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  4. PHOX2A Antibody, Biotin conjugated

PHOX2A Antibody, Biotin conjugated

  • 中文名稱：
    PHOX2A兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA017940LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PHOX2A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PHOX2A
  • 別名：
    Aristaless homeobox (Drosophila) fibrosis of extraocular muscles congenital 2 autosomal recessive antibody; Aristaless homeobox gene homolog (Drosophila) antibody; Aristaless homeobox homolog antibody; Aristaless homeobox protein homolog antibody; ARIX 1 homeodomain protein antibody; ARIX antibody; Arix homeodomain protein antibody; ARIX1 homeodomain protein antibody; CFEOM 2 antibody; CFEOM2 antibody; FEOM 2 antibody; FEOM2 antibody; Fibrosis of extraocular muscles congenital 2 autosomal recessive antibody; MGC52227 antibody; NCAM 2 antibody; NCAM2 antibody; Paired like (aristaless) Homeobox 2A antibody; Paired like homeobox 2a antibody; Paired mesoderm homeobox 2a antibody; Paired mesoderm homeobox protein 2A antibody; Paired-like homeobox 2A antibody; PHOX 2A antibody; Phox2 antibody; Phox2a antibody; PHX2A_HUMAN antibody; Pmx 2a antibody; Pmx2 antibody; Pmx2a antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Paired mesoderm homeobox protein 2A protein (150-264AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
  • 基因功能參考文獻(xiàn)：
    1. PHOX2A expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B down-regulation. PMID: 26902400
    2. Genetic linkage was found at 11q13 between D11S4151 and D11S1320 and the PHOX2A gene. PMID: 22311481
    3. Patients with ARIX and/or PHOX2B polymorphisms had less hypoplastic superior oblique muscles. PMID: 22170461
    4. Mutations in the human ortholog of Aristaless cause X-linked mental retardation and epilepsy PMID: 11889467
    5. The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status PMID: 11943777
    6. PHOX2A mutation analysis revealed a novel nonsense mutation in CFEOM2 (congenital fibrosis of extraocular muscles type 2) PMID: 14597037
    7. the polymorphisms of the ARIX gene and PHOX2B gene may be genetic risk factors for the development of congenital superior oblique muscle palsy PMID: 16049556
    8. PHOX2A, but not PHOX2B, seems to act directly on the c-RET promoter PMID: 16127999
    9. Together, these results suggest that phosphorylation of Arix by ERK1/2 inhibits its ability to interact with target genes, and that both specificity of expression and modulation by external stimuli are monitored through the same transcription factor. PMID: 16156742
    10. These results demonstrate the direct interactions of the Phox2a and b and dHAND transcription factors within a noradrenergic cell type PMID: 16280598
    11. the alpha3 subunit is expressed in every terminally differentiated ganglionic cell, this is the first example of a "pan-autonomic" gene whose expression is regulated by PHOX2 proteins. PMID: 17344216
    12. PHOX2A, like PHOX2B, is involved in the cascade leading to transcription factor TLX2 transactivation and presumably is involved in intestinal neuronal differentiation. PMID: 17505528
    13. a variant of Secretogranin II has a role in regulation by PHOX2 transcription factors and in hypertension PMID: 17584765
    14. The ARIX 153G>A polymorphism might be a genetic risk factor for the development of congenital superior oblique muscle palsy PMID: 18323871
    15. PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma. PMID: 18949361
    16. PHOX2A gene, localized in a tumor suppressor candidate region at 11q, weas screened for mutations by DNA sequencing in 47 tumors of different stages. PMID: 19212675
    17. Transfection of Phox2a cDNA significantly increases mRNA and protein levels of norepinephrine transporter and dopamine beta-hydroxylase. PMID: 19573018
    18. Our 16-patient sample suggests that KIF21A and PHOX2A sequence variation does not have a role in common forms of congenital incomitant vertical strabismus. PMID: 19852579

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  • 相關(guān)疾病：
    Fibrosis of extraocular muscles, congenital, 2 (CFEOM2)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 691

    OMIM: 602078

    KEGG: hsa:401

    STRING: 9606.ENSP00000298231

    UniGene: Hs.731115



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