在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PILRA Antibody, FITC conjugated

  • 中文名稱:
    PILRA兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA892331LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PILRA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PILRA
  • 別名:
    Cell surface receptor FDF03 antibody; FDF03 antibody; Inhibitory receptor PILR-alpha antibody; paired immunoglobulin-like receptor alpha antibody; Paired immunoglobulin-like type 2 receptor alpha antibody; PILRA antibody; PILRA_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Paired immunoglobulin-like type 2 receptor alpha protein (22-226AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP.; (Microbial infection) Acts as an entry co-receptor for herpes simplex virus 1.
  • 基因功能參考文獻:
    1. Data suggest that, although PILRA exhibits essentially the same recognition of different glycopeptides, slight modifications of linker sugar cause significant changes in a wide area of the binding interface, resulting in a reduction of binding affinity; analogs/fragments of gpb were used in these studies. (PILRA = paired immunoglobin like type 2 receptor alpha; gpb = envelope glycoprotein B, Herpes simplex virus type 1) PMID: 29046357
    2. The interaction of NK cells with PILRalpha expressing targets lead to elevated IFNgamma secretion and cytotoxicity. In conclusion, PILRalpha is a novel NK activating ligand which binds and activates an unknown NK receptor expressed on a unique NK cell subset. PMID: 27029068
    3. Transcriptome wide association study results identified two novel genes as statistically significantly associated with nonobstructive azoospermia susceptibility: PILRA and ZNF676. PMID: 29202958
    4. PILRalpha exhibits large conformational change to recognize simultaneously both the sTn O-glycan and the compact peptide structure constrained by proline residues PMID: 24889612
    5. These results contribute our knowledge of the biological functions of HBVDNAPTP1 and provide novel data to aid in the further analysis of the regulatory mechanism of this protein. PMID: 24253495
    6. We demonstrated that three residues (Y2, R95, and W108) presented on the surface of PILRalpha form the sialic acid binding site equivalent to those in siglecs but are arranged in a unique linear mode. PMID: 24843130
    7. The amino terminus of herpes simplex virus 1 gK is functionally and physically associated with the gB-PILRalpha protein complex and regulates membrane fusion of the viral envelope with cellular membranes during virus entry. PMID: 23302878
    8. The authors show that the human ocular and highly neurovirulent HSV-1 strain McKrae enters substantially more efficiently into cells via the gB-specific human paired immunoglobulin-like type-2 receptor-alpha (hPILR-alpha). PMID: 22695228
    9. Data show that PILRalpha/ligand interactions require conserved PILRalpha arginine (Arg)-133 (mouse) and Arg-126 (human). PMID: 22396535
    10. These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha. PMID: 21241660
    11. PILRalpha protein was successfully crystallized at 293 K using the sitting-drop vapour-diffusion method and the crystals diffracted to 1.3 A resolution. PMID: 18097101
    12. The results demonstrate that cellular receptors for both gB and gD are required for HSV-1 infection and that PILRalpha plays an important role in HSV-1 infection as a coreceptor that associates with gB. PMID: 18358807
    13. viral entry via PILRalpha appears to be conserved but that there is a PILRalpha preference among alphaherpesviruses PMID: 19244335
    14. Insertional mutations of gB reduced cell fusion activity when PILRalpha was overexpressed much more than nectin-1. PMID: 19457990

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Secreted.
  • 組織特異性:
    Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expr
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20396

    OMIM: 605341

    KEGG: hsa:29992

    STRING: 9606.ENSP00000198536

    UniGene: Hs.444407



主站蜘蛛池模板: 国产欧美综合一区二区三区| 在教室伦流澡到高潮hgl视频| 欧美肉大捧一进一出免费视频| 久久久老熟女一区二区三区| 亚洲精品无码久久毛片| 久久中文精品无码中文字幕下载| 色偷偷偷在线视频播放| 国产成人精品综合在线观看| 野外少妇被弄到喷水在线观看| 又色又爽又黄的美女裸体网站| 亚洲一区二区三区四区五区六区| 99这里只有精品| 亚洲性夜夜综合久久7777| 午夜精品影视国产一区在线麻豆| 国产女人18毛片水真多| 少妇愉情理伦片高潮日本| 欧美 亚洲 国产 制服 中文 | 高潮潮喷奶水飞溅视频无码| 国产av一区二区三区最新精品| 亚洲国产午夜精品理论片在线播放| 国产精品一国产精品一k频道| 自拍偷自拍亚洲精品第1页| 一本大道久久久久精品嫩草| 国产无遮挡a片无码免费| 无码三级av电影在线观看| 超薄丝袜足j好爽在线| 免费萌白酱国产一区二区三区| 少妇人妻上班偷人精品视频| 在线播放国产麻豆va剧情| 鲁大师在线视频播放免费观看| 人妻无码中文字幕| 亚洲亚洲人成综合丝袜图片 | 九九久久精品国产波多野结衣| 丝袜 中出 制服 人妻 美腿| 精品一卡二卡三卡| 免费做a爰片久久毛片a片下载| 欧美性受xxxx狂喷水| 在线精品一区二区三区| 亚洲乱色伦图片区小说| 亚洲精品成人网站在线观看| 国产剧情国产精品一区|