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PFKFB2 Antibody, FITC conjugated

  • 中文名稱:
    PFKFB2兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA017818LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) PFKFB2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    6 phosphofructo 2 kinase/fructose 2 6 biphosphatase 2 antibody; 6-bisphosphatase antibody; 6-P2ase 2 antibody; 6-P2ASE heart-type isozyme antibody; 6PF 2 K/Fru 2 6 P2ASE heart type isozyme antibody; 6PF-2-K/Fru-2 antibody; 6PF-2-K/Fru-26-P2ase 2 antibody; 6PF-2-K/Fru-26-P2ase heart-type isozyme antibody; F262_HUMAN antibody; Fructose 2 6 bisphosphatase cardiac isozyme antibody; Fructose-2 antibody; PFK 2/FBPase 2 antibody; PFK/FBPase 2 antibody; PFKFB cardiac antibody; PFKFB2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 protein (360-505AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Synthesis and degradation of fructose 2,6-bisphosphate.
  • 基因功能參考文獻(xiàn):
    1. UCA1/miR-182/PFKFB2 axis modulates chemokine CXCL14 secretion, glycolysis and invasion of glioma cells in glioblastoma-associated stromal cells . PMID: 29655792
    2. Crystal structure of human and cattle heart PFKFB2 and the inhibitory influence of citrate on substrate binding has been described. PMID: 27802586
    3. Variation in PFKFB2 appears to reduce PFKFB2 expression in adipose and kidney tissues, and thereby increase risk for adiposity and diabetic nephropathy. PMID: 25662186
    4. Highly expressed PFKFB2 protein is associated with hepatocellular carcinoma. PMID: 24568531
    5. bifunctionality of PFK-2/FBPase-2 complements the metabolic zonation of the liver by ensuring coherent switching in response to insulin and glucagon. PMID: 24634222
    6. amino acids stimulate Fru-2,6-P2 synthesis by Akt-dependent PFKFB2 phosphorylation and activation and show how signaling and metabolism are inextricably linked. PMID: 23457334
    7. A persistent increase in 6-phosphofructo-2-kinase produced by a change in PFK-2/FBPase-2 isoform expression that may play an important role in the regulation of muscle glycolysis. PMID: 22241065
    8. Suggest that PFKFB2 is not an essential upstream regulator of the anti-leukemic effects of glucocorticoids. PMID: 21092265
    9. induction of de novo lipid synthesis by androgen requires transcriptional up-regulation of HK2 and PFKFB2, and phosphorylation of PFKFB2 generated by the PI3K/Akt signal pathway to supply the source for lipogenesis from glucose in prostate cancer cells. PMID: 20958264
    10. Human islets expressed the PFKFB2 and PFKFB3 isoforms. PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced insulin secretion through regulation of glucokinase activity PMID: 18039179

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  • 蛋白家族:
    Phosphoglycerate mutase family
  • 組織特異性:
    Heart.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 8873

    OMIM: 171835

    KEGG: hsa:5208

    STRING: 9606.ENSP00000356047

    UniGene: Hs.282702



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