在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. PHF19 Antibody

PHF19 Antibody

  • 中文名稱：
    PHF19兔多克隆抗體
  • 貨號：
    CSB-PA017907GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PHF19
  • 別名：
    PHF19 antibody; PCL3 antibody; PHD finger protein 19 antibody; Polycomb-like protein 3 antibody; hPCL3 antibody
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Human PHF19
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF,IP
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
  • 基因功能參考文獻：
    1. These results provide evidence that PHF19 promotes Hepatocellular carcinoma and is regulated by the tumor-suppressor, miR-195-5p PMID: 25955388
    2. The histone H3K36me3 binding by the Tudor domains of PHF1, PHF19 and likely MTF2 provide another recruitment and regulatory mechanism for the PRC2 complex PMID: 23228662
    3. propose a model whereby PHF19 functions during mouse embryonic stem cell differentiation to transiently bind the H3K36me3 mark via its Tudor domain PMID: 23160351
    4. PHF19 silencing reduces the cell proliferation rate and increases the transendothelial migration capacities of melanoma cell lines. PMID: 22487681
    5. Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes PMID: 21143197
    6. identification of a gene encoding a human homologue of the Drosophila polycomblike protein, hPCL3 gene, encoding two nuclear proteins, hPCL3S and hPCL3L; markedly overexpressed in many types of cancers PMID: 15563832

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Polycomblike family
  • 組織特異性：
    Isoform 1 is expressed in thymus, heart, lung and kidney. Isoform 2 is predominantly expressed in placenta, skeletal muscle and kidney, whereas isoform 1 is predominantly expressed in liver and peripheral blood leukocytes. Overexpressed in many types of c
  • 數據庫鏈接：

    HGNC: 24566

    OMIM: 609740

    KEGG: hsa:26147

    STRING: 9606.ENSP00000363003

    UniGene: Hs.460124



主站蜘蛛池模板： 欧美精品无码久久久久久| 国产精品无码一区二区在线a片| 综合欧美亚洲日本一区| 亚洲第一a在线观看网站| 日本亚洲色大成网站www久久| 黄网站欧美内射| 草草久久97超级碰碰碰| 强 暴 疼 哭 处 女 身子视频| 欧美日韩亚洲国内综合网| 久久久国产精品消防器材| 无码写真精品永久福利在线| 国产成人一区二区三区免费视频| 又粗又大又黄又爽的免费视频| 精品欧洲av无码一区二区三区| 亚洲中文字幕在线第二页| 欧美人与动性行为视频| 成熟妇人a片免费看网站| 看成年女人午夜毛片免费| 一本一道中文字幕无码东京热| 亚洲一区二区三区自拍天堂| 久久久久久成人毛片免费看| 国产精品无码无卡无需播放器| 女学生14毛片视频片二毛| 浓毛欧美老妇乱子伦视频| 日本无码欧美一区精品久久| 一区二区三区波多野结衣在线观看| 日日拍夜夜嗷嗷叫|日日摸| 在线精品亚洲一区二区小说| 国产成年无码v片在线| 牛牛在线视频| 午夜精品电影你懂的| 最新亚洲一卡二卡三卡四卡| 亚洲国产精品成人久久蜜臀| 亚洲 自拍 另类小说综合图区| 久久亚洲人成电影网| 国产交换配乱婬视频| 国产麻豆成人精品av| 日韩高清成片免费视频| 九九久久精品国产| 人人妻人人爽人人做夜欢视频| 综合自拍亚洲综合图区欧美|