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  4. PHIP Antibody, Biotin conjugated

PHIP Antibody, Biotin conjugated

  • 中文名稱：
    PHIP兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA837866LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PHIP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PHIP
  • 別名：
    PHIP antibody; DCAF14 antibody; WDR11 antibody; PH-interacting protein antibody; PHIP antibody; DDB1- and CUL4-associated factor 14 antibody; IRS-1 PH domain-binding protein antibody; WD repeat-containing protein 11 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PH-interacting protein (508-608AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
  • 基因功能參考文獻：
    1. The replication initiation determinant protein PHIP modulates replication by recruiting CUL4 to chromatin. PMID: 30018425
    2. These results provide further support for PHIP as a molecular prognostic marker of melanoma, and reveal a significant linkage between PHIP levels and ulceration. PMID: 24005052
    3. The PHIP gene resides on 6q14.1, and although 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and patient samples, and its overexpression was an independent adverse predictor of survival in melanoma patients. PMID: 22511720
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in myeloma and epidermoid carcinoma cell lines.
  • 數據庫鏈接：

    HGNC: 15673

    OMIM: 612870

    KEGG: hsa:55023

    STRING: 9606.ENSP00000275034

    UniGene: Hs.511817



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