by promoting tumor cell death and blocking angiogenesis PMID: 24789328
    20. Our study indicates that the expression of Pim kinases is physiologically related to DNA-PKcs and ATM in ECs. PMID: 22282239
    21. observations indicate that TCTP enhances Pim-3 stability to simultaneously promote and prevent cell-cycle progression and apoptosis, respectively PMID: 24165482
    22. the existence of different patterns of expression of Pim-3, c-Myc, and p-p27 and their clinicopathologic correlations in adenocarcinomas of the gastric cardia and the distal stomach. PMID: 24488669
    23. Pim-1 and Pim-3 play overlapping but non-identical roles as it relates to gemcitabine sensitivity of pancreatic cancer cells and Pim-3 is upregulated in pancreatic ductal carcinoma. PMID: 23760491
    24. Pim-3 can promote pancreatic tumor growth and angiogenesis by stimulating the VEGF pathway. PMID: 23845873
    25. PIM kinases promote the production of IFNgamma, the hallmark cytokine produced by Th1 cells. PMID: 23209281
    26. Pim protein kinase-3 is regulated by TNF-alpha and promotes endothelial cell sprouting. PMID: 21870113
    27. Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas. PMID: 21646687
    28. Ginsenoside Rg3 decreased both Pim-3 and pBad expressions in a dose-dependent manner in PANC-1 cells. PMID: 19624871
    29. A cell-based test system useful for rapid and inexpensive pre-screening of compounds capable of preventing Pim-mediated phosphorylation is discussed. PMID: 20939820
    30. Pim-3 has an important role in modulating c-Myc and PGC-1alpha protein levels and cell growth PMID: 21187426
    31. Pim-3 alone cannot cause, but can accelerate HCC development. PMID: 20101231
    32. Aberrnntly expressed Pim-3 can cause autonomous cell proliferation or prevent apoptosis in hepatoma cell lines. PMID: 15540201
    33. Pim kinases promote cell cycle progression and tumorigenesis by down-regulating p27(Kip1) expression at both transcriptional and posttranslational levels. PMID: 18593906
    34. Ets-1 can induce aberrant Pim-3 expression and subsequently prevent apoptosis in human pancreatic cancer cells. PMID: 19154409
    35. expression of Pim-1 & Pim-3 is induced in response reactivation in KSHV-infected cells; they are required for KSHV reactivation under these conditions; data indicate Pim-1 & Pim-3 contribute to viral reactivation by phosphorylating the KSHV LANA PMID: 19266083

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PIM subfamily
  • 組織特異性:
    Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small int
  • 數據庫鏈接:

    HGNC: 19310

    OMIM: 610580

    KEGG: hsa:415116

    STRING: 9606.ENSP00000353824

    UniGene: Hs.530381



主站蜘蛛池模板: 人人插人人插人人爽| 18禁无遮挡肉动漫在线播放观看| 国产成人精品日本亚洲999| 久久精品无码一区二区三区免费 | 精品乱码一区内射人妻无码| 老妇高潮潮喷到猛进猛出| 婷婷久久综合九色综合绿巨人| 日韩人妻无码精品久久| 无人去码一码二码三码区| 亚洲熟妇丰满多毛xxxx| 无码国产精品一区二区免费式芒果| 高潮内射免费看片| 国产精品69人妻无码久久| 最新亚洲中文av在线不卡| 97精品国产手机| 少妇挑战三个黑人惨叫4p国语| 尤物yw午夜国产精品大臿蕉| 18禁无遮挡无码国产免费网站| 国语自产精品视频在线看| 精品欧美乱码久久久久久1区2区 | 亚洲动漫精品无码av天堂| 日韩欧美亚洲综合久久影院ds| 男人女人做爽爽18禁网站| 欧美肥妇bwbwbwbxx| 亚洲精品第一国产综合亚av| 国产亚洲精品久久久久9999| 午夜伦费影视在线观看| 国产三级av在线播放| 中文字幕人妻少妇引诱隔壁| 免费三级现频在线观看播放| 中文无码一区二区三区在线观看 | 五十老熟妇乱子伦免费观看| 国产精品尹人在线观看| 性暴力欧美猛交在线播放| 色婷婷综合中文久久一本| 久久久亚洲精品无码| 日产2021免费一区| 337p日本欧洲亚洲大胆张筱雨| 少妇粉嫩小泬喷水视频| 人妻熟女av一区二区三区| 国产一卡二卡四卡无卡免费|