在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PHLDA1 Antibody

  • 中文名稱:
    PHLDA1兔多克隆抗體
  • 貨號:
    CSB-PA941299
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from RAW264.7 cells, using PHLA1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PHLDA1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PHLDA1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human PHLA1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.
  • 基因功能參考文獻:
    1. suggest a unique regulatory feature of PHLDA1 to inhibit the ErbB receptor oligomerization process and thereby control the activity of receptor signaling network. PMID: 29233889
    2. Data identified PHLDA1 as a novel p53 target with an ability to repress Akt. PHLDA1 has a so-called split PH domain divided into an N-terminal and a C-terminal portions and seems to be responsible for its localization to the plasma membrane and binding to phosphatidylinositol. In addition, PHLDA1 expression analysis suggests that PHLDA1 has a tumor suppressive function in breast and ovarian cancers. PMID: 30207029
    3. Our study negatively correlates expression of PHLDA1 and Aurora A in IMR-32 cells and sheds new light on functions of PHLDA1 in the neuroblastoma tumor cells, suggesting its role as a pro-apoptotic protein PMID: 27278006
    4. Suggest decreased expression of PHLDA1 may play an important role in tumor progression, and may become a new adjunct biomarker in the prognosis in gastric adenocarcinoma. PMID: 26191222
    5. Data suggest that high PHLDA1 expression is controlled through an ER-NFkappaB-miR-181 regulatory axis and may contribute to a poor clinical outcome in patients with ER+ breast tumors by enhancing stem-like properties in these tumors. PMID: 24954507
    6. PHLDA1 expression is a useful addition in differentiating trichoblastoma and basal cell carcinoma. PMID: 23719479
    7. A role for PHLDA1 as an apoptosis suppressor in oral cancer cells. PMID: 24270013
    8. Data show that downregulation of aurora A kinase by the therapeutic antibody is associated with decreased levels of MYCN protein in cytoplasm, and induced expression of PHLDA1 and P53 proteins. PMID: 23962557
    9. The follicular stem cell marker PHLDA1 (TDAG51) indicates that most basaloid tumors in nevus sebaceus are basal cell carcinomas and not trichoblastomas. PMID: 23489134
    10. PHLDA1 differentiates between desmoplastic trichoepithelioma and morpheaform basal cell carcinoma but shows variable staining in microcystic adnexal carcinoma. PMID: 23398472
    11. the release of Ca(2+) from endoplasmic reticulum stores mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium via the induction of TDAG51 PMID: 22592641
    12. crucial negative regulator and effector of Aurora A kinase in breast cancer PMID: 21807936
    13. PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis PMID: 21558389
    14. The progressive loss of PHLDA1 expression in melanomas may play a role in deregulated cell growth and apoptosis resistance in these tumors. PMID: 12384558
    15. expression of TDAG51 in human T-cells does not correlate with activation-induced cell death PMID: 15002043
    16. TDAG51 plays an important role in the anti-apoptotic effects of IGF-I. PMID: 15037619
    17. TDAG51 locus shows an operon-like organization of two head-to-head oriented transcripts that are inversely regulated in T lymphocytes by a CpG-rich bidirectional promoter. PMID: 15315823
    18. Reduced PHLDA1 expression is important in breast cancer progression and could serve as useful prognostic marker of disease outcome. PMID: 17211533
    19. TDAG51 in patients with intractable epilepsy was significantly higher when compared with levels in the controls. PMID: 17870236
    20. The anti-estrogen ICI 182,780 (1 microM) inhibited PHLDA1 mRNA expression and completely abolished the effect of 10 nM 17beta-estradiol on PHLDA1 expression (P < 0.05), suggesting that PHLDA1 is regulated by estrogen via ER. PMID: 18641796

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasmic vesicle. Nucleus, nucleolus.
  • 組織特異性:
    Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level).
  • 數據庫鏈接:

    HGNC: 8933

    OMIM: 605335

    KEGG: hsa:22822

    STRING: 9606.ENSP00000266671

    UniGene: Hs.602085



主站蜘蛛池模板: 国产蜜臀av在线一区尤物| 亚洲国产精品成人天堂| 国产亚洲精品a在线观看下载| 欧洲日本一线二线三线区本庄铃| 中文字幕无码不卡一区二区三区| 少妇无码一区二区三区免费| 国产成人片无码免费视频软件| 精品无码av一区二区三区| 情侣黄网站免费看| 又色又爽又黄的视频日本| 亚洲欧美综合成人五月天网站| 东北少妇不戴套对白第一次| 亚洲精品天堂成人片av在线播放| 亚洲欧洲日产国码无码| 久久www成人免费网站| 亚洲日韩国产一区二区三区| 成人区人妻精品一熟女| 国产精品厕所| 巨大乳女人做爰视频在线看| www国产亚洲精品久久| 国产精品视频白浆免费视频| 国产精品无码专区| 樱花草在线社区www中国| 玩弄丰满熟妇xxxxx性60| 国产影片av级毛片特别刺激| 亚洲精品成人无限看| 国产成年无码久久久久下载| 中文字幕 亚洲精品 第1页| 亚洲国产中文曰韩丝袜| 欧美肥胖老太vidio在线视频| 爆乳熟妇一区二区三区| 国产成人午夜高潮毛片| av鲁丝一区鲁丝二区鲁丝三区| 亚洲妇女自偷自偷图片| 天堂在线www资源在线| 精品国精品自拍自在线| 50岁退休熟女露脸高潮| 国产精品一线二线三线| 国产精品人人妻人人爽人人牛| 欧美xxxx做受视频| 成人亚洲精品777777|