在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PI4K2A Antibody

PI4K2A Antibody

  • 中文名稱：
    PI4K2A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA017953GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    PI4K2A antibody; Phosphatidylinositol 4-kinase type 2-alpha antibody; EC 2.7.1.67 antibody; Phosphatidylinositol 4-kinase type II-alpha antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PI4K2A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
  • 基因功能參考文獻(xiàn)：
    1. PI-273 is the first substrate-competitive, subtype-specific inhibitor of PI4KIIalpha, the use of which will facilitate evaluations of PI4KIIalpha as a cancer therapeutic target. PMID: 28827373
    2. Mining oncogenomic databases revealed that loss of the PI4K2B allele and underexpression of PI4KIIbeta mRNA are associated with human cancers. This finding supports the cell data and suggests that PI4KIIbeta may be a clinically significant suppressor of invasion. PMID: 27798239
    3. PtdIns4KIIalpha regulates receptor sorting at early endosomes through a PtdIns(4)P-dependent pathway and contributes substrate for the synthesis of endosomal PtdIns(4,5)P2. PMID: 26823017
    4. PI4KIIalpha is a specific downstream effector of GABARAP and it generates PI4P, which has a key role in the final stage of autophagy. PMID: 26038556
    5. phosphatidylinositol 4-kinase IIalpha knockdown inhibited vesicle-associated membrane protein 3 trafficking to perinuclear membranes and impaired the rate of VAMP3-mediated recycling of the transferrin receptor PMID: 25002402
    6. structure and phylogenetic analysis PMID: 24752359
    7. PI4K2A is a novel regulator of vesicular trafficking and neurotransmission in the brain. PMID: 25083612
    8. The palmitoylation insertion contributes to the phosphatidylinositol-binding pocket and anchors PI4KIIalpha to the membrane. PMID: 24675427
    9. The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton. PMID: 23676666
    10. Knockdown of PI4KIIalpha inhibits EGF-stimulated Akt phosphorylation. PMID: 21218173
    11. Results suggest that the phosphatidylinositol 4-kinase 2-alpha gene may not be a cause of autosomal recessive hereditary spastic paraplegia in humans. PMID: 21190509
    12. PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PMID: 20154717
    13. Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover. PMID: 12594831
    14. The active site of this enzyme occurs in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum PMID: 12650639
    15. propose that PI4KIIalpha establishes the Golgi's unique lipid-defined organelle identity by generating PI(4)P-rich domains that specify the docking of the AP-1 coat machinery PMID: 12914695
    16. The linkage of CD63 with PI 4-kinase type II may result in the recruitment of this signaling enzyme to specific membrane locations in the platelet where it influences phosphoinositide-dependent signaling and platelet spreading. PMID: 15711748
    17. changes in membrane environment can regulate PI4KIIalpha activity. PMID: 16249177
    18. phosphatidylinositol 4-kinase IIalpha is necessary for the correct endocytic traffic and downregulation of activated epidermal growth factor receptor. PMID: 16443754
    19. both the kinase activity and the sorting signal present in PI4KIIalpha are necessary to rescue endosomal PI4KIIalpha siRNA-induced mutant phenotypes PMID: 18256276
    20. AP-3 and BLOC-1 act, either in concert or sequentially, to specify sorting of PI4KIIalpha along the endocytic route. PMID: 19010779
    21. Dvl directly interacted with and activated PI4KII alpha by increasing its V(max) for ATP and PtdIns. In addition, Dvl regulated PI4KII alpha and PIP5KI via different domains. PMID: 19561074

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Golgi apparatus, trans-Golgi network membrane; Lipid-anchor. Membrane raft. Cell projection, dendrite. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, synaptosome. Mitochondrion. Endosome. Cytoplasmic vesicle. Membrane; Lipid-anchor. Cell membrane. Perikaryon. Cell projection, neuron projection.
  • 蛋白家族：
    PI3/PI4-kinase family, Type II PI4K subfamily
  • 組織特異性：
    Widely expressed. Highest expression is observed in kidney, brain, heart, skeletal muscle, and placenta and lowest expression is observed in colon, thymus, and small intestine.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 30031

    OMIM: 609763

    KEGG: hsa:55361

    STRING: 9606.ENSP00000359665

    UniGene: Hs.25300



主站蜘蛛池模板： 久久久久久午夜成人影院| 成人免费无码视频在线网站 | 日本精品αv中文字幕| 亚洲综合无码一区二区痴汉| 亚欧av无码乱码在线观看性色| 国产精品久久久久9999爆乳| 国产激情综合五月久久| 久99视频精品免费观看福利| 国语自产精品视频在线第100页 | 免费又黄又爽又色的视频| 国产一区二区精品久久| 久久国内精品自在自线观看| 亚洲乱色熟女一区二区三区丝袜| 人妻少妇中文字幕久久| 妓院一钑片免看黄大片| 午夜福利视频合集1000 | 青青青国产在线观看资源| 成人做受120秒试看试看视频| 亚洲风情亚aⅴ在线发布 | 亚洲在av人极品无码| 亚洲 综合 自拍 精品 在线| 国产精品丰臀| 亚洲妇熟xxxx妇色黄| 国产福利姬喷水福利在线观看| 国产啪精品视频网站免费尤物| 里番本子纯肉侵犯肉全彩无码| 精品爆乳一区二区三区无码av| 黑人强伦姧人妻久久| 精品人妻无码一区二区三区蜜桃一 | 国产高清视频色拍| 欧美日本免费一区二区三区| 波多野结衣在线播放| 亚洲高清成人aⅴ片| 久久精品女同亚洲女同| 国产精品欧美亚洲韩国日本久久| 亚洲人成无码www久久久| 亚洲精品卡一卡三卡四卡乱码| 国产无套精品一区二区| 欧美破苞系列二十三| 中文亚洲无线码49vv| 国产一区二区三区精品视频|