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PHAX Antibody

  • 中文名稱:
    PHAX兔多克隆抗體
  • 貨號:
    CSB-PA863999LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: A549 whole cell lysate
      All lanes: PHAX antibody at 2.8µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45 kDa
      Observed band size: 45 kDa
    • Immunofluorescent analysis of Hela cells using CSB-PA863999LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PHAX Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PHAX
  • 別名:
    FLJ13193 antibody; PHAX antibody; PHAX_HUMAN antibody; Phosphorylated adapter RNA export protein antibody; Phosphorylated adaptor for RNA export antibody; RNA U small nuclear RNA export adapter protein antibody; RNA U; small nuclear RNA export adapter (phosphorylation regulated) antibody; RNUXA antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Phosphorylated adapter RNA export protein (6-243AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PHAX Antibody (CSB-PA863999LA01HU),的標記方式是Non-conjugated。對于PHAX Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA863999LB01HU PHAX Antibody, HRP conjugated ELISA
    FITC CSB-PA863999LC01HU PHAX Antibody, FITC conjugated
    Biotin CSB-PA863999LD01HU PHAX Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
  • 基因功能參考文獻:
    1. PHAX RNA-binding domain mediates auxiliary RNA contracts with small nuclear and mall nucleolar RNA substrates. PMID: 20430857
    2. PHAX and CRM1 have roles in transporting U3 snoRNA to nucleoli PMID: 15574332
  • 亞細胞定位:
    Nucleus, nucleoplasm. Nucleus, Cajal body. Cytoplasm.
  • 蛋白家族:
    PHAX family
  • 數據庫鏈接:

    HGNC: 10241

    OMIM: 604924

    KEGG: hsa:51808

    STRING: 9606.ENSP00000297540

    UniGene: Hs.555731



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