在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PI4K2B Antibody

PI4K2B Antibody

  • 中文名稱(chēng)：
    PI4K2B兔多克隆抗體
  • 貨號(hào)：
    CSB-PA017954GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    2610042N09Rik antibody; 4933409G22Rik antibody; FLJ11105 antibody; P4K2B_HUMAN antibody; Phosphatidylinositol 4 kinase type 2 beta antibody; Phosphatidylinositol 4 kinase type II beta antibody; Phosphatidylinositol 4-kinase type 2-beta antibody; Phosphatidylinositol 4-kinase type II-beta antibody; PI4K 2 beta antibody; PI4K 2b antibody; PI4K II beta antibody; PI4K IIb antibody; Pi4k2b antibody; PI4KII-BETA antibody; PI4KIIb antibody; PIK42B antibody; Type II phosphatidylinositol 4 kinase beta isoform antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PI4K2B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
  • 基因功能參考文獻(xiàn)：
    1. RNA interference of the type II phosphatidylinositol 4-kinases PI4KIIa and PI4KIIa in primary human endothelial cells leads to formation of an increased proportion of short WPB with perturbed packing of VWF, as exemplified by increased exposure of antibody-binding sites. PMID: 27068535
    2. Here two crystal structures are presented: the structure of human PIK42A and the structure of PIK42B containing a nucleoside analogue. PMID: 26143926
    3. Results provide evidence that type II PtdIns 4-kinase b was indeed recruited to CD4- p56lck complex upon CD4 receptor cross linking, suggests a mechanism for its association and a role for it in CD4-mediated intracellular calcium release. PMID: 24972704
    4. Canonical tyrosine residues mutation in FcepsilonRIgamma ITAM (Y65 and Y76) reveals that these two tyrosine residues in gamma subunit are required for its interaction with type II PtdIns 4-kinases. PMID: 24481753
    5. type II PtdIns 4-kinase beta is a key component in early T cell activation signaling cascades PMID: 23619705
    6. PIP4Kbeta interacts with and modulates nuclear localization of the PIP4Kalpha. PMID: 20583997
    7. There is no evidence to suggest that PI4K2B is contributing to bipolar disorder in this family but a role for this gene in schizophrenia has not been excluded. PMID: 19539307
    8. Type II PtdIns 4-kinase beta interacts with TCR-CD3 zeta chain. The C-terminal ITAM is critical for enzyme docking on the zeta chain. The association is tyrosyl phosphorylation dependent. Mutation of Y-151 & Y-142 disrupts interaction of the 2 proteins. PMID: 16337488
    9. UV irradiation increases nuclear PtdIns5P levels via inhibition of the activity of the beta isoform of PtdIns5P 4-kinase (PIP4Kbeta), an enzyme that can phosphorylate and remove PtdIns5P. PMID: 16949365
    10. LB-PI4K2B-1S-specific CD4(+) T cells contributed to the antitumor response by both directly eliminating malignant cells as effector cells and stimulating CD8(+) T cell immunity as helper cells. PMID: 18316730

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Membrane. Note=Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism.
  • 蛋白家族：
    PI3/PI4-kinase family, Type II PI4K subfamily
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18215

    OMIM: 612101

    KEGG: hsa:55300

    STRING: 9606.ENSP00000264864

    UniGene: Hs.191701



主站蜘蛛池模板： 真人与拘做受免费视频一| 激情人妻另类人妻伦| 亚洲综合天堂av网站在线观看| 人妻色综合网站| 欧美激情一区二区三区高清视频| 女同性av片在线观看免费网站| 国内精品久久久久影视老司机| 久久精品国产久精国产果冻传媒| 亚洲日韩国产中文其他| 婷婷综合缴情亚洲狠狠小说| 日日噜噜噜噜夜夜爽亚洲精品| 少妇性l交大片| 三级成年网站在线观看级爱网| 成人网站精品久久久久| 九色porny丨自拍视频| www国产精品内射熟女| 亚洲偷自拍国综合| 久久er99国产精品免费| 野花社区www视频最新资源| 国产日韩欧美一区二区东京热| 免费人妻av无码专区| 久久aⅴ无码av高潮av喷吹| 亚洲精品国产综合久久一线| 亚洲成av 人片在线观看无码| 久久99精品国产麻豆不卡| 久久亚洲一区二区三区四区| 日本黄页网站免费观看| 亚洲精品色播一区二区| 欧美视频网站www色| 国产又大又硬又粗| 国色天香成人网| 男男女女爽爽爽免费视频| 久久99精品久久久久久久不卡| 乌克兰少妇xxxx做受野外| 午夜福利视频| 亚洲精品无码av人在线观看| 熟女人妻高清一区二区三区 | 国产伦精品一区二区三区免.费| 精品无码一区二区三区| 欧美高清性色生活片免费观看 | 开心色怡人综合网站|