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  4. PEX13 Antibody, HRP conjugated

PEX13 Antibody, HRP conjugated

  • 中文名稱：
    PEX13兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA849799LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PEX13 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PEX13
  • 別名：
    2610008O20Rik antibody; NALD antibody; OTTMUSP00000005454 antibody; Peroxin 13 antibody; Peroxin-13 antibody; Peroxin13 antibody; Peroxisomal membrane protein PEX 13 antibody; Peroxisomal membrane protein PEX13 antibody; Peroxisome biogenesis factor 13 antibody; PEX 13 antibody; pex13 antibody; PEX13_HUMAN antibody; RP23-188K3.1 antibody; ZWS antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Peroxisomal membrane protein PEX13 protein (1-130AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins.
  • 基因功能參考文獻：
    1. Data suggest that soluble/cytosolic PEX5 interacts with PEX14/PEX13 complex, a model for the docking/translocation module (DTM) of the peroxisomal matrix protein translocon; PEX14/PEX13 complex appears to function in peroxisomal membrane as large cavity into which cytosolic PEX5 can enter to release its cargo. (PEX = peroxisomal biogenesis factor) PMID: 28765278
    2. our results demonstrate that PEX13 is required for selective autophagy, and suggest that dysregulation of PEX13-mediated mitophagy may contribute to ZSS pathogenesis. PMID: 27827795
    3. Results show PEX13 interacts with itself in peroxisomes in living cells and the import of PTS1 (peroxisomal targeting signal 1) proteins is specifically disrupted when homooligomerization of PEX13 is interrupted. PMID: 23716570
    4. Pex13p has a role in determining the peroxisomal localization of Pex14p PMID: 14715663
    5. analysis of PEX13 substitution of Ile326 by threonine in a patient with peroxisomal biogenesis disorder [case report] PMID: 16006427
    6. Zellweger syndrome caused by PEX13 deficiency: report of two novel mutations. PMID: 19449432

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  • 相關疾病：
    Peroxisome biogenesis disorder complementation group 13 (PBD-CG13); Peroxisome biogenesis disorder 11A (PBD11A); Peroxisome biogenesis disorder 11B (PBD11B)
  • 亞細胞定位：
    Peroxisome membrane; Single-pass membrane protein.
  • 蛋白家族：
    Peroxin-13 family
  • 數據庫鏈接：

    HGNC: 8855

    OMIM: 601789

    KEGG: hsa:5194

    STRING: 9606.ENSP00000295030

    UniGene: Hs.161377



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