在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PEX5 Antibody

  • 中文名稱:
    PEX5兔多克隆抗體
  • 貨號:
    CSB-PA017805LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate
      All lanes: PEX5 antibody at 7.4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 71, 67, 70, 73 kDa
      Observed band size: 71 kDa
    • IHC image of CSB-PA017805LA01HU diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PEX5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    PEX5
  • 別名:
    FLJ50634 antibody; FLJ50721 antibody; FLJ51948 antibody; PBD2A antibody; PBD2B antibody; Peroxin 5 antibody; Peroxin-5 antibody; Peroxisomal biogenesis factor 5 antibody; Peroxisomal C terminal targeting signal import receptor antibody; Peroxisomal C-terminal targeting signal import receptor antibody; Peroxisomal targeting signal 1 (SKL type) receptor antibody; Peroxisomal targeting signal 1 receptor antibody; Peroxisomal targeting signal import receptor antibody; Peroxisomal targeting signal receptor 1 antibody; Peroxisome receptor 1 antibody; pex5 antibody; PEX5_HUMAN antibody; PTS1 BP antibody; PTS1 receptor antibody; PTS1-BP antibody; PTS1R antibody; PXR1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Peroxisomal targeting signal 1 receptor protein (149-283AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,PEX5 Antibody (CSB-PA017805LA01HU),的標記方式是Non-conjugated。對于PEX5 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA017805LB01HU PEX5 Antibody, HRP conjugated ELISA
    FITC CSB-PA017805LC01HU PEX5 Antibody, FITC conjugated
    Biotin CSB-PA017805LD01HU PEX5 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.
  • 基因功能參考文獻:
    1. these findings lend credit to the idea that inefficient catalase import, when coupled with the role of PEX5 as a redox-regulated import receptor, constitutes a cellular defense mechanism to combat oxidative insults of extra-peroxisomal origin. PMID: 28760655
    2. TRIM37-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal matrix protein import, suggesting that mulibrey nanism is a new peroxisomal biogenesis disorder. PMID: 28724525
    3. Data suggest that soluble/cytosolic PEX5 interacts with PEX14/PEX13 complex, a model for the docking/translocation module (DTM) of the peroxisomal matrix protein translocon; PEX14/PEX13 complex appears to function in peroxisomal membrane as large cavity into which cytosolic PEX5 can enter to release its cargo. (PEX = peroxisomal biogenesis factor) PMID: 28765278
    4. data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 and PEX5 or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes. PMID: 27311714
    5. our data suggest that insertion of the trimeric PEX5-PEX7-PTS2 protein complex into the DTM is probably accompanied by conformational alterations in PEX5 to allow release of the PTS2 protein into the organelle matrix PMID: 26138649
    6. Our data suggest that the functional polymorphism rs3814058C>T in 3'-UTR of PXR may be a functional biomarker to predict risk of colorectal cancer PMID: 26547791
    7. PEX5 encodes two isoforms, PEX5L & PEX5S, & a homozygous frame shift mutation c.722dupA (p.Val242Glyfs( *)33), located in the PEX5L-specific exon 9, results in loss of PEX5L only. Loss of PEX5L results in deficient import of PTS2-tagged proteins PMID: 26220973
    8. bulky side chain within the recognition motif, which blocks contraction of the PEX5 binding cavity PMID: 25369882
    9. Data show that ataxia-telangiectasia mutated (ATM) phosphorylates peroxisomal biogenesis factor 5 (PEX5) at serine 141 in response to reactive oxygen species. PMID: 26344566
    10. the molecular recognition of PTS1 cargo proteins by Pex5p PMID: 25689234
    11. ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulating PTS1 protein import PMID: 24662292
    12. PEX5 has a role in regulating peroxisome numbers by signaling to mediate pexophagy PMID: 24453954
    13. Cys11 in PEX5 serves as a functional redox switch regulating the peroxisomal/cytosolic localization of peroxisomal proteins. PMID: 24118911
    14. The novel Pex14-binding site may represent the initial tethering site of Pex5 from which the cargo-loaded receptor is further processed in a sequential manner. PMID: 24235149
    15. Translocation of proteins across the organelle membrane occurs downstream of a reversible docking step and upstream of the first cytosolic ATP-dependent step, i.e. before ubiquitination of PEX5. PMID: 23963456
    16. The molecular mechanism of recognition by the peroxisomal receptor Pex5p, in complex with alanine-glyoxylate aminotransferase revealed by X-ray crystallography. PMID: 22529745
    17. Our results suggest that ubiquitin-specific protease 9X (USP9X) is by far the most active deubiquitinase acting on Ub-PEX5, both in female rat liver and HeLa cells. PMID: 22371489
    18. interaction of PEX5 with catalase and PEX14 PMID: 21976670
    19. The Peroxisomal targeting signal 1 in Scp2 is autonomous and is essential for binding to pex5. PMID: 21375735
    20. the affinities of the PTS1-containing peptides from 42 proteins from the human proteome for Pex5p PMID: 20178365
    21. Data suggest that translocation of PTS1-containing proteins across the peroxisomal membrane occurs concomitantly with formation of the Pex5p-Pex14p membrane complex and that this is probably the site from which Pex5p leaves the peroxisomal compartment. PMID: 12411433
    22. binds the PTS1 independently of Hsp70 and the peroxin PEX12 PMID: 12456682
    23. Binding energy threshold data have been generated for PTS1 pentapeptides containing different C-terminal tripeptide sequences to determine the functionality of specific PTS1 sequences. PMID: 12578380
    24. concluded that the PTS1 domain of SR-BI is functional and can mediate peroxisomal interaction via Pex5p, in vitro PMID: 14652019
    25. the N terminus of Pex5p is required for redirecting the peroxisome-associated peroxin back to the cytosol PMID: 15328363
    26. Pex5p is a monomeric protein with an abnormal shape PMID: 15866874
    27. Pex5 most likely enters peroxisomes, changes its interacting partners, and then exits using ATP energy. PMID: 16314507
    28. Results indicate that the N-terminal half of Pex5p is best described as a natively unfolded pre-molten globule-like domain. PMID: 16403517
    29. study shows mutation-dependent, gain-of-function association between myocilin & PTS1R; there was correlation between glaucoma phenotype & specific MYOC mutations, with more severe early-onset POAG mutations having higher degree of association with PTS1R PMID: 17317787
    30. Results describe the affinities of mutated forms of Pex5p for a series of peroxisomal targeting signal type-1 (PTS1) peptides and conclude that PTS1-affinity reductions are correlated with Zellweger disease severity and cell biological phenotype. PMID: 17399738
    31. A previously unobserved conformation for PEX5 suggests roles for intrinsic flexibility and rigid domain motions in ligand binding. PMID: 17428317
    32. E2D1/2/3 (UbcH5a/b/c) are the mammalian functional counterparts of yeast/plant Pex4p PMID: 18359941
    33. The location of the different mutations within the PEX5 amino acid sequence correlates rather well with the peroxisomal protein import defect observed in the cell lines. PMID: 18712838
    34. Results describe the properties of the soluble and membrane-bound monoubiquitinated Pex5p species (Ub-Pex5p). PMID: 19208625
    35. analysis of the human Pex5.Pex14.PTS1 protein complex structure obtained by small angle X-ray scattering PMID: 19584060
    36. the step of protein translocation across the peroxisomal membrane into the PEX5 cycling pathway PMID: 19632994

