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PEX11B Antibody

  • 中文名稱:
    PEX11B兔多克隆抗體
  • 貨號:
    CSB-PA003740
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of Jurkat cells using Peroxin 11β Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    PEX11B
  • 別名:
    PEX11B; Peroxisomal membrane protein 11B; Peroxin-11B; Peroxisomal biogenesis factor 11B; Protein PEX11 homolog beta; PEX11-beta
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat,Monkey
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Peroxin 11β.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface.
  • 基因功能參考文獻:
    1. Next generation sequencing identified biallelic loss-of-function mutations in PEX11B as the underlying cause of disease in each case (PEX11B c.235C>T p.(Arg79Ter) homozygous; PEX11B c.136C>T p.(Arg46Ter) homozygous; PEX11B c.595C>T p.(Arg199Ter) heterozygous, PEX11B ex1-3 del heterozygous). PMID: 28129423
    2. Self-interaction of human Pex11beta during peroxisomal growth and division regulates its membrane deforming activity in conjunction with membrane lipids. PMID: 23308220
    3. Excluding mutations in all PEX genes previously implicated in peroxisome biogenesis disorders, it was found that the defect was caused by a homozygous non-sense mutation in the PEX11beta gene. PMID: 22581968
    4. A new study identifies the first patient with a mutation in PEX11beta.These new findings widen the spectrum of clinical and cellular phenotypes of peroxisome biogenesis disorders. PMID: 22581969
    5. coordinates peroxisome membrane proliferation and maintenance PMID: 20826455
    6. Fis1 plays important roles in peroxisome division and maintenance of peroxisome morphology in mammalian cells, possibly in a concerted manner with Pex11pbeta and DLP1. PMID: 17408615

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  • 相關疾病:
    Peroxisome biogenesis disorder 14B (PBD14B)
  • 亞細胞定位:
    Peroxisome membrane; Single-pass membrane protein.
  • 蛋白家族:
    Peroxin-11 family
  • 數據庫鏈接:

    HGNC: 8853

    OMIM: 603867

    KEGG: hsa:8799

    STRING: 9606.ENSP00000358312

    UniGene: Hs.714608



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