在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PIK3R2 Antibody, FITC conjugated

  • 中文名稱:
    PIK3R2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA018005LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PIK3R2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    p85 antibody; p85 beta antibody; P85B antibody; P85B_HUMAN antibody; Phosphatidylinositol 3 kinase antibody; Phosphatidylinositol 3 kinase regulatory beta subunit antibody; Phosphatidylinositol 3 kinase regulatory subunit beta antibody; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 antibody; Phosphatidylinositol 3 kinase; regulatory subunit; polypeptide 2 (p85 beta) antibody; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta antibody; Phosphatidylinositol 3-kinase regulatory subunit beta antibody; Phosphoinositide 3 kinase regulatory subunit 2 (beta) antibody; Phosphoinositide 3 kinase regulatory subunit 2 antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta) antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 2 antibody; Phosphoinositide 3 kinase; regulatory subunit 2 (beta) antibody; Phosphoinositide 3 kinase; regulatory subunit 2 (p85 beta) antibody; PI3 kinase p85 beta subunit antibody; PI3 kinase p85 subunit beta antibody; PI3-kinase regulatory subunit beta antibody; PI3-kinase subunit p85-beta antibody; PI3K antibody; PI3K regulatory subunit beta antibody; PIK3R 2 antibody; PIK3R2 antibody; PtdIns 3 kinase p85 beta antibody; PtdIns-3-kinase regulatory subunit beta antibody; PtdIns-3-kinase regulatory subunit p85-beta antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit beta protein (75-125AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.
  • 基因功能參考文獻:
    1. Data indicate that miR-126 overexpression in RASFs inhibits PIK3R2 expression and promotes proliferation while inhibiting apoptosis. PMID: 27729613
    2. this study shows that targeted depletion of PIK3R2 induces regression of lung squamous cell carcinoma PMID: 27835880
    3. Data show that phosphoinositol-3 kinase regulatory subunit 2 (PIK3R2) mRNA is a direct target of miR-126-3p. PMID: 27191494
    4. Data indicate that miR-126 expression negatively correlates with p85beta in CLL patients and that miR-126 can effectively target p85beta in a cell-line system. PMID: 28299881
    5. Mosaic mutations in PIK3CA or PIK3R2 which activate class 1A PI3K cause severe non-ketotic hypoglycaemia in a subset of patients, with the metabolic phenotype presumably related to the extent of mosaicism within the liver PMID: 28566443
    6. PIK3R2 D557H mutation causes polymicrogyria, corpus callosum hyperplasia and focal cortical dysplasia. PMID: 26860062
    7. miR-3151 silencing by DNA methylation protected chronic lymphocytic leukemia cells from apoptosis by over-expression of its direct targets MADD and PIK3R2, constitutive activation of MEK/ERK and PI3K/AKT signaling , and over-expression of MCL1. PMID: 26517243
    8. pik3r2 was confirmed to be a direct target of miR126 in prostate cancer. PMID: 26677064
    9. indicated that miR-126 expression was negatively correlated with PIK3R2 mRNA expression PMID: 26723864
    10. The miR-126 was found to act as proliferation suppressor targeting PIK3R2 gene and reducing p85beta (a regulatory subunit of PI3K kinase) protein translation and lower AKT kinase activity. PMID: 26384552
    11. Constitutional and mosaic mutations in the PIK3R2 gene are associated with developmental brain disorders ranging from Bilateral perisylvian polymicrogyria with a normal head size to the megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. PMID: 26520804
    12. The authors show that this potentiation involves reorganization of the natural CrkL-p85beta complex into a novel trimeric complex where influenza A virus NS1 serves as a bridging factor. PMID: 26099693
    13. the metastasis and angiogenesis functions of miR-126-3p were mediated by LRP6 and PIK3R2. PMID: 25240815
    14. Study indicates that miR-126 is a tumor suppressor that inhibits gastric cancer cells proliferation by targeting PI3KR2, Crk and PLK2. PMID: 24969300
    15. FBXL2 mediates the ubiquitylation and degradation of p85beta on cell membranes. PMID: 23604317
    16. miR-126-mediated phosphoinositide-3-kinase regulation, not only fine-tunes VEGF-signaling, but it strongly enhances the activities of Ang-1 on vessel stabilization and maturation. PMID: 22867989
    17. p85beta phosphoinositide 3-kinase subunit regulates tumor progression PMID: 22733740
    18. recombinant production, crystallization and X-ray structure determination at 2.0 A resolution of the SH3 domain of human p85beta is described PMID: 22102226
    19. miR-126 could target both VEGFA and PIK3R2, and its expression was decreased in human breast cancer, implying that miR-126 may play a role in tumor genesis and growth by regulating the VEGF/PI3K/AKT signaling pathway PMID: 21249429
    20. The crystal structure of human p85beta iSH2 determined to 3.3A resolution is reported. PMID: 21139197
    21. Macropinocytosis is regulated by interactions between Abi1 pY213 and the C-terminal SH2 domain of p85-thereby linking Abl kinase signaling to p85-dependent regulation of macropinocytosis. PMID: 20598684
    22. Overexpression of SH3 domain of p85beta inhibits influenza A virus replication. PMID: 20653952
    23. the PTEN phosphatase is active against the PI3K p85beta subunit and dephosphorylates a protein involved in insulin signaling where known downstream consequences are increased cell migration, motility, and invasion. PMID: 20515662
    24. oncogenic p85 mutations lead to a loss of a C2-iSH2 domain contact that is required for inhibition of p110alpha by p85. PMID: 19915146
    25. NS5A mediates activation of beta-catenin in a phosphoinositide-3 kinase-dependent fashion. PMID: 19846673
    26. Mutant viruses carrying NS1 with mutations in SH3 binding motif 1 failed to interact with p85ss and induce the subsequent activation of PI3K/Akt pathway. PMID: 17881440
    27. in VSMCs exposed to hyperglycemia, IGF-I stimulation of Shc facilitates the transfer of Grb2 to p85 resulting in enhanced PI3K activation and AKT phosphorylation leading to enhanced cell proliferation and migration PMID: 18420583