    顯示更多

    收起更多

  • 相關疾病:
    Peroxisome biogenesis disorder 2A (PBD2A); Peroxisome biogenesis disorder 2B (PBD2B); Rhizomelic chondrodysplasia punctata 5 (RCDP5)
  • 亞細胞定位:
    Cytoplasm. Peroxisome membrane; Peripheral membrane protein. Note=Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).
  • 蛋白家族:
    Peroxisomal targeting signal receptor family
  • 組織特異性:
    Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 9719

    OMIM: 202370

    KEGG: hsa:5830

    STRING: 9606.ENSP00000407401

    UniGene: Hs.567327



主站蜘蛛池模板: 欲求不满邻居的爆乳在线播放| 中文字幕av无码一区二区三区 | 精品国产污污免费网站入口| 亚洲色成人网站www永久四虎 | 婷婷色婷婷开心五月四房播播久久| 三级全黄的视频在线观看| 午夜福利三级理论电影| 国产又色又爽又黄的| 国产一区二区三区在线蜜桃| av无码av无码专区| 欲妇荡岳丰满少妇岳| 青青草视频在线观看| 国产免国产免‘费| 久久亚洲精品无码爱剪辑| h人成在线看免费视频| 日本一区二区三区免费高清| 国产成人无码18禁午夜福利p| 醉酒后少妇被疯狂内射视频| av网站的免费观看| 色妺妺视频网| 久久久久久人妻一区二区三区| 欧美人牲口杂交在线播放免费| 亚洲国产av无码综合原创国产| 久久精品无码一区二区三区免费| 97人妻人人揉人人躁人人| 性色欲情网站| 天天影视性色香欲综合网| 朝鲜女人大白屁股ass孕交| 一区二区三区国产亚洲网站| 97在线成人国产在线视频| 欧美va久久久噜噜噜久久| 久久午夜无码鲁丝片午夜精品| 人人鲁人人莫人人爱精品| 亚洲精品无码乱码成人| 内射老阿姨1区2区3区4区| 99精品久久99久久久久| 黄网站成人片免费视频| 亚洲午夜福利院在线观看| 搡8o老女人老妇人老熟| 免费无码av片在线观看潮喷| 精品国产乱码久久久软件下载|