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  4. PHACTR4 Antibody

PHACTR4 Antibody

  • 中文名稱：
    PHACTR4兔多克隆抗體
  • 貨號：
    CSB-PA050104
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PHACTR4
  • 別名：
    Phactr4 antibody; PHAR4_HUMAN antibody; Phosphatase and actin regulator 4 antibody; PRO2963 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PHACTR4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway.
  • 基因功能參考文獻(xiàn)：
    1. Data indicate that Phactr4 acts as a tumor suppressor that is deleted and mutant in several cancers. PMID: 23319639
    2. The authors show that rat Phactr1 inhibits PP1 activity in vitro, and mouse Phactr4 coimmunoprecipitates with actin and PP1 in human cells. PMID: 15107502
  • 亞細(xì)胞定位：
    Cytoplasm. Cell projection, lamellipodium.
  • 蛋白家族：
    Phosphatase and actin regulator family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25793

    OMIM: 608726

    KEGG: hsa:65979

    UniGene: Hs.225641



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