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  4. PEX26 Antibody, FITC conjugated

PEX26 Antibody, FITC conjugated

  • 中文名稱：
    PEX26兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA767196LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PEX26 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PEX26
  • 別名：
    PEX26 antibody; Peroxisome assembly protein 26 antibody; Peroxin-26 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Peroxisome assembly protein 26 protein (1-159AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence.
  • 基因功能參考文獻(xiàn)：
    1. In yeast, PEX26 follows the pathway that also ensures correct targeting of Pex15: PEX26 enters the endoplasmic reticulum (ER) in a GET-dependent and Pex19-independent manner. PMID: 26627908
    2. results suggested that peroxisome biogenesis requires Pex1p- and Pex6p-regulated dissociation of Pex14p from Pex26p PMID: 25016021
    3. PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway. PMID: 23460677
    4. degree of temperature sensitivity in pex26 cell lines is predictive of the clinical phenotype in patients with PEX26 deficiency PMID: 12851857
    5. PEX26 deficiency impairs peroxisomal import of both PTS1- and PTS2-targeted matrix proteins. It undergoes alternative splicing to produce several splice forms, including PEX26-delta, which rescues peroxisome biogenesis in PEX26-deficient cells. PMID: 15858711
    6. Pex26p functions in recruiting to peroxisomes the complexes of the AAA ATPase peroxins. PMID: 16257970
    7. We analyzed targeting of human PEX26. Its C-terminal-targeting signal contains two binding sites for PEX19 and we conclude C-terminal PEX19-binding sites mark tail-anchored proteins for delivery to peroxisomes. PMID: 16763195
    8. the relative fraction of disease-causing alleles that occur in the coding and splice junction sequences of PEX26 gene. PMID: 19105186

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  • 相關(guān)疾病：
    Peroxisome biogenesis disorder complementation group 8 (PBD-CG8); Peroxisome biogenesis disorder 7A (PBD7A); Peroxisome biogenesis disorder 7B (PBD7B)
  • 亞細(xì)胞定位：
    Peroxisome membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peroxin-26 family
  • 組織特異性：
    Widely expressed. Highly expressed in kidney, liver, brain and skeletal muscles. Expressed at intermediate level in pancreas, placenta and heart. Weakly expressed in lung.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 22965

    OMIM: 608666

    KEGG: hsa:55670

    STRING: 9606.ENSP00000331106

    UniGene: Hs.517400



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