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1 (MPPH1)
  • 蛋白家族:
    PI3K p85 subunit family
  • 數據庫鏈接:

    HGNC: 8980

    OMIM: 603157

    KEGG: hsa:5296

    STRING: 9606.ENSP00000471914

    UniGene: Hs.371344



主站蜘蛛池模板: 成人三级无码视频在线观看| 亚洲电影天堂av2017| 成人爽a毛片免费看| 无码一区二区免费波多野播放搜索| 无码人妻一区二区三区免费手机| 在线天堂中文在线资源网| 国产亚洲精品久久久美女18黄| 中文字幕亂倫免賛視頻| 精品人妻无码一区二区三区蜜桃一 | 波多野结衣50连登视频| 一区二区无码免费视频网站| 人妻出差精油按摩被中出| 精品久久久久久久中文字幕| 使劲快高潮了国语对白在线| 在线观看免费视频污网站| 天天av天天av天天透| 日本中文字幕乱码免费| 中国国语毛片免费观看视频| 国产欧美在线观看不卡| 午夜裸体性播放| 日本妇人成熟免费中文字幕| 人妻无码中字在线a| 久久久久亚洲精品无码网址| 欧洲性久久精品| 久久国产免费福利永久| 无码精品黑人一区二区三区| 精品亚洲成a人片在线观看少妇| 国产亚洲精品久久yy5099| 成人亚洲精品777777| 中文无码伦av中文字幕| 少妇无码av无码专区线| 亚洲婷婷五月激情综合app| gv天堂gv无码男同在线观看| 欧美日韩国产精品自在自线| 水蜜桃精品一二三| 四虎成人精品永久网站| 日本丰满少妇裸体自慰| 久久九九精品国产综合喷水| av性色av久久无码ai换脸| 情侣黄网站免费看| 亚洲国产精品日韩av不卡在线|