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  4. PIF1 Antibody, Biotin conjugated

PIF1 Antibody, Biotin conjugated

  • 中文名稱：
    PIF1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA863987LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PIF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PIF1
  • 別名：
    ATP dependent DNA helicase PIF1 antibody; ATP-dependent DNA helicase PIF1 antibody; C15orf20 antibody; DNA helicase homolog PIF1 antibody; DNA helicase PIF1 antibody; DNA repair and recombination helicase PIF1 antibody; Petite integration frequency 1 antibody; PIF antibody; PIF1 5' to 3' DNA helicase antibody; PIF1 5' to 3' DNA helicase homolog antibody; PIF1 antibody; PIF1 DNA helicase antibody; PIF1/RRM3 DNA helicase like protein antibody; PIF1/RRM3 DNA helicase-like protein antibody; PIF1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ATP-dependent DNA helicase PIF1 protein (125-360AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.
  • 基因功能參考文獻：
    1. Structural and functional characterization of the unwinding mechanism of Bacteroides and human Pif1 helicases has been reported. PMID: 26904952
    2. Authors characterised a functional role for human PIF1 in DNA replication that becomes important for cell growth under oncogenic stress. PMID: 25359767
    3. Pif1 readily unfolds a parallel quadruplex DNA substrate in a multiturnover reaction and also generates some product under single cycle conditions PMID: 25589786
    4. A minimum of 10 oligonucleotide bases are required for PIF1 binding and the hydrolysis of ATP. PMID: 23924759
    5. the yeast ortholog of Pif1 appears to move along DNA in single nucleotide or base pair steps, powered by hydrolysis of 1 molecule of ATP. PMID: 23596008
    6. Evidence that the PIF1 N-terminal (PINT) domain as crucial functions in PIF1 helicase. PMID: 18835853
    7. when expressed in yeast, human PIF1 suppressed both G-quadruplex-associated DNA damage and telomere lengthening PMID: 23657261
    8. PIF1 variant L319P was identified in three breast cancer families PMID: 22347400
    9. Findings suggest roles for PIF1 in S-phase entry and progression that are essential to protect human tumor cells from apoptosis. PMID: 21616935
    10. Human Pif1 could have a role in processing G4 structures that arise in the single-stranded nucleic acid intermediates formed during DNA replication and gene expression. PMID: 20524933
    11. hPif1 may regulate telomere elongation by decreasing telomerase processivity, possibly via a mechanism that involves the unwinding of telomerase RNA from telomeric DNA by hPif1. PMID: 16522649
    12. Human PIF, like S. cerevisiae Pif1p, plays a role in telomerase regulation. PMID: 17172855
    13. hPif1 in the nucleus may be involved in chromosome maintenance in association with DNA replication PMID: 17827721
    14. hPif1 specifically recognizes and unwinds DNA structures resembling putative stalled replication forks. PMID: 19700773

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  • 亞細胞定位：
    Nucleus.; [Isoform 4]: Mitochondrion.
  • 蛋白家族：
    Helicase family, PIF1 subfamily
  • 組織特異性：
    Weak ubiquitous expression.
  • 數據庫鏈接：

    HGNC: 26220

    OMIM: 610953

    KEGG: hsa:80119

    STRING: 9606.ENSP00000268043

    UniGene: Hs.112160



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