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PIGO Antibody, FITC conjugated

  • 中文名稱：
    PIGO兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA855068LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PIGO Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PIGO antibody; UNQ632/PRO1249 antibody; GPI ethanolamine phosphate transferase 3 antibody; EC 2.-.-.- antibody; Phosphatidylinositol-glycan biosynthesis class O protein antibody; PIG-O antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GPI ethanolamine phosphate transferase 3 protein (219-420AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond.
  • 基因功能參考文獻：
    1. PIGO deficiency shows variable phenotypes from infantile lethality to mild learning difficulties PMID: 28337824
    2. Disease associated PIGO missense mutations resulted in decreased activity in vitro. PMID: 28327575
    3. Novel PIGO mutations expand the clinical spectrum of PIGO abnormalities to include epileptic encephalopathy with mild elevation of alkaline phosphatase (ALP). PMID: 24417746
    4. Our data identify PIGO as the second gene associated with HPMRS and suggest that a deficiency in GPI-anchor synthesis is the underlying molecular pathomechanism of HPMRS. PMID: 22683086
  • 相關疾病：
    Hyperphosphatasia with mental retardation syndrome 2 (HPMRS2)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    PIGG/PIGN/PIGO family, PIGO subfamily
  • 數據庫鏈接：

    HGNC: 23215

    OMIM: 614730

    KEGG: hsa:84720

    STRING: 9606.ENSP00000339382

    UniGene: Hs.522099



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